Bioelectroanalysis of pharmaceutical compounds

Cavalheiro, Éder Tadeu Gomes; Brett, Christopher M. A.; Oliveira‐Brett, Ana Maria; Fatibello‐Filho, Orlando

doi:10.1007/978-3-642-36303-0_12

Cited by 5 publications

(5 citation statements)

References 261 publications

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“…After polishing, the electrode was immersed in ethanol absolute and abundantly washed with deionized water. Finally, the polished electrode was submitted to potential cycles at scan rate 25 mV s −1 in a potential range from −1.0 to +1.0 V vs. SCE in 0.1 mol L −1 H 2 SO 4 solution until to obtain a stable voltammetric profile [31,32]. The electrode surface was coated with multiple additions of 10 L of 0.1% w/v PtNPs/C in DMF.…”

Section: Preparation Of Electrochemical Sensing Platformmentioning

confidence: 99%

Construction of an electrochemical sensing platform based on platinum nanoparticles supported on carbon for tetracycline determination

Kushikawa

Silva

Angelo

et al. 2016

Sensors and Actuators B: Chemical

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a b s t r a c tIn this paper, we report the construction of an electrochemical sensing platform based on platinum nanoparticles supported on carbon (PtNPs/C) for the determination of the antibiotic tetracycline (TTC). Initially, the PtNPs/C was synthesized and characterized by powder X-ray diffraction spectroscopy and transmission electron microscopy. The effect of experimental parameters on the electrochemical behavior of the PtNPs/C coated glassy carbon electrode (PtNPs/C/GCE), including the amount of PtNPs and electroactive area, scan rate and pH, were evaluated. The electrooxidation of TTC on the PtNPs/C/GCE was investigated by cyclic voltammetry and differential pulse voltammetry, with the determination of TTC electrooxidation mechanism. Under optimum experimental conditions, the linear calibration range, detection limit, quantification and sensitivity of the PtNPs/C/GCE were 9.99-44.01 mol L −1 , 4.28 mol L −1 , 14.3 mol L −1 and 3.32 A L mol −1 cm −2 , respectively. Finally, the proposed electrochemical sensing platform was successfully applied to determine low TTC concentrations in urine samples, suggesting its great applicability in clinical analysis and quality control.

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Section: Preparation Of Electrochemical Sensing Platformmentioning

confidence: 99%

Construction of an electrochemical sensing platform based on platinum nanoparticles supported on carbon for tetracycline determination

Kushikawa

Silva

Angelo

et al. 2016

Sensors and Actuators B: Chemical

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“…however, no method has been reported for the simultaneous estimation of ciprofloxacin, clindamycin phosphate and metronidazole in pharmaceutical mixture. [59], capillary electrophoresis [60], chemi-luminescence [61], electrochemiluminescence [62], electrochemistry [63] and electrochemical sensors [64,65]. To date, to the best of our knowledge, there is no reported thin-layer chromatography (TLC)densitometry method for the simultaneous determination mixture of CIP, CLI and MET.…”

Section: Introductionmentioning

confidence: 99%

Novel Rapid Validated TLC- Densitometry for the Simultaneous Determination of Three Co-formulated Drugs used for Deep Tooth Inflammation Treatment

Marouf

Kawas

Sakur

2021

IRJPAC

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A new use of a tertiary antibiotic combination of ciprofloxacin, clindamycin and metronidazole is currently being studied as an intracranial (intracranial) drug in an effort to disinfect the root canal system to revitalize the tooth with dead pulp. It is necessary to developing analytical method for the new drug combination. Herein we developed a rapid validated thin-layer chromatography (TLC)‒densitometric method has been developed for the simultaneous determination of 3 co-formulated drugs used for deep tooth inflammation Treatment. The studied drugs are Ciprofloxacin.HCL (CIP), Clindamycin phosphate (CLI) and Metronidazole(MET). The separation was achieved by using silica gel 60 F254 plates (20*20 cm) as stationary Phase and the developing system of Dichloromethane:n-Hexane:methanol:Ethylamine:Triethylamine (40:20:32:3:5)v/v. Densitometry scanning was performed at 220 nm. The Rf values of CIP, CLI and MET were found to be 0.588, 0.776 and 0.898 respectively. The method was validated as per the International Conference on Harmonization (ICH) guidelines and was successfully applied for the analysis of ternary lab made mixture, containing the cited ternary mixture without interference from excipients. There is no previously published TLC–densitometry method for the determination of the previously mentioned ternary mixture. The suggested method is novel, rapid, accurate, reproducible and of low cost, so; thus, it can be used for quality control analysis of these formulations.

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“…The use of a standard addition of EP in the CSF solution containing the ascorbic acid allowed minimizing such interference. Open Access polyurethane composite previously used as conventional disk working electrode in the determination of many analytes, as recently reviewed [25] while here the material was used to construct the printed device as well as the electrical contacts of the SPE.…”

Section: Introductionmentioning

confidence: 99%

Determination of Epinephrine at a Screen-Printed Composite Electrode Based on Graphite and Polyurethane

Iarb¹,

Tr²,

Cervini³

et al. 2017

J Anal Bioanal Tech

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Bioelectroanalysis of pharmaceutical compounds

Cited by 5 publications

References 261 publications

Construction of an electrochemical sensing platform based on platinum nanoparticles supported on carbon for tetracycline determination

Construction of an electrochemical sensing platform based on platinum nanoparticles supported on carbon for tetracycline determination

Novel Rapid Validated TLC- Densitometry for the Simultaneous Determination of Three Co-formulated Drugs used for Deep Tooth Inflammation Treatment

Determination of Epinephrine at a Screen-Printed Composite Electrode Based on Graphite and Polyurethane

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