Biofilm control with enzymes

Borges, Anabela; Meireles, Ana; Mergulhão, Filipe; Melo, L. F.; Simões, Manuel

doi:10.1016/b978-0-12-819497-3.00011-8

Cited by 14 publications

(7 citation statements)

References 129 publications

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“…Enzyme specificity varies with substrate, inhibitors or activators, the presence or absence of cofactors, pH, and temperature. Temperature and contact time are the most important factors affecting enzyme activities, as high temperatures can result in enzyme denaturation, and the enzyme may start to lose activity over time or become inactivated by the breakdown products (Borges et al, 2020).…”

Section: Antibiofilm Enzymesmentioning

confidence: 99%

Green approaches for biofilm eradication: Enhancing cleaning efficiency

Mechmechani,

Jha,

Karam

et al. 2024

Journal of Food Safety

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Cleaning up biocontamination from surfaces is a critical aspect of maintaining a hygienic environment. Traditional cleaning methods often fall short when it comes to eliminating persistent biofilms and resilient bacteria. In recent years, alternative approaches utilizing antibiofilm enzymes, bacteriophages, essential oils (EOs), antibacterial peptides, and biosurfactants have emerged as promising strategies to combat biocontamination. This article explores the efficiency of these agents in targeting and eradicating biofilms, highlighting their mechanisms of action and potential applications. By leveraging the unique properties of these materials, we can enhance cleaning practices and improve public health outcomes by effectively eliminating biocontamination from various surfaces.

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Section: Antibiofilm Enzymesmentioning

confidence: 99%

Green approaches for biofilm eradication: Enhancing cleaning efficiency

Mechmechani,

Jha,

Karam

et al. 2024

Journal of Food Safety

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“…The principal mechanism by which enzymes inhibit biofilms is attacking the exopolysaccharide (EPS) matrix that surrounds bacterial cells (Borges et al, 2020). However, enzymes can also destroy cell membranes, modify intracellular contents, and disturb the QS-mediated communication process inside cells by disrupting the production and reducing the availability of acyl-homoserine lactones molecules (Figure 5) (Baidamshina et al, 2017;Okshevsky et al, 2015;Thallinger et al, 2013).…”

Section: Enzymesmentioning

confidence: 99%

Promising strategies to control persistent enemies: Some new technologies to combat biofilm in the food industry—A review

Mevo

Ashrafudoulla

Mizan

et al. 2021

Comp Rev Food Sci Food Safe

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Biofilm is an advanced form of protection that allows bacterial cells to withstand adverse environmental conditions. The complex structure of biofilm results from genetic-related mechanisms besides other factors such as bacterial morphology or substratum properties. Inhibition of biofilm formation of harmful bacteria (spoilage and pathogenic bacteria) is a critical task in the food industry because of the enhanced resistance of biofilm bacteria to stress, such as cleaning and disinfection methods traditionally used in food processing plants, and the increased food safety risks threatening consumer health caused by recurrent contamination and rapid deterioration of food by biofilm cells. Therefore, it is urgent to find methods and strategies for effectively combating bacterial biofilm formation and eradicating mature biofilms. Innovative and promising approaches to control bacteria and their biofilms are emerging. These new approaches range from methods based on natural ingredients to the use of nanoparticles. This literature review aims to describe the efficacy of these strategies and provide an overview of recent promising biofilm control technologies in the food processing sector.

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“…Despite being recognized as significant contributors to the onset of various human diseases, our understanding of biofilm-associated infections and effective treatment strategies is in early stages. − Conventional treatment methods often struggle to completely eradicate biofilms. Several treatment strategies have been explored apart from antibiotics to combat and eliminate biofilms, including the use of enzymes or antimicrobial peptides, − quorum sensing inhibitors, − and phage therapy. − …”

Section: Introductionmentioning

confidence: 99%

Pillar[n]arenes in the Fight against Biofilms: Current Developments and Future Perspectives

Jothi Nayaki,

Roja,

Ravindhiran

et al. 2024

ACS Infect. Dis.

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The global surge in bacterial infections, compounded by the alarming escalation of drug-resistant strains, has evolved into a critical public health crisis. Among the challenges posed, biofilms stand out due to their formidable resistance to conventional antibiotics. This review delves into the burgeoning potential of pillar[n]arenes, distinctive macrocyclic host molecules, as promising anti-biofilm agents. The review is structured into two main sections, each dedicated to exploring distinct facets of pillar[n]arene applications. The first section scrutinizes functionalized pillar[n]arenes with a particular emphasis on cationic derivatives. This analysis reveals their significant efficacy in inhibiting biofilm formation, underscoring the pivotal role of specific chemical attributes in combating microbial communities. The second section of the review shifts its focus to inclusion complexes, elucidating how pillar[n]arenes serve as encapsulation platforms for antibiotics. This encapsulation enhances the stability of antibiotics and enables a controlled release, thereby amplifying their antibacterial activity. The examination of inclusion complexes provides valuable insights into the potential synergy between pillar[n]arenes and traditional antibiotics, offering a novel avenue for overcoming biofilm resistance. This comprehensive review highlights the escalating global threat of bacterial infections and the urgent need for innovative strategies to counteract drugresistant biofilms. The unique properties of pillar[n]arenes, both as functionalized molecules and as inclusion complex hosts, position them as promising candidates in the quest for effective anti-biofilm agents. The exploration of their distinct mechanisms opens new avenues for research and development in the ongoing battle against bacterial infections and biofilm-related health challenges.

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Biofilm control with enzymes

Cited by 14 publications

References 129 publications

Green approaches for biofilm eradication: Enhancing cleaning efficiency

Green approaches for biofilm eradication: Enhancing cleaning efficiency

Promising strategies to control persistent enemies: Some new technologies to combat biofilm in the food industry—A review

Pillar[n]arenes in the Fight against Biofilms: Current Developments and Future Perspectives

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