Biofabrication of size-controlled ZnO nanoparticles using various capping agents and their cytotoxic and antitermite activity

Din, Muhammad Imran; Rani, Aneela; Hussain, Zaib; Khalid, Ruhi; Aihetasham, Ayesha; Mukhtar, Maria

doi:10.1080/03067319.2019.1672671

Cited by 17 publications

(8 citation statements)

References 39 publications

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“…Different parts of plants, including the leaf, stem, root, fruit, bark, flowers, rhizomes, callus, seed, bud, and latex, have been extensively utilized in the green synthesis of nanoparticles due to the presence of various biomolecules. The plant-based bioconstituents like steroids, sapogenins, tannins, terpenoids, polyols, alkaloids, polysaccharides, flavonoids, phenolics, proteins, amino acids, enzymes, and vitamins (Figures 3 and 4) function as strong chelating, reducing, and stabilizing agents, which provide stability, prevent agglomeration, and help in tuning the shape and size of the nanoparticles (Adelere and Lateef, 2016;Nayak et al, 2020;Din et al, 2021;Jadoun et al, 2021;Restrepo and villa, 2021;Sivakumar, 2021;Tadele et al, 2021). A research study carried out by Shaheen and Ahmad (2020) identified the different biogenic capping agents [phenols (ascorbic acid, resorcinol, 4-nitrophenol, umbelliferone, vanillic acid, tannic acid, phenol, rutin, and ellagic acid), flavonoids, alkaloids, acetic acid, D-alanine, and aromatic and aliphatic amines (octodrine)] by HPLC and GC-MS from the leaves of Nasturtium officinale for the synthesis of Mo 3 nanoparticles.…”

Section: Plant Extract As a Capping Agentmentioning

confidence: 99%

Role of Biogenic Capping Agents in the Synthesis of Metallic Nanoparticles and Evaluation of Their Therapeutic Potential

Sidhu

Verma

Kaushal

2022

Front. Nanotechnol.

161

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The biomedical properties of nanoparticles have been the area of focus for contemporary science; however, there are issues concerning their long-term toxicities. Recent trends in nanoparticle fabrication and surface manipulation, the use of distinctive biogenic capping agents, have allowed the preparation of nontoxic, surface-functionalized, and monodispersed nanoparticles for medical applications. These capping agents act as stabilizers or binding molecules that prevent agglomeration and steric hindrance, alter the biological activity and surface chemistry, and stabilize the interaction of nanoparticles within the preparation medium. Explicit features of nanoparticles are majorly ascribed to the capping present on their surface. The present review article is an attempt to compile distinctive biological capping agents deployed in the synthesis of metal nanoparticles along with the medical applications of these capped nanoparticles. First, this innovative review highlights the various biogenic capping agents, including biomolecules and biological extracts of plants and microorganisms. Next, the therapeutic applications of capped nanoparticles and the effect of biomolecules on the efficiency of the nanoparticles have been expounded. Finally, challenges and future directions on the use of biological capping agents have been concluded. The goal of the present review article is to provide a comprehensive report to researchers who are looking for alternative biological capping agents for the green synthesis of important metallic nanoparticles.

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Section: Plant Extract As a Capping Agentmentioning

confidence: 99%

Role of Biogenic Capping Agents in the Synthesis of Metallic Nanoparticles and Evaluation of Their Therapeutic Potential

Sidhu

Verma

Kaushal

2022

Front. Nanotechnol.

161

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“…In general, capping agents, when used in synthesis, act as stabilisers through steric hindrance that counteract the agglomeration of NPs (thereby enhancing their dispersibility and shelflife in final drug formulations), modify the biological activity and surface chemistry and alter the interaction of NPs inside the preparation medium. [63][64][65] In addition, capping agents sometimes augment the reduction kinetics of NPs by forming complex structures with the metallic ions in the precursor salts. [66] The plant-based bio constituents like terpenoids, polyols, alkaloids, polysaccharides, flavonoids, phenolics, proteins, amino acids, enzymes, etc., are reported to serve as strong chelating, reducing, and stabilising agents while playing an important role in tuning the shape and size of the NPs.…”

