Bioefficacy Evaluation of Commercial Mosquito Coils Containing Metofluthrin, d-Allethrin, d-Trans Allethrin, and Prallethrin Against Aedes albopictus (Diptera: Culicidae) in Malaysia

Chen, C D; Chin, A C; Low, Van Lun; Lee, H L; Lee, P K Y; Azidah, Abdul Aziz; Sofian‐Azirun, Mohd

doi:10.1093/jme/tjy130

Cited by 8 publications

(6 citation statements)

References 14 publications

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“…High frequency of household insecticide use will correlate with insecticide resistance among Culex mosquitoes (28). Resistance of mosquitoes to d-allethrin compounds is similar to the previous report from Malaysia and Indonesia that the mosquito coil containing d-allethrin 0.2% compound resulted in the low mortality rate (24, 29, 30), but different from the reports of aerosol insecticide application containing d-allethrin and d-trans allethrin from Thailand that showed mortality rate of mosquitoes were 96% (31) and 90% (32), respectively. Although distinctly different with the findings in Thailand, results of this study correspond to similar finding in Central Java Province that Cx.…”

Section: Discussionsupporting

confidence: 76%

Effect of D-Allethrin Aerosol and Coil to the Mortality of Mosquitoes

Sayono

Mudawamah

Meikawati

et al. 2019

JAD

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Background: Commercial insecticides were widely used by communities to control the mosquito population in their houses. D-allethrin is one of insecticide ingredients widely distributed in two different concentrations namely 0.15% of aerosol and 0.3% of coil formulations. We aimed to understand the mortality of indoor mosquitoes after being exposed to d-allethrin 0.15% (aerosol) and 0.3% (coil) formulations. Methods: This quasi-experiment study applied the posttest-only comparison group design. The aerosol and coil d-allethrin were used to expose the wild mosquitoes in twelve dormitory bedrooms of SMKN Jawa Tengah, a vocational high school belonging to Central Java Provincial Government, on March 2017. The compounds were exposed for 60 min to each bedroom with four-week interval for both of formulations. The knockdown mosquitoes were collected into a plastic cup and delivered to the laboratory for 24h holding, morphologically species identification and mortality recording. History of insecticide use in the dormitory was recorded by an interview with one student in each bedroom. Data were statistically analyzed with independent sample t-test and Mann-Whitney. Results: As many as 57 knockdown mosquitoes belonging to three species were obtained namely Culex fuscocephala, Cx. quinquefasciatus and Aedes aegypti with mortality rate of 50.88% after 24h holding. Knockdown and mortality of mosquitoes were significantly different based on d-allethrin formulations. D-allethrin concentrations were not effective for controlling Culex mosquitoes but effective for Ae. aegypti. Conclusion: Further efficacy of d-allethrin 0.15% aerosol to eradicate Ae. aegypti is necessary to be conducted in supporting the Dengue vector control.

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Section: Discussionsupporting

confidence: 76%

Effect of D-Allethrin Aerosol and Coil to the Mortality of Mosquitoes

Sayono

Mudawamah

Meikawati

et al. 2019

JAD

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“…aegypti PR strain showed moderate level of cross-resistance to metofluthrin, with RR of 30-fold and 15-fold for permethrin and metofluthrin, respectively. This result is similar with results from lab and field experiments reported by Chen et al (2018), Kuri-Morales et al (2018), and Gray et al (2018). Observed reductions in susceptibility are due to the long-term and inconsistent exposure of the mosquitoes to sub-lethal doses of the insecticide active ingredients used in different formulations, whether through space spraying, residual spraying, or vapor repellents (Kuri-Morales et al 2018, Gray et al 2018).…”

Section: Resultssupporting

confidence: 87%

“…albopictus among the compared pyrethroids in regards to KD and killing time (KT). There was considerable variation in mortalities (5-100%) and KT 50 (2.5-17 min), suggesting the presence of cross-resistance between the tested pyrethroids (Chen et al 2018). Metofluthrin impregnated nets inconsistently repelled Ae.…”

Section: Introductionmentioning

confidence: 98%

Insecticide Efficacy of Spatial Repellent Compound-Metofluthrin Against Susceptible and Resistant Strains of Aedes Aegypti

