Biofabrication of a novel biomolecule-assisted reduced graphene oxide: an excellent biocompatible nanomaterial

Zhang, Xifeng; Gurunathan, Sangiliyandi

doi:10.2147/ijn.s121847

Cited by 26 publications

(24 citation statements)

References 85 publications

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“…34,35,40 The results from this studies were corroborated with earlier reports on synthesis using various biomolecules such as tryptophan, plant extract, and pepsin. 34,35,40,45 The morphologies and structures of rGO-Ag nanocomposites observed using TEM revealed rGO sheets with wrinkles and folds. The SEM and TEM images clearly showed that a large number of AgNPs were deposited onto GO, which may be ascribed to the strong interaction between lycopene and rGO via physical absorption in the form of hydrogen bonding and other molecular interactions.…”

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confidence: 89%

“…34,40,41 In a typical synthesis process, 2 g natural Gt powder was added to 350 mL H 2 SO 4 at 0°C; 8 g KMnO 4 and 1 g NaNO 3 were added gradually while stirring. The mixture was transferred to a 40°C water bath and stirred for 60 min.…”

Section: Materials and Methods Materialsmentioning

confidence: 99%

“…The D band was assigned to the breathing mode of the k-point phonons with A 1g symmetry, whereas the G band introduced the E 2g phonon of the carbon sp 2 atoms. 34,35,40 As shown in Figure 6, Counts (au) Figure 6 raman spectroscopy analyses of gO, rgO, agNPs, and rgO-ag nanocomposites. Notes: raman spectra of gO, rgO, agNPs, and rgO-ag nanocomposites were obtained using a laser excitation wavelength of 532 nm at the power of 1 mW, after the removal of background fluorescence.…”

mentioning

confidence: 95%

“…As shown in Figure 4, GO samples showed thick and multiple layers of aggregated and squareshaped crumpled sheets closely associated with each other forming a continuous conducting network. 34,35,40 The typical GO samples showed characteristic features of crumpled, folded, and closely restacked sheets, and the surface of GO exhibited a soft carpet-like morphology, possibly because of the presence of residual H 2 O molecules and hydroxyl or carboxyl groups. 34,35,40 rGO exhibited transparent rippled silk-like waves, or a flaky, scale-like, layered structure.…”

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confidence: 99%

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Novel biomolecule lycopene-reduced graphene oxide-silver nanoparticle enhances apoptotic potential of trichostatin A in human ovarian cancer cells (SKOV3)

Zhang¹,

Huang²,

Zhang³

et al. 2017

IJN

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Background Recently, there has been much interest in the field of nanomedicine to improve prevention, diagnosis, and treatment. Combination therapy seems to be most effective when two different molecules that work by different mechanisms are combined at low dose, thereby decreasing the possibility of drug resistance and occurrence of unbearable side effects. Based on this consideration, the study was designed to investigate the combination effect of reduced graphene oxide-silver nanoparticles (rGO-AgNPs) and trichostatin A (TSA) in human ovarian cancer cells (SKOV3). Methods The rGO-AgNPs were synthesized using a biomolecule called lycopene, and the resultant product was characterized by various analytical techniques. The combination effect of rGO-Ag and TSA was investigated in SKOV3 cells using various cellular assays such as cell viability, cytotoxicity, and immunofluorescence analysis. Results AgNPs were uniformly distributed on the surface of graphene sheet with an average size between 10 and 50 nm. rGO-Ag and TSA were found to inhibit cell viability in a dose-dependent manner. The combination of rGO-Ag and TSA at low concentration showed a significant effect on cell viability, and increased cytotoxicity by increasing the level of malondialdehyde and decreasing the level of glutathione, and also causing mitochondrial dysfunction. Furthermore, the combination of rGO-Ag and TSA had a more pronounced effect on DNA fragmentation and double-strand breaks, and eventually induced apoptosis. Conclusion This study is the first to report that the combination of rGO-Ag and TSA can cause potential cytotoxicity and also induce significantly greater cell death compared to either rGO-Ag alone or TSA alone in SKOV3 cells by various mechanisms including reactive oxygen species generation, mitochondrial dysfunction, and DNA damage. Therefore, this combination chemotherapy could be possibly used in advanced cancers that are not suitable for radiation therapy or surgical treatment and facilitate overcoming tumor resistance and disease progression.

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confidence: 89%

Section: Materials and Methods Materialsmentioning

confidence: 99%

mentioning

confidence: 95%

mentioning

confidence: 99%

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Novel biomolecule lycopene-reduced graphene oxide-silver nanoparticle enhances apoptotic potential of trichostatin A in human ovarian cancer cells (SKOV3)

Zhang¹,

Huang²,

Zhang³

et al. 2017

IJN

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“…Graphene nanoparticles with oxidized form (nanographene oxides [NGOs]) have higher hydrophilicity than NGO, and are sufficiently beneficial to become a drug-delivery system in vivo. [3][4][5][6][7] NGO has been reported as a metal-complex nanoplatform. [8][9][10][11] Conjugation of cancertargeted ligands on the surface of a nanosystem is an effective strategy to enhance tumor selectivity by active targeting.…”

Section: Introductionmentioning

confidence: 99%

Transferrin-functionalized nanographene oxide for delivery of platinum complexes to enhance cancer-cell selectivity and apoptosis-inducing efficacy

Zhu¹,

Zhou²,

Chan³

et al. 2017

IJN

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Rational design and construction of delivery nanosystems for anticancer metal complexes is a crucial strategy to improve solubility under physiological conditions and permeability and retention behavior in tumor cells. Therefore, in this study, we designed and synthesize a transferrin (Tf)-conjugated nanographene oxide (NGO) nanosystem as a cancer-targeted nanocarrier of Pt complexes (Tf-NGO@Pt). This nanodelivery system exhibited good solubility under physiological conditions. Moreover, Tf-NGO@Pt showed higher anticancer efficacy against MCF human breast cancer cells than the free Pt complex, and effectively inhibited cancer-cell migration and invasion, with involvement of reactive oxygen species overproduction. In addition, nanolization also enhanced the penetration ability and inhibitory effect of the Pt complex toward MCF7 breast cancer-cell tumor spheroids. The enhancement of anticancer efficacy was positively correlated with increased cellular uptake and cellular drug retention. This study provides a new strategy to facilitate the future application of metal complexes in cancer therapy.

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Nanomaterials and nanocomposite applications in veterinary medicine

Hassan

Mansour²,

Hamaky

et al. 2020

Multifunctional Hybrid Nanomaterials for Sustainable Agri-Food and Ecosystems

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Biofabrication of a novel biomolecule-assisted reduced graphene oxide: an excellent biocompatible nanomaterial

Cited by 26 publications

References 85 publications

Novel biomolecule lycopene-reduced graphene oxide-silver nanoparticle enhances apoptotic potential of trichostatin A in human ovarian cancer cells (SKOV3)

Novel biomolecule lycopene-reduced graphene oxide-silver nanoparticle enhances apoptotic potential of trichostatin A in human ovarian cancer cells (SKOV3)

Transferrin-functionalized nanographene oxide for delivery of platinum complexes to enhance cancer-cell selectivity and apoptosis-inducing efficacy

Nanomaterials and nanocomposite applications in veterinary medicine

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