Section: Size and Morphological Analysesmentioning

confidence: 99%

One‐Step Synthesis of Metal Oxide Nanoparticles Using Cannabidiol: Characterisation and Cytotoxicity Assessment in Human Keratinocyte Cells

Josiah,

Pillai,

Cordier

et al. 2024

ChemistrySelect

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This research paper explores the field of nanobiotechnology, focusing on the design, characterisation, and potential dermal applications of metal oxide nanoparticles (MONPs). ZnO and FeO NPs exhibit distinctive properties that are valuable in dermato‐cosmetic applications and transdermal drug delivery. This study investigates Cannabidiol (CBD) as a capping agent for MONPs synthesis. Employing microwave‐assisted techniques, MONPs were synthesised using either CBD or polyvinylpyrrolidone (PVP) as capping agents. The TEM, SEM, FTIR, and XRD characterisation results confirmed the successful formation of CBD‐capped ZnO and FeO NPs exhibiting an average particle size of 90 and 76 nm, respectively. The cytotoxicity of CBD‐capped MONPs was evaluated on HaCaT cells over a concentration range of 100 to 6.25 μg/mL, which revealed that CBD‐capped ZnO NPs exerted a cytotoxic effect on HaCaT cells (IC50 85.34±1.17 μg/mL). In contrast, CBD‐capped FeO NPs and PVP‐capped MONPs exhibited negligible cytotoxicity (IC50 >100 μg/mL). TEM analysis revealed a noticeable structural alteration of ZnO NPs in the supplemented cell culture medium, which could contribute to enhanced NP uptake, thereby explaining the more pronounced cytotoxic effect of ZnO NPs. Therefore, the disparity in cytotoxic responses can be attributed to the protein coating adhering to the NPs surface in a biological medium.

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“…Because metal ions contain important antibacterial properties due to their large surface area. Thus, they attract the attention of researchers due to the increased microbial resistance against antibiotics and the development of these resistant strains [3,4]. Nano metals have attracted great interest in branches such as physics, technology, chemistry, and bioengineering.…”

Section: Introductionmentioning

confidence: 99%

Peumus Boldus Koch Özütü Kullanılarak Nikel Nanopartiküllerin Yeşil Sentezi ve Antibakteriyel Aktivitesi

Taş

Köroğlu

Çelebioğlu

2021

International Journal of Innovative Engineering Applications

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Original scientific paperToday, nano-systems, especially multi-functional inorganic nanoparticles, attract a lot of attention in the biomedical field. Nickel nanoparticles, known as inorganic nanoparticles in nanotechnology and known as metallic nanoparticles with an important place, show antibacterial properties. The fact that nickel nanoparticles find use in areas requiring human contact leads to nanoparticle synthesis with biological systems. Thus, more environmentally friendly structures emerge. In this study, nickel nanoparticles were synthesized for the first time by biosynthesis using Peumus boldus extract. Structural, chemical, and morphological properties were examined by UV-vis spectrophotometer (UV-vis), fourier transform infrared spectroscopy (FTIR), X-ray diffractometer (XRD), and scanning electron microscopy (SEM) methods. Extract obtained from Peumus boldus was used as reducing agent in the synthesis of nickel nanoparticles. In addition, the antibacterial activities of the obtained nickel nanoparticles were investigated against E. coli and S. aureus.

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Biofabrication of size-controlled ZnO nanoparticles using various capping agents and their cytotoxic and antitermite activity

Cited by 17 publications

References 39 publications

Role of Biogenic Capping Agents in the Synthesis of Metallic Nanoparticles and Evaluation of Their Therapeutic Potential

Role of Biogenic Capping Agents in the Synthesis of Metallic Nanoparticles and Evaluation of Their Therapeutic Potential

One‐Step Synthesis of Metal Oxide Nanoparticles Using Cannabidiol: Characterisation and Cytotoxicity Assessment in Human Keratinocyte Cells

Peumus Boldus Koch Özütü Kullanılarak Nikel Nanopartiküllerin Yeşil Sentezi ve Antibakteriyel Aktivitesi

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