The study was conducted to produce the status of some wildlife species and determine the threat factors and perceptions of wildlife species in the three (3) ecological zones of Adamawa state. The study tool consists of a structured questionnaire, multi-stage and simple random sampling techniques used for data collection. Descriptive statistics with Kiringe and Okello (2007) model were used for data analysis. Results indicated that 70, 72 and 75 species of wildlife belonging to 36, 38 and 39 families were listed in the Sudan, Northern guinea and Southern guinea savannah zones, respectively. Most of the species in the three zones were either rare, endangered or have gone into local extinction. Only nine (9) species were common in the Sudan savannah zone, eleven (11) in the Northern guinea savannah zone and twenty-two (22) in the Southern guinea savannah zone. There were no abundant species in the three (3) zones. The threat factors which consistently showed the highest prevalent threat index were farming (26.0 - 45.4), hunting (32.2 – 55.4), logging (12.5 - 80) and grazing (11.2 – 17.0). The wildlife habitat susceptibility index was highest in the Sudan savannah zone (100%) but least in the Southern guinea zone (83%). Hunting (0.32 – 0.55), farming (0.26 – 0.45), logging (0.13 – 0.18) and grazing (0.12 – 0.17) consistently showed the highest mean score threat factors in the three zones. Similarly, hunting (0.00033 – 0.00010), farming (0.0023 – 0.00028), logging (0.0009 – 0.00020) and grazing (0.0009 – 0.00013) consistently showed the highest relative threat factors severity index in the three zones. Wildlife species were perceived as something good by the majority of respondents in the three (3) ecological zones. The study recommended the acquisition of skills in areas such as craft making, tailoring, shoe and bag making, motor mechanic, carpentry, mason and modern agricultural practice to prevent the local dwellers from hunting, indiscriminate expansion of agricultural land areas, illegal logging, grazing and wildfires. Policy on population control should be formulated by the government in view of increasing pressure on natural resources, which include wildlife resources. Adequate policy and institutional framework should be put in place for the purpose of management and conservation of wildlife resources at the grass root level. The state government should strengthen its conservation education programmes on the intrinsic value of wildlife to society and stiffer penalties for illegal poachers and hunters to mitigate further illegal harvesting of wildlife.