Medical Biochemistry 2009
DOI: 10.1016/b978-0-323-05371-6.00009-7
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Bioenergetics and Oxidative Metabolism

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Cited by 2 publications
(4 citation statements)
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“…While UCP1 is exclusive to brown adipose tissue, UCP2 is expressed ubiquitously, UCP3 is mainly expressed in skeletal muscle, and UCP4 and UCP5 are expressed in the brain (14). The physiological functions of these proteins are not well understood, but could have profound significance in our understanding of conditions such as diabetes, obesity, thyroid disease, and aging.…”
Section: Anatomy Physiology and Pathology Of Batmentioning
confidence: 99%
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“…While UCP1 is exclusive to brown adipose tissue, UCP2 is expressed ubiquitously, UCP3 is mainly expressed in skeletal muscle, and UCP4 and UCP5 are expressed in the brain (14). The physiological functions of these proteins are not well understood, but could have profound significance in our understanding of conditions such as diabetes, obesity, thyroid disease, and aging.…”
Section: Anatomy Physiology and Pathology Of Batmentioning
confidence: 99%
“…The physiological functions of these proteins are not well understood, but could have profound significance in our understanding of conditions such as diabetes, obesity, thyroid disease, and aging. Thyroid hormone, an important regulator of energy expenditure, is not only necessary for the full expression of UCP1, but also induces UCP3 expression and UCP3-mediated uncoupling in skeletal muscle mitochondria of rodents (14). …”
Section: Anatomy Physiology and Pathology Of Batmentioning
confidence: 99%
“…This reaction takes up two protons from the mitochondrial matrix and transfers four protons to the other side of the mitochondrial membrane. Antimycin A, an ETC complex III inhibitor, prevents electrons from transferring from Complex I or FADH2 to Cyt-c [ 50 ]. During HCMV infection, a single dose of Antimycin A given 2 h post infection resulted in a 2-log reduction in HCMV titers using HCMV TR, but only a 0.5-log change using HCMV Towne [ 20 ].…”
Section: Etc and Its Role In Hcmv Replicationmentioning
confidence: 99%
“…Oligomycin differs from other ETC inhibitors because it targets the proton channel of ATP synthase as opposed to directly inhibiting the ETC [ 50 ]. Oligomycin binds to a subunit of ATP synthase, preventing protons from passing back into the mitochondria and creating an unfavorable proton gradient for its operation [ 50 , 54 ]. The TCA cycle cannot adequately operate under these conditions, because NADH remains high and NAD + is too low [ 54 ].…”
Section: Etc and Its Role In Hcmv Replicationmentioning
confidence: 99%