Bioelectricity: A Top-Down Control Model to Promote More Effective Aging Interventions

Anderson, Benjamin

doi:10.1089/bioe.2023.0013

Bioelectricity

2024

DOI: 10.1089/bioe.2023.0013

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Bioelectricity: A Top-Down Control Model to Promote More Effective Aging Interventions

Benjamin Anderson¹

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2024

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Charging Ahead: Examining the Future Therapeutic Potential of Electroceuticals

Balasubramanian,

Weston,

Levin

et al. 2024

Advanced Therapeutics

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Electroceuticals derived from electronic and pharmaceuticals is a term coined to describe the therapeutic manipulation of neuronal signaling. In recent years, the sophistication and range of applications of electroceuticals has grown considerably. In this Review we therefore suggest a revised ontology and framework for defining electroceuticals that broadens the concept beyond neuron‐targeted interventions. This more inclusive framework aims to provide greater coherence and bring together different stakeholders to accelerate progress in this field. We suggest that electroceuticals can be categorised according to the level of physiology for which they act: cellular, tissue, organ and systemic. We discuss emerging developments for each category of electroceutical and future directions from a pharmaceutical industry perspective. We also highlight potential challenges for translation of electroceuticals, such as a lack of clinical biomarkers and incomplete understanding of mechanisms of action and offer solutions for stimulating progress in this exciting field.This article is protected by copyright. All rights reserved

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Charging Ahead: Examining the Future Therapeutic Potential of Electroceuticals

Balasubramanian,

Weston,

Levin

et al. 2024

Advanced Therapeutics

View full text Add to dashboard Cite

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The Biochemical Basis of Aging

Yılmazer

2024

NFLSAI

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Aging is a complex biological process driven by intricate biochemical mechanisms that affect cellular function, tissue integrity, and systemic homeostasis. Central to the biochemical basis of aging are phenomena such as oxidative stress, telomere shortening, epigenetic alterations, and the accumulation of damaged macromolecules. These processes lead to gradual functional decline and increased susceptibility to age-related diseases. Emerging research highlights the pivotal roles of mitochondrial dysfunction, proteostasis imbalance, and chronic inflammation in accelerating the aging process. Furthermore, interventions targeting these pathways—such as caloric restriction, senolytic therapies, and the use of pharmacological agents like rapamycin—offer promising avenues for modulating aging and extending healthspan. This paper explores the molecular pathways underlying aging, their implications for health and longevity, and potential therapeutic strategies. By uncovering the biochemical mechanisms that govern aging, this study aims to contribute to the development of interventions that promote healthier aging.

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Bioelectricity: A Top-Down Control Model to Promote More Effective Aging Interventions

Cited by 2 publications

References 59 publications

Charging Ahead: Examining the Future Therapeutic Potential of Electroceuticals

Charging Ahead: Examining the Future Therapeutic Potential of Electroceuticals

The Biochemical Basis of Aging

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