2020
DOI: 10.1183/13993003.01200-2019
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Bioengineered airway epithelial grafts with mucociliary function based on collagen IV- and laminin-containing extracellular matrix scaffolds

Abstract: Current methods to replace damaged upper airway epithelium with exogenous cells are limited. Existing strategies use grafts that lack mucociliary function, leading to infection and the retention of secretions and keratin debris. Strategies that regenerate airway epithelium with mucociliary function are clearly desirable and would enable new treatments for complex airway disease.Here, we investigated the influence of the extracellular matrix (ECM) on airway epithelial cell adherence, proliferation and mucocilia… Show more

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Cited by 33 publications
(27 citation statements)
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“…Other studies have also shown that the adipose tissue-derived ECM possess tremendous therapeutic potential for skin repair [66]. Furthermore, tissue-engineered grafts rich in laminin and collagen IV is also of interest for respiratory epithelium repair [67].…”
Section: Discussionmentioning
confidence: 99%
“…Other studies have also shown that the adipose tissue-derived ECM possess tremendous therapeutic potential for skin repair [66]. Furthermore, tissue-engineered grafts rich in laminin and collagen IV is also of interest for respiratory epithelium repair [67].…”
Section: Discussionmentioning
confidence: 99%
“…Clinical applications of cultured autologous cells have been limited. In tissue-engineered grafts used in airway transplantation cases (121,122), the epithelial components are not thought to have engrafted, with any epithelialization instead attributed to in-growth from surrounding host cells (123); this view is supported by difficulties in engrafting airway epithelium in pre-clinical models (124). Two bronchiectasis patients also received cultured basal cells via bronchoscopy in a pilot clinical study (125); the fate of these cells is unknown and additional pre-clinical work is required before further human trials.…”
Section: Cell Therapymentioning
confidence: 99%
“…2 ). Collagen IV has been shown to support airway epithelial cell attachment, proliferation and differentiation, whereas laminin has been shown to promote migration of epithelial cells [82] , [83] . Increased BM thickness beneath the epithelium has been suggested to act as an additional barrier against penetration of foreign particles.…”
Section: Role Of Bm Proteins In Obstructive Airway Diseasesmentioning
confidence: 99%