Biofabrication of Vascular Networks

Hoying, James B.; Williams, Stuart K.

doi:10.1016/b978-0-12-800972-7.00019-0

Cited by 3 publications

(4 citation statements)

References 118 publications

(149 reference statements)

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“…21 This is achieved by separating the polymer chains and thus allowing easier relative motion. 19 The addition of VD3 to PDLLA, a noteworthy stiff and brittle material with low deformation at break, 5,55 effectively reduced its modulus, although to a limited extent.…”

Section: Discussionmentioning

confidence: 99%

“…3,4 An example of widely used synthetic polymers is poly (lactide) (PLA), which has found application in orthopedic implants and scaffolds for bone regeneration, thanks to its high elastic modulus (1.5-2.7 GPa). 5 High M w grades, that is, well above the entanglement M w , are favored because of their higher mechanical properties in the solid state. 6 However, scaffold fibers have diameters in the order of a few hundreds of micrometers and this translates into making the polymer melt flow through very narrow channels.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cholecalciferol as Bioactive Plasticizer of High Molecular Weight Poly(D,L-Lactic Acid) Scaffolds for Bone Regeneration

Calore

Hadavi

Honing

et al. 2022

Tissue Engineering Part C: Methods

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show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cholecalciferol as Bioactive Plasticizer of High Molecular Weight Poly(D,L-Lactic Acid) Scaffolds for Bone Regeneration

Calore

Hadavi

Honing

et al. 2022

Tissue Engineering Part C: Methods

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“…The other way of engineering a pre-vasculature using bioprinting is by direct-writing, where cells are continuously administered as vascular cell suspensions inside an appropriate matrix. Thus, using this type of bioprinting, a vasculature more similar to the one to be replaced/needed can be obtained (Hoying and Williams, 2015). The potential of bioprinting was demonstrated in a study by Norotte et al (Norotte et al, 2009).…”

Section: Bioprintingmentioning

confidence: 98%

αvβ3 and α5β1 integrin-specific ligands: From tumor angiogenesis inhibitors to vascularization promoters in regenerative medicine?

Rocha

Learmonth

Sousa

et al. 2018

Biotechnology Advances

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Integrins are cell adhesion receptors predominantly important during normal and tumor angiogenesis. A sequence present on several extracellular matrix proteins composed of Arg-Gly-Asp (RGD) has attracted attention due to its role in cell adhesion mediated by integrins. The development of ligands that can bind to integrins involved in tumor angiogenesis and brake disease progression has resulted in new investigational drug entities reaching the clinical trial phase in humans. The use of integrin-specific ligands can be useful for the vascularization of regenerative medicine constructs, which remains a major limitation for translation into clinical practice. In order to enhance vascularization, immobilization of integrin-specific RGD peptidomimetics within constructs is a recommended approach, due to their high specificity and selectivity towards certain desired integrins. This review endeavours to address the potential of peptidomimetic-coated biomaterials as vascular network promoters for regenerative medicine purposes. Clinical studies involving molecules tracking active integrins in cancer angiogenesis and reasons for their failure are also addressed.

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“…For example, each vessel could have ca. three bifurcations, with a segmentation diameter ratio of ~1.3–1.6 and a length ratio of ~1.8–2.1 [ 27 ]. A more systematic description of branched vasculatures is Murray’s law, inspired by which Wu et al have made a vascular network with a direct writing technique [ 20 ].…”

Section: Am-based Vascular Constructsmentioning

confidence: 99%

Additive Manufacturing of Biomedical Constructs with Biomimetic Structural Organizations

Zhang

et al. 2016

Materials

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Additive manufacturing (AM), sometimes called three-dimensional (3D) printing, has attracted a lot of research interest and is presenting unprecedented opportunities in biomedical fields, because this technology enables the fabrication of biomedical constructs with great freedom and in high precision. An important strategy in AM of biomedical constructs is to mimic the structural organizations of natural biological organisms. This can be done by directly depositing cells and biomaterials, depositing biomaterial structures before seeding cells, or fabricating molds before casting biomaterials and cells. This review organizes the research advances of AM-based biomimetic biomedical constructs into three major directions: 3D constructs that mimic tubular and branched networks of vasculatures; 3D constructs that contains gradient interfaces between different tissues; and 3D constructs that have different cells positioned to create multicellular systems. Other recent advances are also highlighted, regarding the applications of AM for organs-on-chips, AM-based micro/nanostructures, and functional nanomaterials. Under this theme, multiple aspects of AM including imaging/characterization, material selection, design, and printing techniques are discussed. The outlook at the end of this review points out several possible research directions for the future.

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Biofabrication of Vascular Networks

Cited by 3 publications

References 118 publications

Cholecalciferol as Bioactive Plasticizer of High Molecular Weight Poly(D,L-Lactic Acid) Scaffolds for Bone Regeneration

Cholecalciferol as Bioactive Plasticizer of High Molecular Weight Poly(D,L-Lactic Acid) Scaffolds for Bone Regeneration

αvβ3 and α5β1 integrin-specific ligands: From tumor angiogenesis inhibitors to vascularization promoters in regenerative medicine?

Additive Manufacturing of Biomedical Constructs with Biomimetic Structural Organizations

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