1999
DOI: 10.1002/(sici)1097-4636(19990305)44:3<280::aid-jbm6>3.0.co;2-h
|View full text |Cite
|
Sign up to set email alerts
|

Bioengineering of elastic cartilage with aggregated porcine and human auricular chondrocytes and hydrogels containing alginate, collagen, and ?-elastin

Abstract: Transplantation of isolated chondrocytes has long been acknowledged as a potential method for rebuilding small defects in damaged or deformed cartilages. Recent advances in tissue engineering permit us to focus on production of larger amounts of cartilaginous tissue, such as might be needed for reconstructive surgery of the entire auricle. In this report we describe modification of the basic techniques that lead to production of a large amount of elastic cartilage originated from porcine and human isolated cho… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

1
34
0
1

Year Published

2005
2005
2024
2024

Publication Types

Select...
4
2
2

Relationship

0
8

Authors

Journals

citations
Cited by 73 publications
(36 citation statements)
references
References 50 publications
1
34
0
1
Order By: Relevance
“…Among the most commonly used hydrogels for constructing engineered tissue are natural polymers such as agarose, alginate, chitosan, collagen, fibrin and hyaluronic acid as well as synthetic polymers such as poly(acrylic acid) (PAA) and poly(vinyl alcohol) (PVA). Hydrogels are particularly useful as engineering scaffolds for soft viscoelastic tissues and have been used to replicate cartilage (de Chalain et al 1999), cornea (Minami et al 1993), skin (Eaglstein & Falanga 1997) and vascular tissue (Weinberg & Bell 1986). Among the common features of all these tissues are their high degree of flexibility and their ability to withstand forces.…”
Section: Introductionmentioning
confidence: 99%
“…Among the most commonly used hydrogels for constructing engineered tissue are natural polymers such as agarose, alginate, chitosan, collagen, fibrin and hyaluronic acid as well as synthetic polymers such as poly(acrylic acid) (PAA) and poly(vinyl alcohol) (PVA). Hydrogels are particularly useful as engineering scaffolds for soft viscoelastic tissues and have been used to replicate cartilage (de Chalain et al 1999), cornea (Minami et al 1993), skin (Eaglstein & Falanga 1997) and vascular tissue (Weinberg & Bell 1986). Among the common features of all these tissues are their high degree of flexibility and their ability to withstand forces.…”
Section: Introductionmentioning
confidence: 99%
“…In porous PCL scaffolds, infusion of -elastin demonstrates enhanced scaffold elasticity and attachment and proliferation of articular cartilage chondrocytes in vitro (Annabi, Fathi et al 2011). Replication of auricular-like cartilage has also been explored using alginate, collagen type I and κ-elastin containing hydrogels with auricular cartilage chondrocytes (de Chalain, Phillips et al 1999). When these materials were implanted in mice and harvested after 12 weeks, matrix components including collagen and elastic fibers were present.…”
Section: Hydrolyzed Elastin Materialsmentioning
confidence: 99%
“…This also has replaced old-fashioned methods such as costal cartilage grafting, which was mandating the timing of surgery to be delayed until the age of 6-10 [5], and carry the risk of pneumothorax and chest wall deformities [6].…”
mentioning
confidence: 99%