2015
DOI: 10.1371/journal.pone.0138528
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Biodiversity, Anti-Trypanosomal Activity Screening, and Metabolomic Profiling of Actinomycetes Isolated from Mediterranean Sponges

Abstract: Marine sponge–associated actinomycetes are considered as promising sources for the discovery of novel biologically active compounds. In the present study, a total of 64 actinomycetes were isolated from 12 different marine sponge species that had been collected offshore the islands of Milos and Crete, Greece, eastern Mediterranean. The isolates were affiliated to 23 genera representing 8 different suborders based on nearly full length 16S rRNA gene sequencing. Four putatively novel species belonging to genera G… Show more

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Cited by 61 publications
(49 citation statements)
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“…Studies have measured the diversity and abundance of actinobacterial symbionts, finding that they are ubiquitously and stably associated within these systems (Abdelmohsen et al, 2014; Braña et al, 2015; Mahmoud and Kalendar, 2016). Subsequently, actinomycetes have been isolated from various sponges and corals to investigate their antimicrobial activities and potential to produce novel bioactive compounds (Schneemann et al, 2010; Cheng et al, 2015; Kuang et al, 2015; Pham et al, 2015; Mahmoud and Kalendar, 2016). The isolates have proved to be a rich source of NP with antifungal, antimicrobial, anti-cancer, and anti-HIV compounds (Abdelmohsen et al, 2014).…”
Section: Actinomycete Natural Products In Marine Organismsmentioning
confidence: 99%
“…Studies have measured the diversity and abundance of actinobacterial symbionts, finding that they are ubiquitously and stably associated within these systems (Abdelmohsen et al, 2014; Braña et al, 2015; Mahmoud and Kalendar, 2016). Subsequently, actinomycetes have been isolated from various sponges and corals to investigate their antimicrobial activities and potential to produce novel bioactive compounds (Schneemann et al, 2010; Cheng et al, 2015; Kuang et al, 2015; Pham et al, 2015; Mahmoud and Kalendar, 2016). The isolates have proved to be a rich source of NP with antifungal, antimicrobial, anti-cancer, and anti-HIV compounds (Abdelmohsen et al, 2014).…”
Section: Actinomycete Natural Products In Marine Organismsmentioning
confidence: 99%
“…A major shortcoming associated with such conventional investigations is the blindness of comprehensive chemical information prior to the laborious isolation work. This is frequently accompanied by the increased possibility of re‐characterisation of known compounds; making the isolation of new chemical entities to some extent an accidental or exceptional event . Likewise, bioassay‐guided isolation, which is commonly followed in natural product discovery, has been also limited by the repeated isolation of known metabolites together with the failure of purifying other trace bioactive constituents.…”
Section: Introductionmentioning
confidence: 99%
“…In the same way, phylogenetic data based on 16S rRNA gene sequence are not absolutely sufficient in microbial natural product research since related strains do not necessarily exhibit similar chemical profiles, while others belonging to different genera may unpredictably do . For this, metabolomics has growingly attracted a special interest in various aspects of natural products as a powerful and multipurpose approach, having the advantage of simultaneous analysis and characterisation of several active components in complex mixtures without detailed chromatographic work . In view of that, metabolomic profiling based on liquid chromatography mass spectrometry (LC–MS) techniques has emerged as a typical and efficient practice for exploring the chemical complexity of natural sources with limited experimental effort, which in turn allows for cost‐effective drug discovery …”
Section: Introductionmentioning
confidence: 99%
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