Bioengineering lungs: An overview of current methods, requirements, and challenges for constructing scaffolds

Shakir, Shahad; Hackett, Tillie L.; Mostaço-Guidolin, Leila B.

doi:10.3389/fbioe.2022.1011800

Cited by 12 publications

(7 citation statements)

References 85 publications

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“…The biological scaffold technique carries the risk of infection; furthermore, its use is limited by the shortage of donor lungs. To combat this, in the future, we may have to use xenogeneic (animal) ECM as the scaffold [ 20 ]. There has been research looking into use of porcine lungs; however, there are concerns of α-galactosyl epitope in the ECM potentially eliciting a rejection response.…”

Section: Bioengineered Lungs and Organ Repair Centers: Expanding Poss...mentioning

confidence: 99%

Epidemiology and Long-Term Outcomes in Thoracic Transplantation

Abraham,

Singh,

Abraham

et al. 2023

JCDD

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Over the past five decades, outcomes for lung transplantation have significantly improved in the early post-operative period, such that lung transplant is now the gold standard treatment for end-stage respiratory disease. The major limitation that impacts lung transplant survival rates is the development of chronic lung allograft dysfunction (CLAD). CLAD affects around 50% of lung transplant recipients within five years of transplantation. We must also consider other factors impacting the survival rate such as the surgical technique (single versus double lung transplant), along with donor and recipient characteristics. The future is promising, with more research looking into ex vivo lung perfusion (EVLP) and bioengineered lungs, with the hope of increasing the donor pool and decreasing the risk of graft rejection.

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Section: Bioengineered Lungs and Organ Repair Centers: Expanding Poss...mentioning

confidence: 99%

Epidemiology and Long-Term Outcomes in Thoracic Transplantation

Abraham,

Singh,

Abraham

et al. 2023

JCDD

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“…Given the lung is a complex organ with 40 different cell types that interact with the extracellular matrix, there are pros and cons regarding the use of a biological (porcine or human) decellularized scaffold versus a synthetic acellular lung scaffold. The ideal decellularization processes have also not yet been identified and challenges also arise in choosing the appropriate cell types, quantities, and combinations for recellularization [54]. Much work is still to be done in this field.…”

Section: Other Potential Novel Sources Of Donor Lungsmentioning

confidence: 99%

How do we expand the lung donor pool?

Levvey,

Snell

2024

Current Opinion in Pulmonary Medicine

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Purpose of review Lung transplantation activity continues to be limited by the availability of timely quality donor lungs. It is apparent though that progress has been made. The steady evolution of clinical practice, combined with painstaking scientific discovery and innovation are described. Recent findings There have been successful studies reporting innovations in the wider use and broader consideration of donation after circulatory death donor lungs, including an increasing number of transplants from each of the controlled, uncontrolled and medically assisted dying donor descriptive categories. Donors beyond age 70 years are providing better than expected long-term outcomes. Hepatitis C PCR positive donor lungs can be safely used if treated postoperatively with appropriate antivirals. Donor lung perfusion at a constant 10 degrees appears capable of significantly improving donor logistics and ex-vivo lung perfusion offers the potential of an ever-increasing number of novel donor management roles. Bioartificial and xenografts remain distant possibilities only at present. Summary Donor lungs have proved to be surprisingly robust and combined with clinical, scientific and engineering innovations, the realizable lung donor pool is proving to be larger than previously thought.

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“…In addition, 3D bioprinting has been widely used in artificial organ fabrication and tissue regeneration ( Ramadan and Zourob, 2020 ; Jain et al 2022 ; Panda et al 2022 ; Pourmasoumi et al 2022 ; Wang et al 2023 ). Moreover, owing to its unique advantages, 3D bioprinting plays a key role in the construction of common disease in vitro models and organoids ( Fan et al 2019 ; Guagliano et al 2022 ; Joddar et al 2022 ; Jubelin et al 2022 ; Neufeld et al 2022 ; Shakir et al 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Global hotspots and emerging trends in 3D bioprinting research

Ding

Tang

Huang

et al. 2023

Front. Bioeng. Biotechnol.

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Three-dimensional (3D) bioprinting is an advanced tissue engineering technique that has received a lot of interest in the past years. We aimed to highlight the characteristics of articles on 3D bioprinting, especially in terms of research hotspots and focus. Publications related to 3D bioprinting from 2007 to 2022 were acquired from the Web of Science Core Collection database. We have used VOSviewer, CiteSpace, and R-bibliometrix to perform various analyses on 3,327 published articles. The number of annual publications is increasing globally, a trend expected to continue. The United States and China were the most productive countries with the closest cooperation and the most research and development investment funds in this field. Harvard Medical School and Tsinghua University are the top-ranked institutions in the United States and China, respectively. Dr. Anthony Atala and Dr. Ali Khademhosseini, the most productive researchers in 3D bioprinting, may provide cooperation opportunities for interested researchers. Tissue Engineering Part A contributed the largest publication number, while Frontiers in Bioengineering and Biotechnology was the most attractive journal with the most potential. As for the keywords in 3D bioprinting, Bio-ink, Hydrogels (especially GelMA and Gelatin), Scaffold (especially decellularized extracellular matrix), extrusion-based bioprinting, tissue engineering, and in vitro models (organoids particularly) are research hotspots analyzed in the current study. Specifically, the research topics “new bio-ink investigation,” “modification of extrusion-based bioprinting for cell viability and vascularization,” “application of 3D bioprinting in organoids and in vitro model” and “research in personalized and regenerative medicine” were predicted to be hotspots for future research.

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Bioengineering lungs: An overview of current methods, requirements, and challenges for constructing scaffolds

Cited by 12 publications

References 85 publications

Epidemiology and Long-Term Outcomes in Thoracic Transplantation

Epidemiology and Long-Term Outcomes in Thoracic Transplantation

How do we expand the lung donor pool?

Global hotspots and emerging trends in 3D bioprinting research

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