Biofabrication of nanoparticles: sources, synthesis, and biomedical applications

Kulkarni, Deepak; Sherkar, Rushikesh; Shirsathe, Chaitali; Sonwane, Rushikesh; Varpe, Nikita; Shelke, Santosh; More, Mahesh P.; Pardeshi, Sagar R.; Dhaneshwar, Gargee; Junnuthula, Vijayabhaskarreddy; Dyawanapelly, Sathish

doi:10.3389/fbioe.2023.1159193

Cited by 53 publications

(15 citation statements)

References 216 publications

(232 reference statements)

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“…Many bioactive substances found in fresh leaves and seeds, including phenolics, terpenoids, and flavonoids, function as capping and reducing agents to help turn silver ions into nanoparticles (Hasan et al 2022 ). In a similar vein, biomolecules and enzymes generated by bacterial and fungal metabolites accelerate the reduction of silver ions, which results in the creation of AgNPs (Kulkarni et al 2023 ). These biological sources have various benefits, such as reduced environmental impact, cost-effectiveness, and scalability.…”

Section: Nanoparticles Approachesmentioning

confidence: 99%

Unraveling the mysteries of silver nanoparticles: synthesis, characterization, antimicrobial effects and uptake translocation in plant—a review

Fares,

Mahdy,

Ahmed

2024

Planta

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Main conclusion The study thoroughly investigates nanosilver production, properties, and interactions, shedding light on its multifaceted applications. It underscores the importance of characterizing nanosilver for predicting its behavior in complex environments. Particularly, it highlights the agricultural and environmental ramifications of nanosilver uptake by plants. Abstract Nowadays, silver nanoparticles (AgNPs) are a very adaptable nanomaterial with many uses, particularly in antibacterial treatments and agricultural operations. Clarification of key elements of nanosilver, such as its synthesis and characterization procedures, antibacterial activity, and intricate interactions with plants, particularly those pertaining to uptake and translocation mechanisms, is the aim of this in-depth investigation. Nanosilver synthesis is a multifaceted process that includes a range of methodologies, including chemical, biological, and sustainable approaches that are also environmentally benign. This section provides a critical evaluation of these methods, considering their impacts on repeatability, scalability, and environmental impact. The physicochemical properties of nanosilver were determined by means of characterization procedures. This review highlights the significance of analytical approaches such as spectroscopy, microscopy, and other state-of the-art methods for fully characterizing nanosilver particles. Although grasp of these properties is necessary in order to predict the behavior and potential impacts of nanosilver in complex biological and environmental systems. The second half of this article delves into the intricate interactions that plants have with nanosilver, emphasizing the mechanisms of absorption and translocation. There are significant ramifications for agricultural and environmental problems from the uptake of nanosilver by plants and its subsequent passage through their tissues. In summary, by summarizing the state-of-the-art information in this field, this study offers a comprehensive overview of the production, characterization, antibacterial capabilities, and interactions of nanosilver with plants. This paper contributes to the ongoing conversation in nanotechnology. Graphical abstract

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Section: Nanoparticles Approachesmentioning

confidence: 99%

Unraveling the mysteries of silver nanoparticles: synthesis, characterization, antimicrobial effects and uptake translocation in plant—a review

Fares,

Mahdy,

Ahmed

2024

Planta

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“…The biocompatibility of AgNPs synthesized using plant extracts makes them well-suited for medical and biological applications. These nanoparticles can be used in drug delivery systems, wound healing, tissue engineering, and as antimicrobial agents without adverse effects on living organisms [ 62 , 63 ].…”

Section: Introductionmentioning

confidence: 99%

Rosmarinic Acid-Rich Perilla frutescens Extract-Derived Silver Nanoparticles: A Green Synthesis Approach for Multifunctional Biomedical Applications including Antibacterial, Antioxidant, and Anticancer Activities

