Bioethics: a look at animal testing in medicine and cosmetics in the UK

Kabene, Stefane; Baadel, Said

doi:10.18502/jmehm.v12i15.1875

Cited by 25 publications

(21 citation statements)

References 17 publications

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“…The drug's extensive efficiency (EE) was calculated by the number of treated animals that were completely free from invasion in a percentage. Experiments with animals were performed according to current bioethical requirements (Festing & Wilkinson, 2007;Kabene & Baadel, 2019).…”

Section: Methodsmentioning

confidence: 99%

Effectiveness of a modern antiparasitic agent for deworming in domestic animals

Paliy¹,

Петров²,

Kovalenko³

et al. 2021

Ukr J Ecol

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Parasitic diseases continue to account for a significant proportion of overall morbidity in many parts of the world despite improved living conditions and increased awareness of health issues. The creation of innovative veterinary antiparasitic agents is a promising area of modern veterinary pharmacy. The pathogens Dipylidium caninum, Ancylostoma caninum, Toxocara canis, Toxocaris leonina were identified in the study of stray dogs (n=12). Eggs of Dipylidium caninum, Toxocara mystax, and Toxocaris leonina were found during cats' examination (n=15). Both mono and mixed invasions have been diagnosed in animals. We established that the floor and inventory were contaminated with exogenous forms of helminths at an extent of 100% after keeping animals in the shelter's enclosures. An innovative antiparasitic agent was used to treat animals. One tablet (0.5 g) contains the following active ingredients such as pyrantel pamoate (150±0.5 mg), praziquantel (50±0.5 mg), and auxiliary substances (lactose, microcrystalline cellulose, calcium stearate, sodium chloride, food flavoring "meat", povidone K-30 and potato starch). We estimated high antiparasitic agents' extensive efficiency (100%) at mono and mixed invasions in dogs and cats.

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Section: Methodsmentioning

confidence: 99%

Effectiveness of a modern antiparasitic agent for deworming in domestic animals

Paliy¹,

Петров²,

Kovalenko³

et al. 2021

Ukr J Ecol

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“…The research was conducted in the period from August to November 2018 and 2019 in the south of Ukraine (Odessa, Mykolaiv, Kherson regions). Animal experiments do not contradict the current legislation of Ukraine (Article 26 of the Law of Ukraine 5456-VI of 16.10.2012 "On protection of animals from cruel treatment") and "General ethical principles of animal experiments", adopted by the First National Congress on Bioethics (Kyiv, 2001) and international bioethical standards (materials of the IV European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Purposes, Strasbourg, 1985) (Festing & Wilkinson, 2007;Simmonds, 2017;Kabene & Baadel, 2019). The research program was reviewed and approved by the Bioethics Commission of National Scientific Center "Institute of Experimental and Clinical Veterinary Medicine" in the current order.…”

Section: Methodsmentioning

confidence: 99%

Parasites of domestic and wild pigeons in the south of Ukraine

et al. 2021

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Pigeons are closely related to human life and are both a source of food and object for hobbies and sports. Parasitic diseases of birds are the main reason for their growth retardation, reduced productivity and viability. The article presents the results of studying the prevalence of trichomonosis, cestodes and nematodes among the population of wild and domestic pigeons in the south of Ukraine. According to the results of the conducted researches it is established that in the south of Ukraine endoparasitoses of domestic and wild pigeons are quite widespread, and all species of this bird are carriers of Trichomonas gallinae. At the same time, the highest rate of Trichomonas infection was recorded in Columba palambus and C. livia domestica, and the overall infestation of males is higher by 4.4% compared to females. It was determined that domestic pigeons C. livia domestica were infested with trichomonosis (27.5%) and nematodes (Ascaridia columbae, 57.1%), C. palambus – trichomonosis (32.1%) and cestodes (Raillietina spp., 82.4%), Streptopelia turtur – cestodes (Raillietina spp., 12.5%) and S. decaocto – cestodes (Raillietina spp., 71.4%) and nematodes (Heterakis gallinarum, A. columbae – 33.3% and 44.4% respectively). The overall rate of infestation of pigeons with cestodes was 28.4% and the incidence in males was higher by 3.9% compared to females. It was found that the most common species among pigeon cestodes is Raillietina spp. In addition, 22.9% of pigeons are carriers of nematodes (H. gallinarum, A. columbae and Capillaria spp.). Continuous monitoring of pigeon parasites is necessary because they, in most cases, come into contact with other species of poultry and are a source of general invasion. In terms of further research, it would be promising to study the prevalence of helminthic infestation among wild migratory birds.

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“…A sterile isotonic sodium chloride solution was injected into animals from the control group (n = 3). Experiments on animals were carried out in accordance with modern bioethical requirements (Festing & Wilkinson, 2007;Kabene & Baadel, 2019).…”

Section: Methodsmentioning

confidence: 99%

Etiological factors in triggering non-specific allergic reactions to tuberculin in cattle

Завгородний

Pozmogova

Kalashnyk

et al. 2021

Regul. Mech. Biosyst.

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The article presents the results of allergic and bacteriological studies of cattle from a tuberculosis-free farm. The presence of cattle reacting to an allergen from atypical mycobacteria was established in three allergic simultaneous tests during 2019–2020. Based on the results obtained, the causative agent of tuberculosis and atypical mycobacteria were not isolated during the bacteriological examination of a biological material from animals slaughtered for diagnostic purposes (n = 17), as well as soil (n = 5) and straw (n = 3) samples. However, microorganisms of the genera Nocardia (n = 2), Rhodococcus (n = 10), and Actinomyces (n = 5) were isolated from the biomaterial according to the results of microscopy, culture and biochemical tests. These microorganisms were also isolated from the soil and straw samples. Short-term non-specific reactions in cattle to mycobacterial allergens were due to the persistence and circulation of the aforementioned microorganisms closely related to mycobacteria. It was determined that the genera Nocardia and Rhodococcus are sensitive to the 1.0%, 2.0%, 3.0% solutions of glutaraldehyde, formaldehyde and sodium hydroxide. Thus, it is necessary to take into account the epizootic situation as to the presence of nocardioform microorganisms in the herd during routine allergic studies, as well as in case of differentiation between specific reactions and paraallergic and pseudoallergic ones. It is necessary to carry out comprehensive systematic studies of livestock and feed quality assessment. For the purpose of disinfection, glutaraldehyde and formaldehyde at a concentration of 1.0% are effective in destroying microorganisms of the genera Nocardia and Rhodococcus with 3-hour exposure or more.

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Bioethics: a look at animal testing in medicine and cosmetics in the UK

Cited by 25 publications

References 17 publications

Effectiveness of a modern antiparasitic agent for deworming in domestic animals

Effectiveness of a modern antiparasitic agent for deworming in domestic animals

Parasites of domestic and wild pigeons in the south of Ukraine

Etiological factors in triggering non-specific allergic reactions to tuberculin in cattle

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