Introduction. The most popular education in Russian higher education institutions is enjoyed by immigrants from Central Asian countries, including Kazakhstan, Tajikistan, Turkmenistan, Uzbekistan and Kyrgyzstan. They account for more than half of all foreign citizens studying in Russian universities. Changed environmental conditions lead to the development of stressful situations, decreased learning ability and, in the future, the possible development of a number of diseases closely associated with the presence of various elementoses. In this regard, in addition to the socio-cultural adaptation of students, it is very important to pay attention to the study of the elemental status of students in the process of their further adaptation to the changed living conditions. The purpose of the study – comparative analysis of iron, copper, cobalt content in hair, blood serum and urine of students from Central Asian countries, the Middle East and Central Russian regions during the adaptation period to study. Material and methods. In the period from September 1, 2022 to January 1, 2023, a study of the elemental composition of hair was conducted using inductively coupled plasma mass spectrometry in 180 first-year students of RUDN University, who previously lived in the countries of Central Asia (170 people), the Middle East (60 people) and in the regions of Central Russia (120 people) aged 18–26 years. The average age of the subjects was 22.7 ± 4 years. Gender differences in the comparison groups were not taken into account. Differences in samples were determined using the Mann–Whitney test for independent samples (significance level p < 0.05). Results. The article presents the results of a comparative analysis of the content of iron, copper, chromium in the hair, urine and blood serum of students who arrived from the countries of the Middle East, Central Asia and the regions of Central Russia during the adaptation period to study in 2023. Features of the elemental profiles of students were established. Conclusions. It is shown that the hair of the subjects reflects the territorial climatic and geographical features of the region of residence of the examined persons. Despite statistically significant differences in the content of iron, copper, chromium in the examined students of different regions, their elemental profile did not affect the objective medical indicators (heart rate, saturation level, hemoglobin index).