Biofabrication of Zinc Oxide Nanoparticles from Aspergillus niger, Their Antioxidant, Antimicrobial and Anticancer Activity

Gao, Yu; Anand, Mariadoss Arokia Vijaya; Vinayagam, Ramachandran; Venkatachalam, Karthikkumar; Shalini, V.; Vijayalakshmi, S.; Ernest, David

doi:10.1007/s10876-019-01551-6

Cited by 86 publications

(36 citation statements)

References 35 publications

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“…FTIR spectra of the ATCF and the synthesized ZnONPs showed main bands of asymmetric and symmetric vibrations of C‐O and C = O bonds in COO ‐ groups, C‐H in CH 2 and in the phenyl ring, bands of phenols and primary amines, bands of O‐H in water, which were in a good agreement with literature (Kundu et al ; Gao et al ). However, the recorded spectrum of the synthesized ZnONPs showed the formation of new absorption band at 618 cm −1 .…”

Section: Discussionsupporting

confidence: 89%

“…Spectrum of the synthesized ZnONPs further showed the presence of COO ‐ groups and OH groups which could be attributed to the conjugation of ZnONPs with function groups of the ATCF used in the preparation process. In accordance with these results, Gao et al () observed the presence of the same bands corresponding to COO ‐ groups and OH groups in the spectrum of ZnONPs synthesized by the cell‐free filtrate of A. niger . The authors further attributed these observations to the conjugation of ZnONPs with functional groups of the fungal culture.…”

Section: Discussionsupporting

confidence: 62%

“…For example, Sarkar et al () used Alternaria alternate for the synthesis of ZnONPs with spherical, triangular, hexagonal shapes and the particle size distribution range was 45−150 nm. Gao et al () reported that the particle size of ZnONPs synthesized by A. niger ranged from 80 to 130 nm and it were almost rod and cluster in shape.…”

Section: Discussionmentioning

confidence: 99%

“…Secondly, the synthesized ZnONPs were capped by these metabolites thereby stabilizing them. In literature, several reports concluded that extracellular synthesis of ZnONPs is a nitrate reductase‐mediated synthesis, which is responsible for the reduction of Zn ions into ZnONPs (Kundu et al ; Chauhan et al ; Kalpana et al ; Gao et al ). The reduction of Zn ions starts through electron transfer from NADH by NADH‐dependent reductase that acts as an electron carrier (Hulkoti and Taranath ).…”

Section: Discussionmentioning

confidence: 99%

“…ZnONPs had high absorption rate, lower toxicity (Yusof et al ), better bioavailability and biocompatibility compared to their conventional Zn sources (Hosseini and Sarviab ; Shahid et al ). They showed a wide range of biological and therapeutic activities including antibacterial (Shahid et al ; Abd Elkodous et al ), antioxidant (Gao et al ), antiprotozoa (Wajiha et al ) and anticancer (Bisht and Rayamajhi ). In addition, recent studies indicated the promising properties of ZnONPs that could be implemented in the poultry and livestock industry (Zhao et al ; Khoobbakht et al ).…”

Section: Introductionmentioning

confidence: 99%

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Biosynthesis of zinc oxide nanoparticles with antimicrobial, anticancer, antioxidant and photocatalytic activities by the endophytic Alternaria tenuissima

2020

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Aims Zinc oxide nanoparticles (ZnONPs) were successfully synthesized using the culture filtrate of the endophytic fungus Alternaria tenuissima as a rapid, eco‐friendly and cost‐effective method. Methods and Results The rapid synthesis of ZnONPs was completed after 20 min as confirmed by UV–Vis spectroscopy. The synthesized ZnONPs showed a single‐phase crystalline structure. Dynamic light scattering analysis showed that the synthesized ZnONPs were monodispersed and the recorded polydispersity index value was 0·311. Zeta potential value of –23·92 mV indicated the high stability of ZnONPs. Transmission electron microscope revealed the spherical shape and the mean particle size was 15.45 nm. Functional groups present in the prepared samples of ZnONPs were confirmed by Fourier transform infrared spectroscopy. Additionally, the biological activities of in vitro antimicrobial, anticancer, antioxidant as well as the photocatalytic activities were evaluated. ZnONPs showed broad spectrum of antimicrobial potential against all the tested plant and human pathogens. Based on the MTT assay, ZnONPs inhibited the proliferation of normal human melanocytes, human breast and liver cancer cell lines with IC50 concentrations of 55·76, 18·02 and 16·87 µg ml−1. ZnONPs exhibited promising antioxidant potential with 50% inhibitory concentration of 102·13 µg ml−1. Moreover, ZnONPs showed efficient degradation of methylene blue dye. Conclusions The synthesized ZnONPs showed promising activities that can be better explored in the near future for many medical, agricultural and industrial applications. Significance and Impact of the Study This study suggests a new and alternate approach with the excellent biotechnological potentiality for the production of ZnONPs which could open up the way for the industrial manufacture of nanoparticles using microbial platforms.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biosynthesis of zinc oxide nanoparticles with antimicrobial, anticancer, antioxidant and photocatalytic activities by the endophytic Alternaria tenuissima