Netala,

Hou,

Sana

et al. 2024

Molecules

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This study describes a simple, cost-effective, and eco-friendly method for synthesizing silver nanoparticles using a rosmarinic acid extract from Perilla frutescens (PFRAE) as the bioreduction agent. The resulting nanoparticles, called PFRAE-AgNPs, were characterized using various analytical techniques. The UV–Vis spectrum confirmed the formation of PFRAE-AgNPs, and the FTIR spectrum indicated the participation of rosmarinic acid in their synthesis and stabilization. The XRD pattern revealed the crystal structure of PFRAE-AgNPs, and the TEM analysis showed their spherical morphology with sizes ranging between 20 and 80 nm. The DLS analysis indicated that PFRAE-AgNPs were monodispersed with an average diameter of 44.0 ± 3.2 nm, and the high negative zeta potential (−19.65 mV) indicated their high stability. In the antibacterial assays, the PFRAE-AgNPs showed potent activity against both Gram-positive (Bacillus subtilis and Staphylococcus aureus) and Gram-negative (Escherichia coli and Pseudomonas aeruginosa) bacterial pathogens, suggesting that they could be used as a potential antibacterial agent in the clinical setting. Moreover, the antioxidant activity of PFRAE-AgNPs against DPPH and ABTS radical scavengers highlights their potential in the treatment of various oxidative stress-related diseases. PFRAE-AgNPs also demonstrated significant anticancer activity against a range of cell lines including human colon cancer (COLO205), human prostate carcinoma (PC-3), human lung adenocarcinoma (A549), and human ovarian cancer (SKOV3) cell lines suggesting their potential in cancer therapy. The nanoparticles may also have potential in drug delivery, as their small size and high stability could enable them to cross biological barriers and deliver drugs to specific target sites. In addition to the aforementioned properties, PFRAE-AgNPs were found to be biocompatible towards normal (CHO) cells, which is a crucial characteristic for their application in cancer therapy and drug delivery systems. Their antibacterial, antioxidant, and anticancer properties make them promising candidates for the development of new therapeutic agents. Furthermore, their small size, high stability, and biocompatibility could enable them to be used in drug delivery systems to enhance drug efficacy and reduce side effects.

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“…In this process, the plant extract is combined with metal precursors and the metal ions undergo specific steps (reduction, nucleation, growth and stabilization). This plant-based synthesis approach is eco-friendly, cost-effective, simple, and potentially scalable for industrial production ( Kulkarni et al, 2023 ; Radulescu et al, 2023 ). However, it is challenging to precisely control particle size, morphology, and crystallinity.…”

Section: Introductionmentioning

confidence: 99%

Exploring the potential of a Ephedra alata leaf extract: Phytochemical analysis, antioxidant activity, antibacterial properties, and green synthesis of ZnO nanoparticles for photocatalytic degradation of methylene blue

Zaater,

Serhoud,

Ben Amor

et al. 2024

Front. Chem.

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Ephedra alata leaf extracts have therapeutic properties and contain various natural compounds known as phytochemicals. This study assessed the phytochemical content and antioxidant effects of a Ephedra alata leaf extract, as well as zinc oxide (ZnO) nanoparticle production. The extract contained phenolic acids, including vanillic acid, chlorogenic acid, gallic acid, p-coumaric acid, vanillin and rutin. Its total phenolic content and total flavonoid content were 48.7 ± 0.9 mg.g-1 and 1.7 ± 0.4 mg.g-1, respectively. The extract displayed a DPPH inhibition rate of 70.5%, total antioxidant activity of 49.5 ± 3.4 mg.g-1, and significant antimicrobial activity toward Gram-positive and negative bacteria. The synthesized ZnO nanoparticles had spherical shape, crystallite size of 25 nm, particle size between 5 and 30 nm, and bandgap energy of 3.3 eV. In specific conditions (90 min contact time, pH 7, and 25°C), these nanoparticles efficiently photodegraded 87% of methylene blue, suggesting potential applications for sustainable water treatment and pollution control.

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Biofabrication of nanoparticles: sources, synthesis, and biomedical applications

Abstract: Graphical AbstractSources for biogenic synthesis: The synthesis sources include but are not limited to bacteria, fungi, algae, yeasts, marine and plant sources.

Cited by 53 publications

References 216 publications

Unraveling the mysteries of silver nanoparticles: synthesis, characterization, antimicrobial effects and uptake translocation in plant—a review

Unraveling the mysteries of silver nanoparticles: synthesis, characterization, antimicrobial effects and uptake translocation in plant—a review

Rosmarinic Acid-Rich Perilla frutescens Extract-Derived Silver Nanoparticles: A Green Synthesis Approach for Multifunctional Biomedical Applications including Antibacterial, Antioxidant, and Anticancer Activities

Exploring the potential of a Ephedra alata leaf extract: Phytochemical analysis, antioxidant activity, antibacterial properties, and green synthesis of ZnO nanoparticles for photocatalytic degradation of methylene blue

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