Bioengineered Braided Micro–Nano (Multiscale) Fibrous Scaffolds for Tendon Reconstruction

Jayasree, Anjana; Thankappan, Shalumon Kottappally; Ramachandran, Retheesh; Sundaram, M. Nivedhitha; Chen, Chih‐Hao; Mony, Ullas; Chen, Jyh-Ping; Rangasamy, Jayakumar

doi:10.1021/acsbiomaterials.8b01328

Cited by 43 publications

(37 citation statements)

References 43 publications

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“…Recently, Jayasree et al have engineered a braided multiscale fibrous scaffold consisting of aligned PCL micro/collagen-bFGF nanofibers, and this scaffold showed enhanced tendon regeneration when subjected to dynamic stimulation both in vitro and in vivo. 54 Additionally, assembling multiple bundles or yarns is also a promising approach to mimic the hierarchical structure of tissues. Sensini et al developed a versatile method to biofabricate a scaffold consisting of multiple electrospun nanofibrous bundles of PLLA, obtained by wrapping the aligned mats in a sheath, which replicated the hierarchical arrangement in the natural tendons and ligaments.…”

Section: Resultsmentioning

confidence: 99%

Bioinspired bimodal micro-nanofibrous scaffolds promote the tenogenic differentiation of tendon stem/progenitor cells for achilles tendon regeneration

et al. 2022

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Section: Resultsmentioning

confidence: 99%

Bioinspired bimodal micro-nanofibrous scaffolds promote the tenogenic differentiation of tendon stem/progenitor cells for achilles tendon regeneration

et al. 2022

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“…Results revealed tenocyte viability, growth and expression of tenogenic markers in vitro, while oriented collagen formation was observed in a rabbit model in vivo. [ 202 ] On the other hand, Chainani et al. fabricated a multilayered electrospun PCL scaffold coated by tendon‐derived matrix (TDM), and evaluated the biological response of human adipose‐derived stem cells (hASCs).…”

Section: Fiber‐based Engineered Scaffolds For Tendons and Ligamentsmentioning

confidence: 99%

Fibrous Systems as Potential Solutions for Tendon and Ligament Repair, Healing, and Regeneration

Rinoldi

Kijeńska‐Gawrońska

Khademhosseini

et al. 2021

Adv Healthcare Materials

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Tendon and ligament injuries caused by trauma and degenerative diseases are frequent and affect diverse groups of the population. Such injuries reduce musculoskeletal performance, limit joint mobility, and lower people's comfort. Currently, various treatment strategies and surgical procedures are used to heal, repair, and restore the native tissue function. However, these strategies are inadequate and, in some cases, fail to re‐establish the lost functionality. Tissue engineering and regenerative medicine approaches aim to overcome these disadvantages by stimulating the regeneration and formation of neotissues. Design and fabrication of artificial scaffolds with tailored mechanical properties are crucial for restoring the mechanical function of tendons. In this review, the tendon and ligament structure, their physiology, and performance are presented. On the other hand, the requirements are focused for the development of an effective reconstruction device. The most common fiber‐based scaffolding systems are also described for tendon and ligament tissue regeneration like strand fibers, woven, knitted, braided, and braid‐twisted fibrous structures, as well as electrospun and wet‐spun constructs, discussing critically the advantages and limitations of their utilization. Finally, the potential of multilayered systems as the most effective candidates for tendon and ligaments tissue engineering is pointed out.

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“…Gelatin (Gel), polycaprolactone (PCL), silk fibroin (SF), polylactic acid (PLA), hyaluronic acid (HA), and bacterial cellulose (BC). Electrospinning Various biomaterials [12,14,24,[59][60][61][62][63][64] • Applicable to various biomaterials • Ease of use • Slow cell infiltration…”

Section: Aligned Building Blocks Fabrication Techniquesmentioning

confidence: 99%

Engineering Complex Anisotropic Scaffolds beyond Simply Uniaxial Alignment for Tissue Engineering

Xing

Liu

Xu³

et al. 2021

Adv Funct Materials

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Anisotropic microarchitectures arising from an aligned organization of threadlike extracellular matrix (ECM) components or cells are ubiquitous in the human body, such as skeletal muscle, corneal stroma, and meniscus, for executing tissue-specific physiological functions. It is widely recognized that tissue engineering, whereby growing the implanted or endogenous cells in anisotropic scaffolds with geometrical resemblance to the ECM of targeted tissues, represents a promising solution for the structural and functional restoration of these anisotropic tissues. However, remarkable challenges remain in recapitulating the anisotropic complexities of native tissues beyond simply uniaxial alignment. Through unremitting endeavors over the past decade, some innovative bioengineering approaches are developed to tackle these challenges. This review focuses on the recent progress in modular assembly and 3D printing techniques exploited to construct complex anisotropic scaffolds with a key highlight on their accessibility and features for different types of anisotropies, based on understanding the whole picture of anisotropies beyond simply uniaxial alignment in native tissues, which are geometrically divided into three categories. Finally, the applications of these complex scaffolds in anisotropic tissue engineering, either in vitro modeling or in vivo regeneration, are explored.

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Bioengineered Braided Micro–Nano (Multiscale) Fibrous Scaffolds for Tendon Reconstruction

Cited by 43 publications

References 43 publications

Bioinspired bimodal micro-nanofibrous scaffolds promote the tenogenic differentiation of tendon stem/progenitor cells for achilles tendon regeneration

Bioinspired bimodal micro-nanofibrous scaffolds promote the tenogenic differentiation of tendon stem/progenitor cells for achilles tendon regeneration

Fibrous Systems as Potential Solutions for Tendon and Ligament Repair, Healing, and Regeneration

Engineering Complex Anisotropic Scaffolds beyond Simply Uniaxial Alignment for Tissue Engineering

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