Bioequivalence of Generic Drugs

Andrade, Chittaranjan

doi:10.4088/jcp.15f10300

Cited by 19 publications

(18 citation statements)

References 6 publications

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“…Generic medications provide a lower cost option. However, even though approval of a generic medication requires a demonstration of bioequivalence, which does sometimes fail ( Chenu et al, 2009 ; Woodcock et al, 2012 ), there nonetheless may be efficacy or tolerability differences for some patients taking generic drugs, possibly related to difference in excipients ( Gallelli et al, 2013 ; Andrade, 2015 ). Discussing insurance coverage may inform antidepressant selection, as restrictions and higher copay requirements may preclude patients from following through with their prescription.…”

Section: How Does the Clinician Provide Early Optimized Treatment Formentioning

confidence: 99%

Functional Recovery in Major Depressive Disorder: Providing Early Optimal Treatment for the Individual Patient

Oluboka

Katzman

Habert

et al. 2017

International Journal of Neuropsychopharmacology

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Major depressive disorder is an often chronic and recurring illness. Left untreated, major depressive disorder may result in progressive alterations in brain morphometry and circuit function. Recent findings, however, suggest that pharmacotherapy may halt and possibly reverse those effects. These findings, together with evidence that a delay in treatment is associated with poorer clinical outcomes, underscore the urgency of rapidly treating depression to full recovery. Early optimized treatment, using measurement-based care and customizing treatment to the individual patient, may afford the best possible outcomes for each patient. The aim of this article is to present recommendations for using a patient-centered approach to rapidly provide optimal pharmacological treatment to patients with major depressive disorder. Offering major depressive disorder treatment determined by individual patient characteristics (e.g., predominant symptoms, medical history, comorbidities), patient preferences and expectations, and, critically, their own definition of wellness provides the best opportunity for full functional recovery.

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Section: How Does the Clinician Provide Early Optimized Treatment Formentioning

confidence: 99%

Functional Recovery in Major Depressive Disorder: Providing Early Optimal Treatment for the Individual Patient

Oluboka

Katzman

Habert

et al. 2017

International Journal of Neuropsychopharmacology

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“…There is evidence to suggest that generic medicines are as good as branded medicines with regard to bioequivalence and therapeutic equivalence. [10][11][12] Few prescriptions were irrational like gastritis, acute gastroentereitis, enteric fever, malaria, organophosphorus poisoning and bronchopneumonia. The irrational use of prescriptions will not only promote health problems can also be linked to adverse effects, high cost, drug interactions and emergence of drug resistance, especially in antimicrobial therapy.…”

Section: Resultsmentioning

confidence: 99%

Prescription audit of patients in a teritiary care hospital

Kodam

Tamma

Karedla

2020

Int J Basic Clin Pharmacol

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Background: This study was prescribed errors to promote irrational use of drug and decrease patience compliance. Prescription audit can improve prescribing practices and patients to receive high quality drugs.Methods: The study was observational carried out in 150 patients attending outpatient department for period of 6 months from April 2019 to October 2019. Data was analysed using WHO core indicatorsResults: 16% of prescriptions demographic details like age, sex, age were incomplete. In few (15%) prescriptions omission of diagnosis and irrational combination was reported. Dosing errors like doses and duration of treatment were not mentioned in some of prescriptions. Percentage of antibiotics per prescription was found to be 23.64%, which is much higher than the ideal value recommended by WHO.Conclusions: The average number of drugs was higher in prescriptions and trend of polypharmacy was noted with antibiotics usage. Dosing error and few prescriptions were irrational FDCs. Generic drugs were written in majority of prescriptions from essential drug list. Our study need to highlight to write rational prescription by adhering to WHO guidelines with feed back to prescribers and training session regarding safe use of drugs.

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“…This can create problem for drugs with narrow therapeutic index [26]. According to the Adrade [27], this is because bioequivalent brands of drugs may differ in their excipient content, which can result in variations in safety profiles. In our study, vast majority of the participants emphasized the therapeutic equivalence of the drug for their preferences.…”

Section: Discussionmentioning

confidence: 99%

Brand Loyalty as a Strategy for the Competition with Generic Drugs:Physicians Perspective

Macit¹,

Taner²,

Mercanoğlu³

et al. 2016

J Dev Drugs

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Like in other industries, the competition among companies in the pharma industry is high. Therefore, pharmaceutical companies have to design their strategies in order to achieve competitive advantage. Brand loyalty is a powerful tool in the development of pharmaceutical brands. Physicians play major role in the selection of drugs to consume and can also be considered as the consumer. This descriptive study examines the factors that influence physicians' choices of medication for their patients. Data was collected using a survey administered to specialists and trainees from Cardiology Department. Total 18 physicians participated in the study. Most of the respondents (85%) declared the scientific literature regarding the drug as their first priority in prescribing. Almost half of the respondents (46%) declared the published clinical trial results as a primary source of information about the launch of new drug. With respect to the inclusion of a newly launched drug in the daily prescribing routine, 85% of the respondents tended to prescribe a new drug after the publication of clinical trials. A vast majority of the participants indicated the patients' source of payment as a major factor for their preferences; meanwhile 92% of them also emphasized the therapeutic equivalency of the drug for their preferences. More than half of the participants (>70%) tended to prescribe original drugs to patients having chronic disease/comorbidity and special insurance coverage and/or self-payment. Regarding the physicians' familiarity to the original proprietary names, more than half of the respondents correctly predicted the original proprietary names. This study reflects the physician's perspective for the establishment of brand loyalty. From the physicians' standpoint belief in brand is crucial for the creation of brand loyalty and the key for building up trust is the scientific data regarding the effectiveness and safety of the drug obtained from large-scale clinical trials.

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Bioequivalence of Generic Drugs

Cited by 19 publications

References 6 publications

Functional Recovery in Major Depressive Disorder: Providing Early Optimal Treatment for the Individual Patient

Functional Recovery in Major Depressive Disorder: Providing Early Optimal Treatment for the Individual Patient

Prescription audit of patients in a teritiary care hospital

Brand Loyalty as a Strategy for the Competition with Generic Drugs:Physicians Perspective

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