Bioenergetics of human spermatozoa in patients with testicular germ cell tumour
Ondrej Simonik,
Barbora Bryndova,
Vishma Pratap Sur
et al.
Abstract:In testicular germ cell tumour (TGCT) patients, sperm cryopreservation prior to anti-cancer treatment represents the main fertility preservation approach. However, it is associated with low sperm recovery rate after thawing. Since sperm is a high-energy demanding cell, which is supplied by glycolysis and oxidative phosphorylation (OXPHOS), mitochondrial dysfunctionality can directly result in sperm anomalies. In this study, we investigated the bioenergetic pattern of cryopreserved sperm of TGCT patients in com… Show more
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