Khater¹

2021

J FL Mosq Control Assoc

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Spatial repellents (SR), include pyrethroid insecticides that are highly volatile at low temperatures and with high lethal activities against mosquitoes, mainly Aedes vectors of arboviral diseases. Of these SR, metofluthrin is widely used in various devices for repellent consumer products. This article reports the susceptibility status of Ae. aegypti Puerto Rico permethrin-resistant laboratory strain (PR) and Orlando susceptible laboratory strain (ORL) to metofluthrin and permethrin using the CDC glass bottle bioassay. The time-mortality relationships showed that the permethrin-resistant PR strain is highly resistant to both permethrin and metofluthrin compared to the susceptible ORL strain. The resistant ratio (RR) based on the killing time (KT) (KT50 -PR/KT50 -ORL) was 30- and 5- folds for permethrin and metofluthrin, respectively. The results also showed that the PR strain is less resistance to metofluthrin than to permethrin, with a three-fold RR (KT50 -PR-per/KT50 -PR-met). These results indicate the potential risk of developing cross-resistance of metofluthrin in permethrin-resistant mosquitoes. Integrated vector management in mosquito control should be considerate of how consumer products and field operations interact to accelerate cross resistance to pyrethroids.

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“…such as transfluthrin and d-allethrin under laboratory conditions, metofluthrin had greater chemical stability [ 29 ] and produced the highest Ae . albopictus mortality rate (> 80%) [ 30 ]. A manufactured passive emanator consisting of a fan-type paper device with a non-heated metofluthrin formula was highly effective against Ae .…”

Section: Introductionmentioning

confidence: 99%

Experimental evaluation of a metofluthrin passive emanator against Aedes albopictus

Vázquez-Prokopec

2022

PLoS ONE

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Background With the recent occurrence of locally transmitted Aedes-borne viruses in the continental United States and Europe, and a lack of effective vaccines, new approaches to control Aedes aegypti and Aedes albopictus are needed. In sub-tropical urban settings in the US, Ae. albopictus is a dominant nuisance and arbovirus vector species. Unfortunately, the vector control toolbox against Ae. albopictus is not as well developed as for Ae. aegypti. Here, we evaluate the efficacy, longevity, and range of protectiveness of a novel passive metofluthrin emanator (10% active ingredient in a polyethylene mesh) against Ae. albopictus indoors and outdoors. Methods Four studies were conducted comparing the presence of the metofluthrin emanator to a control lacking emanator with interest in quantifying efficacy by human landing counts. Studies evaluated the effect of an emanator at varying distances from one or more human volunteers indoors and outdoors. Efficacy of emanators over time since activation was also evaluated. Results Mixed-effects models determined that sitting in close proximity to an emanator reduced landings by 89.5% outdoors and by 74.6% indoors. The emanator was determined protective when located immediately next to a human volunteer outdoors but not uniformly protective when located further away. The emanator was protective at all tested distances from the device indoors. Mortality of mosquitoes exposed to metofluthrin emanators was ~2x higher than those who were not exposed in indoor conditions. Finally, a Generalized Additive Model determined that emanators used continuously outdoors lost their effect after 2.5 weeks and stopped inducing paralysis in mosquitoes after 3.8 weeks of use. Conclusions We show strong and lasting efficacy of 10% metofluthrin emanators against field Ae. albopictus both in indoor and outdoor conditions. Metofluthrin emanators can protect people from Ae. albopictus bites, representing a viable option for reducing human-mosquito contacts at home and beyond.

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Bioefficacy Evaluation of Commercial Mosquito Coils Containing Metofluthrin, d-Allethrin, d-Trans Allethrin, and Prallethrin Against Aedes albopictus (Diptera: Culicidae) in Malaysia

Cited by 8 publications

References 14 publications

Effect of D-Allethrin Aerosol and Coil to the Mortality of Mosquitoes

Effect of D-Allethrin Aerosol and Coil to the Mortality of Mosquitoes

Insecticide Efficacy of Spatial Repellent Compound-Metofluthrin Against Susceptible and Resistant Strains of Aedes Aegypti

Experimental evaluation of a metofluthrin passive emanator against Aedes albopictus

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