Biofabricated green synthesized hibiscus silver nanoparticles potentiates antibacterial and cytotoxicity in human lung cancer cells

Abstract

Traditional medicine has long employed the shrub Hibiscus sabdariffa to treat a variety of illnesses. The biochemical characteristics of nanoparticles of silver made using the plant extract and plant extracts of Hibiscus sabdariffa were examined in this work. According to the results, the plant extract of Hibiscus sabdariffa had a total phenolic quantity of 84.9 mg/gm and a total quantity of flavonoids of 41.50 mg/gm. The extract also showed antibacterial action against Escherichia coli and Staphylococcus aureus (75.15% scavenging activity). The nanoparticles of silver from plant extracts were stable in PBS solution for at least 30 days and had a mean size of particles of 21.22 nm. Human cancer of the lung line of cells A-549 was effectively cytotoxic and anti-inflammatory by the silver nanoparticles. Overall, the research's findings demonstrate the fascinating biological activity of the nanoparticles of silver made from the extract of the Hibiscus sabdariffa plant. To assess these compounds' potential as medicines, more research is required.

Sustainable Synthesis of Novel Green-Based Nanoparticles for Therapeutic Interventions and Environmental Remediation

“…57 Other than this, green synthesis of AgNPs using Hibiscus sabdariffa has also shown an anticancer effect against lung cancer. 58 This flower was also used to synthesize Au/ZnO NPs that demonstrated significant anticancer activity against the MCF-7 human breast cancer cell line. 59 Similarly, the leaf extract of Melia azedarach was used to synthesize a polyethylene glycol (PEG) and chitosan fabricated and folate conjugated CuONP for in vitro targeting of cervical cancer.…”