Bioelectric Medicine and Devices for the Treatment of Spinal Cord Injury

Torregrosa, Tess; Koppes, Ryan A.

doi:10.1159/000446698

Cited by 7 publications

(2 citation statements)

References 183 publications

(162 reference statements)

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“…Taken together, these results support the successful formation of the Shell@ PDA-GO. Bioelectricity is a manifestation of normal physiological activity and is the primary biological characteristic of living tissues [26]. Under the conductive microenvironment, the spinal cord can transmit bioelectric signals between the brain and peripheral organs via electrically excitable nerve fibers.…”

Section: Materials Preparation and Characterization Analysismentioning

confidence: 99%

Mussel shell-derived pro-regenerative scaffold with conductive porous multi-scale-patterned microenvironment for spinal cord injury repair

Yin,

Yang,

Liu

et al. 2024

Biomed. Mater.

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It is well-established that multi-scale porous scaffolds can guide axonal growth and facilitate functional restoration after spinal cord injury (SCI). In this study, we developed a novel mussel shell-inspired conductive scaffold for SCI repair with ease of production, multi-scale porous structure, high flexibility, and excellent biocompatibility. By utilizing the reducing properties of polydopamine, non-conductive graphene oxide (GO) was converted into conductive reduced graphene oxide (rGO) and crosslinked in situ within the mussel shells. In vitro experiments confirmed that this multi-scale porous Shell@PDA-GO could serve as structural cues for enhancing cell adhesion, differentiation, and maturation, as well as promoting the electrophysiological development of hippocampal neurons. After transplantation at the injury sites, the Shell@PDA-GO provided a pro-regenerative microenvironment, promoting endogenous neurogenesis, triggering neovascularization, and relieving glial fibrosis formation. Interestingly, the Shell@PDA-GO could induce the release of endogenous growth factors (NGF and NT-3), resulting in the complete regeneration of nerve fibers at 12 weeks. This work provides a feasible strategy for the exploration of conductive multi-scale patterned scaffold to repair SCI.

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Section: Materials Preparation and Characterization Analysismentioning

confidence: 99%

Mussel shell-derived pro-regenerative scaffold with conductive porous multi-scale-patterned microenvironment for spinal cord injury repair

Yin,

Yang,

Liu

et al. 2024

Biomed. Mater.

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“…There are technologies of exo-skeleton, electrophysiological stimulation, and brain-computer-interface-based prosthesis undergoing development and preclinical experiments. [5][6][7][8] However, from the patients' and families' standpoint, regenerative medicine is still the place where they send their hopes.…”

Section: Introductionmentioning

confidence: 99%

Acidic Fibroblast Growth Factor in Spinal Cord Injury

Ko¹,

Tu²,

Wu³

et al. 2019

Neurospine

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Spinal cord injury (SCI), with an incidence rate of 246 per million person-years among adults in Taiwan, remains a devastating disease in the modern day. Elderly men with lower socioeconomic status have an even higher risk for SCI. Despite advances made in medicine and technology to date, there are few effective treatments for SCI due to limitations in the regenerative capacity of the adult central nervous system. Experiments and clinical trials have explored neuro-regeneration in human SCI, encompassing cell-and molecule-based therapies. Furthermore, strategies have aimed at restoring connections, including autologous peripheral nerve grafts and biomaterial scaffolds that theoretically promote axonal growth. Most molecule-based therapies target the modulation of inhibitory molecules to promote axonal growth, degrade glial scarring obstacles, and stimulate intrinsic regenerative capacity. Among them, acidic fibroblast growth factor (aFGF) has been investigated for nerve repair; it is mitogenic and pluripotent in nature and could enhance axonal growth and mitigate glial scarring. For more than 2 decades, the authors have conducted multiple trials, including human and animal experiments, using aFGF to repair nerve injuries, including central and peripheral nerves. In these trials, aFGF has shown promise for neural regeneration, and in the future, more trials and applications should investigate aFGF as a neurotrophic factor. Focusing on aFGF, the current review aimed to summarize the historical evolution of the utilization of aFGF in SCI and nerve injuries, to present applications and trials, to summarize briefly its possible mechanisms, and to provide future perspectives.

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