Biodistributions of radioactive bipositive metal ions in tumor-bearing animals

Ando, Atsushi; Ando, Itsuko

doi:10.1007/bf00140490

Cited by 11 publications

(7 citation statements)

References 14 publications

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“…Studies of the distribution of palladium compounds in the tissues of rats, rabbits and dogs after intravenous or intratracheal administration indicated the highest percentage of retention in the kidneys and liver (8-21% of applied dosage), lymphatic nodes, adrenal glands, lungs and bones (37)(38)(39)(40). Also, the retention period in some of the organs was up to 104 days long (37,38).…”

Section: Discussionmentioning

confidence: 99%

Cardiotoxicity of Palladium Compounds / Kardiotoksičnost Jedinjenja Paladijuma

Peric¹,

Janković²

2013

Journal of Medical Biochemistry

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SummaryPrevious studies have shown that palladium has toxic effects on the kidney and liver, leads to deterioration of the general condition of animals, and could cause allergy in animals and humans. Considering the limited data about the influence of palladium on the cardiovascular system, the aim of our study was to evaluate the effects of palladium on the heart from available published data, and to compare the toxicity of inorganic and organic palladium compounds. Relevant studies for our review were identified from PubMed and Scopus databases. The search terms included »palladium «, »palladium compound«, »cardiotoxicity«, »toxicity«, »heart«, »myocardium«, »oxidative stress« and »myocardial enzyme«, as well as combinations of these terms. There were only two published studies with the primary purpose to investigate the effect of palladium on the cardiovascular system, while others registered the side-effects of palladium compounds on the heart. Palladium could cause arrhythmias, a drop in blood pressure, decrease of the heart rate, as well as death of experimental animals. Based on the presented data it seems that palladium does not express significant cardiac toxicity when it is bound in an organic compound. Further investigation of the effects of palladium on the heart is necessary for a clear picture of the nature and extent of its cardiac toxicity.

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Section: Discussionmentioning

confidence: 99%

Cardiotoxicity of Palladium Compounds / Kardiotoksičnost Jedinjenja Paladijuma

Peric¹,

Janković²

2013

Journal of Medical Biochemistry

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“…The distribution of 46 Sc in tumor and liver tissues has been shown to be fairly similar to that of 67 Ga [6,7]. 46 Sc is also highly concentrated in inflammatory tissues as shown for 67 Ga while the binding sites are different for the two radioisotopes both in oncologic and inflammatory targets [8].…”

Section: Introductionmentioning

confidence: 91%

Development of a radioscandium immunoconjugate for radioimmunotherapy

Moghaddam-Banaem

Jalilian²,

Pourjavid

et al. 2011

Radiochimica Acta

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Developing monoclonal antibodies labeled with beta-emitters has led to the introduction of important agents in radioimmunotherapy. In this work, Sc-46 chloride was obtained by thermal neutron activation flux of natural metallic scandium sample followed by dissolution in acidic media (radionuclidic purity via beta and gamma ray spectroscopy, 99.9% ; radiochemical purity via ITLC, > 99%) and used in radiolabeling of rituximab after conjugation with DOTA-NHS-ester. The specific activity was however not high. The conjugates were purified by molecular filtration and used in the radiolabeling. The radiochemical purity (ITLC), stability studies (ITLC and size exclusion chromatography), determination of average number of DOTA conjugated per mAb (chelate : antibody ratio, 5.8 : 1) and gel electrophoresis of [ 46 Sc]Sc-DOTA-anti-CD20 were determined followed by biodistribution studies for 46 Sc and [ 46 Sc]Sc-DOTA-anti-CD20 in wild type rats up to 72 h. The binding of the radiolabeled antibody was showed to be 60% on Raji cells. The final compound was stable in presence of PBS at 37 • C and room temperature. The accumulation of the radiolabeled antibody in liver, spleen, kidney, heart and other tissues demonstrates a pattern similar to the other radiolabeled anti-CD20 immunoconjugates. The present study shows the possibility of antibody labeling for future use in radioimmunotherapy by 47 Sc.

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“…These nuclides accumulated in viable tumor tissue, and were not seen in the necrotic tumor tissue. 17 …”

Section: Biodistribution In Tumor Tissuementioning

confidence: 99%

“…We summarized the biodistribution of 54 elements and 66 compounds in tumor bearing animals as already reported.5.6 On the other hand, we have been investigating the biodistribution of radioactive metal nuclides in tumor tissue by macroautoradiography. 7,8,[13][14][15][16][17] In this study, metal organic compounds such as 67 Gacitrate and 95Zr-oxalate, were classified as inorganic compounds because these metal nuclides were dissociated from these metal organic compounds in the body after intravenous (IV) or intraperitoneal (IP) administration. To date we have investigated the biodistributions of 17 elements in tumor tissue and examined the relationship between the accumulation in tumor tissue and the properties of these metal compounds.…”

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confidence: 99%

Relationship between the biodistributions of radioactive metal nuclides in tumor tissue and the physicochemical properties of these metal ions

Ando

Sanada

et al. 1999

Ann Nucl Med

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This study was undertaken to elucidate the relationship between the biodistribution of radioactive metal nuclides in tumor tissue and its physicochemical properties. Potassium analogs (86Rb, 134Cs, 201Tl) were taken up into viable tumor tissue, although 22Na concentrated in necrotic tumor tissue. 67Ga and 111In were more predominant in inflammatory tissue than in the viable and necrotic tumor tissue. 169Yb and 167Tm accumulated in viable tumor tissue and tissue containing viable and necrotic tumor tissue. 67Ga, 111In, 169Yb and 167Tm were bound to the acid mucopolysaccharide with a mol. wt. of about 10,000 daltons in the tumor tissue. 46Sc, 51Cr, 95Zr, 181Hf, 95Nb, 182Ta, and 103Ru were highly concentrated in inflammatory tissue and were bound to the acid mucopolysaccharides with a mol. wt. exceeding 40,000 daltons. 65Zn and 103Pd concentrated in viable tumor tissue and were bound to the protein in the tissue. The results suggest that the difference in intra-tumor distribution of these elements is caused by a difference in the binding substances (or status) of these elements in the tissues, and the binding substance is determined by physicochemical properties of the elements. We therefore conclude that the biodistribution of radioactive metal ions in tumor tissue is determined by its own physicochemical properties.

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Biodistributions of radioactive bipositive metal ions in tumor-bearing animals

Cited by 11 publications

References 14 publications

Cardiotoxicity of Palladium Compounds / Kardiotoksičnost Jedinjenja Paladijuma

Cardiotoxicity of Palladium Compounds / Kardiotoksičnost Jedinjenja Paladijuma

Development of a radioscandium immunoconjugate for radioimmunotherapy

Relationship between the biodistributions of radioactive metal nuclides in tumor tissue and the physicochemical properties of these metal ions

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