Pyridinecarboxamide and neonicotinoids insecticides are used in small quantity and economically effective for control sucking pests in cotton fields. Therefore, the current study was conducted to evaluate the efficiency of flonicamid, imidacloprid and dinotefuran and its compared with abamectin, carbosulfan, malathion and cholorpyrifos against cotton aphids, Aphis gossypii Glover and whitefly, Bemisia tabaci (Genn.) and its associated predators, Chrysoperle carnea (larvae and adults) and spiders in cotton fields at Sakha Agricultural Research Station, Kafr El-Sheikh Governorate, Egypt during 2017 and 2018 cotton seasons. Seven insecticides were applied at their field recommended rates. The obtained results proved that imidacloprid, flonicamid and dinotefuran were recorded the highest mean reduction of aphids (92.95, 86.36 and 76.16%) at 2017 and (90.95, 82.48 and 78.44%) at 2018 season. Carbosulfan and chlorpyrifos caused moderate effective against Aphis gossypii, while the least effective compound was malathion. Concerning the whitefly, imidacloprid, flonicamid and dinotefuran statistically exhibited reduction in populations of adults' stage ranged from 67.54-78.46% in 2017 and 2018 seasons and 71.04-87.26% reduction in immature stages in both seasons, while carbosulfan was the least effective compound against Bemisia tabaci (adult and immature stages). It is important to note that flonicamid, imidacloprid and dinotefuran were less harmful effect on populations of tested predators than the tested organophosphates and cabosulfan. Accordingly, flonicamid, imidacloprid and dinotefuran are useful choice for use in IPM programs to control these pests in cotton fields.