Bioeffect modeling and equieffective dose concepts in radiation oncology – Terminology, quantities and units

Bentzen, Søren M.; Dörr, Wolfgang; Gahbauer, R.; Howell, Roger W.; Joiner, Michael C.; Jones, Bleddyn; Jones, D. T. L.; Kogel, Albert J. van der; Wambersie, André; Whitmore, G.F.

doi:10.1016/j.radonc.2012.10.006

Cited by 197 publications

(152 citation statements)

References 14 publications

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“…Physical doses to each voxel in the dose matrix for each treatment phase were combined to generate EQD2 -the equivalent dose in 2 Gy fractions -using an α/β of 6 Gy [2,21]. Dose bins of 0.1 Gy were used to calculate the dose received by the bladder wall surface using relative surface area of tissue receiving more than a threshold dose.…”

Section: Principal Components Of Bladder Dose-surface Histogrammentioning

confidence: 99%

Dosimetry, clinical factors and medication intake influencing urinary symptoms after prostate radiotherapy: An analysis of data from the RADAR prostate radiotherapy trial

Yahya

Ebert

Bulsara

et al. 2015

Radiotherapy and Oncology

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Urinary symptoms (frequency, incontinence, dysuria and haematuria) were prospectively assessed using LENT-SOMA to a median of 72 months. The endpoints assessed were prevalence (grade≥1) at the end of radiotherapy (representing acute symptoms), at 18-, 36-and 54-month follow-ups (representing late symptoms) and peak late incidence including only grade≥2. Impact of factors were assessed using multivariate logistic regression models with correction for over-optimism. Results: Baseline symptoms, non-insulin dependent diabetes mellitus, age and PC1 (correlated to the mean dose) impact symptoms at >1 timepoints. Associations at a single timepoint were found for cerebrovascular condition, ECOG status and non-steroidal anti-inflammatory drug intake. Peak incidence analysis shows the impact of baseline, bowel and cerebrovascular condition and smoking status. Conclusions:The prevalence and incidence analysis provide a complementary view for urinary symptom prediction. Sustained impacts across time points were found for several factors while some associations were not repeated at different time points suggesting poorer or transient impact.4

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Section: Principal Components Of Bladder Dose-surface Histogrammentioning

confidence: 99%

Dosimetry, clinical factors and medication intake influencing urinary symptoms after prostate radiotherapy: An analysis of data from the RADAR prostate radiotherapy trial

Yahya

Ebert

Bulsara

et al. 2015

Radiotherapy and Oncology

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show abstract

“…Consequently, a rigid registration is used to align the reference coordinate systems and then deformable image registration (DIR) is applied to adjust for deformations and shrinkage [9,10]. Additionally, the doses for different fraction schedules should be converted to the equieffective dose given in a reference X Gy per fraction (EQDX α/β Gy) as this adjusts for the biologically nonequivalent fractionation schedules [5,11,12].…”

Section: Introductionmentioning

confidence: 99%

Prostate external beam radiotherapy combined with high-dose-rate brachytherapy: dose-volume parameters from deformably-registered plans correlate with late gastrointestinal complications

et al. 2016

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Background: Derivation of dose-volume correlated with toxicity for multi-modal treatments can be difficult due to the perceived need for voxel-by-voxel dose accumulation. With data available for a single-institution cohort with long follow-up, an investigation was undertaken into rectal dose-volume effects for gastrointestinal toxicities after deformably-registering each phase of a combined external beam radiotherapy (EBRT)/high-dose-rate (HDR) brachytherapy prostate treatment.

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“…All dose values were converted to equieffective dose with 2 Gy absorbed dose per fraction (EQD2) 24 using the linear-quadratic model to standardize the cohort. An alpha/beta ratio of 3 Gy was used for the rectum.…”

Section: Equieffective Dosementioning

confidence: 99%

Parametrized rectal dose and associations with late toxicity in prostate cancer radiotherapy

Hamlett

McPartlin

Maile

et al. 2015

BJR

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Bioeffect modeling and equieffective dose concepts in radiation oncology – Terminology, quantities and units

Cited by 197 publications

References 14 publications

Dosimetry, clinical factors and medication intake influencing urinary symptoms after prostate radiotherapy: An analysis of data from the RADAR prostate radiotherapy trial

Dosimetry, clinical factors and medication intake influencing urinary symptoms after prostate radiotherapy: An analysis of data from the RADAR prostate radiotherapy trial

Prostate external beam radiotherapy combined with high-dose-rate brachytherapy: dose-volume parameters from deformably-registered plans correlate with late gastrointestinal complications

Parametrized rectal dose and associations with late toxicity in prostate cancer radiotherapy

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