2022
DOI: 10.1021/acsomega.1c07178
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Biofilm-Associated Agr and Sar Quorum Sensing Systems of Staphylococcus aureus Are Inhibited by 3-Hydroxybenzoic Acid Derived from Illicium verum

Abstract: Biofilm-producing Staphylococcus aureus ( S. aureus ) is less sensitive to conventional antibiotics than free-living planktonic cells. Here, we evaluated the antibiofilm activity of Illicium verum ( I. verum ) and one of its constituent compounds 3-hydroxybenzoic acid (3-HBA) against multi-drug-resistant S. aureus . We performed gas chromatography–mass spectroscopy (GC-MS) to identify the major co… Show more

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Cited by 37 publications
(20 citation statements)
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“…They also analyzed the interactions between anethole which is the active ligand of the plant and SarA with −2.723 kcal/mol glide score and recorded that the results were evidence for the inhibition ability of SarA. [ 66 ] Ibrahim et al synthesized 5‐acetyl‐4‐methyl‐2‐(3‐pyridyl) thiazole for evaluating antimicrobial activity and demonstrated several interactions with Gln164, Arg190, and Lys154 as −4.6526 kcal/mol binding energy. [ 67 ] 1‐hydroxy‐1‐norresistomycin was evaluated against human clinical pathogens by Ramalingam et al in vivo and in vitro.…”
Section: Resultsmentioning
confidence: 99%
“…They also analyzed the interactions between anethole which is the active ligand of the plant and SarA with −2.723 kcal/mol glide score and recorded that the results were evidence for the inhibition ability of SarA. [ 66 ] Ibrahim et al synthesized 5‐acetyl‐4‐methyl‐2‐(3‐pyridyl) thiazole for evaluating antimicrobial activity and demonstrated several interactions with Gln164, Arg190, and Lys154 as −4.6526 kcal/mol binding energy. [ 67 ] 1‐hydroxy‐1‐norresistomycin was evaluated against human clinical pathogens by Ramalingam et al in vivo and in vitro.…”
Section: Resultsmentioning
confidence: 99%
“…Trajectory analysis is performed using programs within the GROMACS 5.1.4 (ver 2019.2) software 40 , 41 . The temperature (310 K, normal body temperature) and pressure (1 bar) are kept constant using the V-rescale and Berendsen algorithms, respectively 42 , 43 .…”
Section: Methodsmentioning
confidence: 99%
“…Plant-based bioactive compounds can decrease the expression of disease pathogenesis genes by interacting with QS-associated virulence factors and affecting biofilm formation. Several compounds have previously been shown to have antibiofilm activities, including quercetin, catechin, rosmarinic acid, limonoid, ichangin, apigenin, kaempferol, and naringenin [ 11 ]. It is critical to identify powerful QS inhibitors (QSIs), ideally from natural sources.…”
Section: Introductionmentioning
confidence: 99%
“…It is critical to identify powerful QS inhibitors (QSIs), ideally from natural sources. Plant secondary metabolites may result in the effective treatment of a variety of illnesses [ 11 ].…”
Section: Introductionmentioning
confidence: 99%