Bioengineered Tissues for Urogenital Repair in Children

Atala, Anthony

doi:10.1203/pdr.0b013e3181660639

Cited by 57 publications

(43 citation statements)

References 70 publications

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“…20 Moreover, the inflammatory reaction elicited after scaffold implantation and associated with the plasticity of BMDC would generate a local microenvironment that favors tissue remodeling and repair. 21 As we hypothesized that cell therapy could be more effective if administered during less severe stages of the disease, we evaluated the effectiveness of treatment in rats sustained by a remnant renal mass two-fold greater than that of the traditional 5/6 model using the 2/3 reduction of renal mass model.…”

Section: Discussionmentioning

confidence: 99%

Effect of stem cells seeded onto biomaterial on the progression of experimental chronic kidney disease

Caldas

Fernandes

Kawasaki-Oyama

et al. 2011

Exp Biol Med (Maywood)

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Different routes for the administration of bone marrow-derived cells (BMDC) have been proposed to treat the progression of chronic renal failure (CRF). We investigated whether (1) the use of bovine pericardium (BP) as a scaffold for cell therapy would retard the progression of CRF and (2) the efficacy of cell therapy differently impacts distinct degrees of CRF. We used 2/3 and 5/6 models of renal mass reduction to simulate different stages of chronicity. Treatments consisted of BP seeded with either mesenchymal or mononuclear cells implanted in the parenchyma of remnant kidney. Renal function and proteinuria were measured at days 45 and 90 after cell implantation. BMDC treatment reduced glomerulosclerosis, interstitial fibrosis and lymphocytic infiltration. Immunohistochemistry showed decreased macrophage accumulation, proliferative activity and the expression of fibronectin and α-smooth muscle-actin. Our results demonstrate: (1) biomaterial combined with BMDC did retard the progression of experimental CRF; (2) cellular therapy stabilized serum creatinine (sCr), improved creatinine clearance and 1/sCr slope when administered during the less severe stages of CRF; (3) treatment with combined therapy decreased glomerulosclerosis, fibrosis and the expression of fibrogenic molecules; and (4) biomaterials seeded with BMDC can be an alternative route of cellular therapy.

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Section: Discussionmentioning

confidence: 99%

Effect of stem cells seeded onto biomaterial on the progression of experimental chronic kidney disease

Caldas

Fernandes

Kawasaki-Oyama

et al. 2011

Exp Biol Med (Maywood)

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“…Repair of hypospadias, a congenital abnormality of the urethra, is associated with complications such as fistula, stenosis, urethrocele, persistence or recurrence of chordee, hair growth, stricture, dehiscence, and diverticula formation [11][12][13][14]. Hence, regenerative medicine has opened new doors for treatment of many urologic problems [15][16][17][18]. Urethral replacement procedures also may involve the use of synthetic biomaterials.…”

Section: Urethral Repairmentioning

confidence: 99%

Genitourinary System

Abolbashari

Atala

Yoo

2015

Translational Regenerative Medicine

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“…69 The use of the reconstructed neobladders created with PGA-collagen cell-seeded scaffolds was reflected by an increased compliance, decreased end-filling pressures, increased capacities, and longer dry periods. 70 Despite the unequivocal importance of this seminal clinical study, the implanted neobladders lacked the normal innervation required for micturition and thus provided a neoreservoir, rather than a functional bladder. Nonetheless, this study represented a critical advance for the field and laid the groundwork required for additional clinical studies (see the Tengion Web site, , for more details on the latest clinical trials).…”

Section: Implantation Of a Laboratory-grown Neobladder: "State Of Thementioning

confidence: 99%

Regenerative Medicine

Corona

Ward

Harrison

et al. 2010

Journal of Investigative Medicine

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A recent report demonstrated that a laboratory-grown neobladder tissue could be successfully used for cystoplasty in young patients with myelomeningocele who were otherwise healthy. This remarkable achievement portends well for the application of tissue engineering/regenerative medicine technologies to the treatment of end-organ failure due to a variety of causes (ie, congenital, acquired, age or disease related). Nonetheless, the broader clinical use of these groundbreaking technologies awaits improved understanding of endogenous regenerative mechanisms, more detailed knowledge of the boundary conditions that define the current limits for tissue repair and replacement in vivo, and the parallel development of critical enabling technologies (ie, improved cell source, biomaterials, bioreactors). This brief report will review a number of the most salient features and recent developments in this rapidly advancing area of medical research and detail some of our own experience with bladder and skeletal muscle regeneration and replacement as examples that highlight both the promise and challenges facing regenerative medicine/tissue engineering.

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Bioengineered Tissues for Urogenital Repair in Children

Abstract: ABSTRACT:The most common congenital abnormalities involve the genitourinary system. These include hypospadias, in which the urethral opening develops in an improper position, and bladder exstrophy, in which the bladder develops on the outer surface of the abdomen.

Cited by 57 publications

References 70 publications

Effect of stem cells seeded onto biomaterial on the progression of experimental chronic kidney disease

Effect of stem cells seeded onto biomaterial on the progression of experimental chronic kidney disease

Genitourinary System

Regenerative Medicine

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