Residual herbicides and cover crops are important tools inside an integrated weed management program. The straw produced in crop rotation can interacts with herbicides. The aim of this study was to evaluate the interaction of diclosulam, sulfentrazone, imazethapyr, flumioxazin, s-metolachlor and pyroxasulfone with black oat, cereal rye, common vetch and oilseed radish cover crops and it´s reflection on weed control and soybean production. Were evaluated the biomass production of cover crops and its influence on the soybean population. A phytosociological survey of the weed community was carried out, further evaluating the control provided by the herbicides and its effects on soybean productivity. Diclosulam was the more efficient herbicide tested, reducing both weed density and biomass (68% and 89%, respectively) compared to the fallow, independently of cover crop straw. The best control levels for the population identified were provided by the combination of the herbicides diclosulam with black oat, radish or fallow. We observed that herbicide efficacy in this case was more related with control spectrum than with herbicide-straw interation. This research demonstrates that the integration of cover crops and residual herbicides is efficient in the suppression and control of weeds in the soybean crop in the no-tillage system.