2020

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Vicenin‐2 inhibits the Helicobacterium pylori infection associated gastric carcinogenic events through modulation of PI3K/AKT and Nrf2 signaling in GES‐1 cells

Zhang

Sun

Dong

et al. 2020

J Biochem & Molecular Tox

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Helicobacter pylori (H. pylori), a microbial carcinogen of Gram‐negative bacteria, has been recognized to be the highest risk factor for the growth of human gastric cancer (GC). Therefore, the inhibition of the growth rate of H. pylori has been considered an effective vital strategy to prevent GC development. This study highlights the inhibitory effect of vicenin‐2 against H. pylori‐induced gastric carcinogen signaling in human gastric epithelial cells (GES‐1). In vitro cytotoxicity studies reported that 40 µM of vicenin‐2 remarkably protects the gastric cells and this concentration shows 85% cell viability also does not produce toxicity. In addition, vicenin‐2 prevents H. pylori‐infected increased depletion of antioxidants mediated by reactive oxygen species generation, DNA damage, malondialdehyde, and nuclear fragmentation. Here, we noticed that vicenin‐2 remarkably suppressed the expression range of the phosphorylated form of phosphatidylinositol 3‐kinase/protein kinase B, phosphorylated p38 kinases, phosphorylated extracellular signal‐regulated kinase‐1, phosphorylated c‐Jun N‐terminal kinase, tumor necrosis factor‐α, interleukin‐6, cyclooxygenase‐2 in GES‐1 infected with H. pylori. Moreover, we observed that vicenin‐2 enhanced the antioxidants protein nuclear factor erythroid factor‐2 and phosphatase and tensin homolog expression in H. pylori‐infected cells. Thus, vicenin‐2 prevents the H. pylori‐associated infection, and its resistance might be a potential strategy in preventing GC induced by H. pylori.

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Effect of green synthesized ZnO nanoparticles using Paspalum scrobiculatum grains extract in biological applications

Velsankar

Parvathy

Mohandoss

et al. 2022

Microscopy Res & Technique

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In this report, ZnO nanoparticles were biosynthesized using Paspalum scrobiculatum grains extract for the first time. GC–MS analysis explicated that diethyl phthalate was the major phytocompound with 94.09% in aqueous extract. ZnO nanoparticles formation was confirmed by various physicochemical analyses. HR‐TEM images showed the hexagonal, rectangular shaped nanoparticles in 15–30 nm size. The antioxidant, anti‐inflammatory, and anti‐diabetic analyses showed the effective bioactivity of ZnO nanoparticles in 80 μg/ml concentration with 95.36%, 94.08%, and 91.96%, respectively. The morphological and tissue changes witnessed in larvicidal and insecticidal activities against Culex tritaeniorhynchus and Tribolium castaneum revealed the efficient nature of ZnO nanoparticles in 100 ppm at 48 h and 100 μg/kg at 72 h, respectively. The morphological changes in antibacterial activity demonstrated the bactericidal nature of ZnO nanoparticles against Salmonella typhi and Staphylococcus aureus in 150 μg/ml concentration. The morphological observations in anticancer activity against HepG2 liver cancer cells showed the potent drug features of ZnO nanoparticles in 100 μg/ml concentration with 97.18% of cytotoxicity. The ZnO nanoparticles showed no toxicity against HDF normal cells in lower concentrations and it explicated the biocompatible features of nanoparticles. The Vigna radiata plant growth was efficiently promoted by low (60 ppm) concentration of nanoparticles. The ZnO nanoparticles divulged effective degradation of IPA, EDTA, BQ, and DPBF in 75%, 45%, 55%, and 80% through ROS formation, respectively. Thus, the synthesized ZnO nanoparticles are biocompatible and inexpensive material compared to the traditional one and can be utilized as an efficient material in biological fields. Research Highlights Efficient larvicidal and insecticidal activities were evinced at low IC50 value. The ZnO nanoparticles were non‐toxic to HDP (fibroblast) normal cells. Efficient plant growth was attained at 60 ppm concentration.

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Biofabrication of Zinc Oxide Nanoparticles from Aspergillus niger, Their Antioxidant, Antimicrobial and Anticancer Activity

Cited by 86 publications

References 35 publications

Biosynthesis of zinc oxide nanoparticles with antimicrobial, anticancer, antioxidant and photocatalytic activities by the endophytic Alternaria tenuissima

Biosynthesis of zinc oxide nanoparticles with antimicrobial, anticancer, antioxidant and photocatalytic activities by the endophytic Alternaria tenuissima

Vicenin‐2 inhibits the Helicobacterium pylori infection associated gastric carcinogenic events through modulation of PI3K/AKT and Nrf2 signaling in GES‐1 cells

Effect of green synthesized ZnO nanoparticles using Paspalum scrobiculatum grains extract in biological applications

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