Biofilm formation and antibiotic resistance profiles of water-borne pathogens

Koskeroglu, Kursat; Barel, Mukaddes; Hızlısoy, Harun; Yıldırım, Yeliz

doi:10.1016/j.resmic.2023.104056

Cited by 6 publications

(5 citation statements)

References 31 publications

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“…Secondly, since it has been possible to isolate A. pittii from a wide range of animals including mammals, amphibians, birds, and fish, some of whom have migratory habits, they could also easily function as migration vectors ( Li et al, 2017 ; Morakchi et al, 2017 ; Wang et al, 2020 ; Ying et al, 2020 ; Cevallos et al, 2022 ; Leelapsawas et al, 2022 ). Thirdly, A. pittii has also been isolated from aquatic environments like freshwater and seawater, so these means could facilitate the migration of members of this species from one site to another ( Kong et al, 2021 ; Koskeroglu et al, 2023 ). These observations raise the possibility of genetic exchange between A. pittii strains from different geographical origins.…”

Section: Discussionmentioning

confidence: 99%

Acinetobacter pittii: the emergence of a hospital-acquired pathogen analyzed from the genomic perspective

Bello-López,

Escobedo-Muñoz,

Guerrero

et al. 2024

Front. Microbiol.

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Acinetobacter pittii has increasingly been associated with several types of hospital-acquired severe infections. Genes implicated in carbapenem resistance, tigecycline resistance, or genes encoding extended spectrum cephalosporinases, such as blaADC, are commonly found in isolates implicated in these infections. A. pittii strains that are pandrug resistant have occasionally been identified. Food for human consumption, animals and plants are environmental sources of this pathogen. An alarming situation is that A. pitti has been identified as responsible for outbreaks in different regions worldwide. In this study, 384 genomes of A. pittii were analyzed, comprising sequences from clinical and non-clinical origins from 32 countries. The objective was to investigate if clinical strains possess genetic traits facilitating hospital adaptation. Results indicate significant genomic variability in terms of size and gene content among A. pittii isolates. The core genome represents a small portion (25–36%) of each isolate’s genome, while genes associated with antibiotic resistance and virulence predominantly belong to the accessory genome. Notably, antibiotic resistance genes are encoded by a diverse array of plasmids. As the core genome between environmental and hospital isolates is the same, we can assume that hospital isolates acquired ARGs due to a high selective pressure in these settings. The strain’s phylogeographic distribution indicates that there is no geographical bias in the isolate distribution; isolates from different geographic regions are dispersed throughout a core genome phylogenetic tree. A single clade may include isolates from extremely distant geographical areas. Furthermore, strains isolated from the environment or animal, or plant sources frequently share the same clade as hospital isolates. Our analysis showed that the clinical isolates do not already possess specific genes, other than antibiotic-resistant genes, to thrive in the hospital setting.

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Section: Discussionmentioning

confidence: 99%

Acinetobacter pittii: the emergence of a hospital-acquired pathogen analyzed from the genomic perspective

Bello-López,

Escobedo-Muñoz,

Guerrero

et al. 2024

Front. Microbiol.

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show abstract

“…Secondly, since it has been possible to isolate A. pittii from a wide range of animals including mammals, amphibians, birds, and fish, some of whom have migratory habits, they could also easily function as migration vectors (Li et al, 2017;Morakchi et al, 2017;Wang et al, 2020;Ying et al, 2020;Cevallos et al, 2022;Leelapsawas et al, 2022). Thirdly, A. pittii has also been isolated from aquatic environments like freshwater and seawater, so these means could facilitate the migration of members of this species from one site to another (Kong et al, 2021;Koskeroglu et al, 2023). These observations raise the possibility of genetic exchange between A. pittii strains from different geographical origins.…”

Section: Discussionmentioning

confidence: 99%

Data_Sheet_4.pdf

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“…Secondly, since it has been possible to isolate A. pittii from a wide range of animals including mammals, amphibians, birds, and fish, some of whom have migratory habits, they could also easily function as migration vectors (Li et al, 2017;Morakchi et al, 2017;Wang et al, 2020;Ying et al, 2020;Cevallos et al, 2022;Leelapsawas et al, 2022). Thirdly, A. pittii has also been isolated from aquatic environments like freshwater and seawater, so these means could facilitate the migration of members of this species from one site to another (Kong et al, 2021;Koskeroglu et al, 2023). These observations raise the possibility of genetic exchange between A. pittii strains from different geographical origins.…”

Section: Discussionmentioning

confidence: 99%

Data_Sheet_10.pdf

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Biofilm formation and antibiotic resistance profiles of water-borne pathogens

Cited by 6 publications

References 31 publications

Acinetobacter pittii: the emergence of a hospital-acquired pathogen analyzed from the genomic perspective

Acinetobacter pittii: the emergence of a hospital-acquired pathogen analyzed from the genomic perspective

Data_Sheet_4.pdf

Data_Sheet_10.pdf

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