Bioengineering Approaches for Delivering Growth Factors: A Focus on Bone and Cartilage Regeneration

Shakoor, Sheeba; Kibble, Eleyna; El-Jawhari, Jehan J.

doi:10.3390/bioengineering9050223

Cited by 11 publications

(6 citation statements)

References 84 publications

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“… 117 Scaffolds such as hydrogels, sponges, and nanofiber-based structures offer the ability to tailor the release kinetics of PRP-derived growth factors. 118 Thus, the choice of scaffold material can influence factors like degradation rate, which, in turn, affects the release profile of PRP components. Hydrogels and sponges, composed of materials such as alginate and gelatin, have demonstrated their efficacy as delivery systems for PRP in bone regeneration.…”

Section: Delivery: Tailoring Application Methodsmentioning

confidence: 99%

Advances with Platelet-Rich Plasma for Bone Healing

Bacevich,

Smith,

Reihl

et al. 2024

BTT

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Despite significant advances in the understanding and delivery of osteosynthesis, fracture non-union remains a challenging clinical problem in orthopaedic surgery. To bridge the gap, basic science characterization of fracture healing provides a platform to identify and target biological strategies to enhance fracture healing. Of immense interest, Platelet-rich plasma (PRP) is a point of care orthobiologic that has been extensively studied in bone and soft tissue healing given its relative ease of translation from the benchtop to the clinic. The aim of this narrative review is to describe and relate pre-clinical in-vitro and in-vivo findings to clinical observations investigating the efficacy of PRP to enhance bone healing for primary fracture management and non-union treatment. A particular emphasis is placed on the heterogeneity of PRP preparation techniques, composition, activation strategies, and delivery. In the context of existing data, the routine use of PRP to enhance primary fracture healing and non-union management cannot be supported. However, it is acknowledged that extensive heterogeneity of PRP treatments in clinical studies adds obscurity; ultimately, refinement (and consensus) of PRP treatments for specific clinical indications, including repetition studies are warranted.

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Section: Delivery: Tailoring Application Methodsmentioning

confidence: 99%

Advances with Platelet-Rich Plasma for Bone Healing

Bacevich,

Smith,

Reihl

et al. 2024

BTT

View full text Add to dashboard Cite

show abstract

“…Biological adjuncts, such as platelet-rich plasma (PRP), mesenchymal stem cell therapy, and tissueengineered scaffolds, hold promise for promoting tissue regeneration, reducing inflammation, and accelerating recovery in complex musculoskeletal injuries [50].…”

Section: Biological Augmentation and Tissue Engineeringmentioning

confidence: 99%

Advances in Understanding and Managing Floating Knee Injuries: A Comprehensive Review

Yadav,

Rawal

2024

Cureus

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Fractures of the ipsilateral tibia and femur, frequently combined with soft tissue damage and dislocations, describe floating knee injuries, a complicated orthopedic condition. Epidemiological data suggest that floating knee injuries account for a small but significant proportion of traumatic orthopedic injuries, with a higher incidence observed in younger males engaged in high-risk activities. Anatomically, floating knee injuries involve fractures of the femur and tibia, ligamentous disruptions, and soft tissue damage, contributing to the complexity and severity of these injuries. An extensive analysis of floating knee injuries is given in this paper, including information about epidemiology, anatomy, pathophysiology, categorization, management approaches, complications, prognosis, and current and upcoming developments.

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“…In the latter case, the scaffold properties, such as permeability, stiffness, surface chemistry and adhesive moieties, are essential in mimicking the cell’s microenvironment. Specific biologically active molecules, such as growth factors and hormones, can be encapsulated inside some types of scaffolds to improve and stimulate cell growth and proliferation [ 109 , 110 ].…”

Section: Three-dimensional Cellular Models For Radiobiological Studie...mentioning

confidence: 99%

3D Cell Models in Radiobiology: Improving the Predictive Value of In Vitro Research

Antonelli

2023

IJMS

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Cancer is intrinsically complex, comprising both heterogeneous cellular composition and extracellular matrix. In vitro cancer research models have been widely used in the past to model and study cancer. Although two-dimensional (2D) cell culture models have traditionally been used for cancer research, they have many limitations, such as the disturbance of interactions between cellular and extracellular environments and changes in cell morphology, polarity, division mechanism, differentiation and cell motion. Moreover, 2D cell models are usually monotypic. This implies that 2D tumor models are ineffective at accurately recapitulating complex aspects of tumor cell growth, as well as their radiation responses. Over the past decade there has been significant uptake of three-dimensional (3D) in vitro models by cancer researchers, highlighting a complementary model for studies of radiation effects on tumors, especially in conjunction with chemotherapy. The introduction of 3D cell culture approaches aims to model in vivo tissue interactions with radiation by positioning itself halfway between 2D cell and animal models, and thus opening up new possibilities in the study of radiation response mechanisms of healthy and tumor tissues.

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Bioengineering Approaches for Delivering Growth Factors: A Focus on Bone and Cartilage Regeneration

Cited by 11 publications

References 84 publications

Advances with Platelet-Rich Plasma for Bone Healing

Advances with Platelet-Rich Plasma for Bone Healing

Advances in Understanding and Managing Floating Knee Injuries: A Comprehensive Review

3D Cell Models in Radiobiology: Improving the Predictive Value of In Vitro Research

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