Biofilm Formation, and Related Impacts on Healthcare, Food Processing and Packaging, Industrial Manufacturing, Marine Industries, and Sanitation–A Review

Shineh, Ghazal; Mobaraki, Mohammadmahdi; Bappy, Mohammad Jabed Perves; Mills, David K.

doi:10.3390/applmicrobiol3030044

Cited by 55 publications

(17 citation statements)

References 288 publications

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“…Our findings show how generic bacterial aspect ratios can influence bacterial advancements in growing colonies. Since biofilm-formation impacts various human activities (41,42), a better understanding of their mechanical determinants can benefit numerous sectors, including ground remediation, biofouling of industrial installations, and changes in human microbiomes. The mechanical advantage of larger aspect ratios uncovered in this manuscript allows for a generic pathway to control biofilms by modifying the length of various bacteria, which is already achievable with existing technologies (43)(44)(45).…”

Section: Discussionmentioning

confidence: 99%

Emergent collective alignment gives competitive advantage to longer cells during range expansion

van den Berg,

Thijssen,

Nguyen

et al. 2024

Preprint

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Bacteria's competition for nutrients and territory drives biofilm evolution (1-4). The factors determining the outcome of competition among diverse bacterial species have a broad impact on a wide range of pathological (5), environmental (6), and microbiome interactions (7). While motility-related traits (8-11) and specific molecular mechanisms (12, 13) have been identified as potential winning attributes in bacteria, a shared and universally conserved feature determining competition remains elusive. Here, we demonstrate that a simple morphological feature of individual bacteria, cell aspect ratio, provides a winning trait for the population. Using range expansion experiments (14), we show that relatively longer bacteria robustly conquer the expanding front, even when initially in minority. Using an agent-based model of dividing bacteria, we reveal that the takeover mechanism is their emergent collective alignment: groups of locally aligned bacteria form 'nematic arms' bridging the central region of the colony to the expanding front. Once at the front, bacteria align parallel to it and block the access of shorter bacteria to nutrients and space. We confirm this observation with single-cell experiments and further generalise our findings by introducing a generic continuum model of alignment dominated competition, explaining both experimental and cell based model observations. Moreover, we extend our predictions to spherical range expansions (15) and confirm the competitive advantage of being longer, even though the effect is less pronounced than in surface attached colonies. Our results uncover a simple, yet hitherto overlooked, mechanical mechanism determining the outcome of bacterial competition, which is potentially ubiquitous among various bacteria. With the current advances in genetic engineering, varying aspect ratios can work as a simple tunable mechanism for the on demand setting of the outcome of bacterial competitions with widespread implications for biofilm control.

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Section: Discussionmentioning

confidence: 99%

Emergent collective alignment gives competitive advantage to longer cells during range expansion

van den Berg,

Thijssen,

Nguyen

et al. 2024

Preprint

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“…The biofilm management remains a complex and ongoing challenge across multiple sectors. Thus, it is imperative to conduct research techniques and tactics for efficiently preventing the formation of bacterial biofilms or eliminating established ones. , …”

Section: Introductionmentioning

confidence: 99%

“…Thus, it is imperative to conduct research techniques and tactics for efficiently preventing the formation of bacterial biofilms or eliminating established ones. 16,17 Recent research works have highlighted the enzymatic method to be a promising strategy for biofilm inhibition. 18 Enzymes are a rich class of antibiofilm agents, displaying various mechanisms for biofilm inhibition and/or disruption.…”

Section: Introductionmentioning

confidence: 99%

Microbial Biofilm Inhibition Using Magnetic Cross-Linked Polyphenol Oxidase Aggregates

Noori,

Bano,

Ahmad

et al. 2024

ACS Appl. Bio Mater.

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Microbial biofilm accumulation poses a serious threat to the environment, presents significant challenges to different industries, and exhibits a large impact on public health. Since there has not been a conclusive answer found despite various efforts, the potential green and economical methods are being focused on, particularly the innovative approaches that employ biochemical agents. In the present study, we propose a bio-nanotechnological method using magnetic cross-linked polyphenol oxidase aggregates (PPO m-CLEA) for inhibition of microbial biofilm including multidrug resistant bacteria. Free PPO solution showed only 55–60% biofilm inhibition, whereas m-CLEA showed 70–75% inhibition, as confirmed through microscopic techniques. The carbohydrate and protein contents in biofilm extracellular polymeric substances (EPSs) were reduced significantly. The m-CLEA demonstrated reusability up to 5 cycles with consistent efficiency in biofilm inhibition. Computational work was also done where molecular docking of PPO with microbial proteins associated with biofilm formation was conducted, resulting in favorable binding scores and inter-residual interactions. Overall, both in vitro and in silico results suggest that PPO interferes with microbial cell attachment and EPS formation, thereby preventing biofilm colonization.

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“…Bacterial colonization can occur on various surfaces in different public places (hospitals, healthcare facilities, universities, public transport) [ 1 ]. A lot of parameters such as shear forces, bacterial motility and electrostatic and hydrodynamic interactions between the surface and microbial cells can contribute to the attachment of pathogens to surfaces [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and Antibiofouling Activities of Carbon Polymerized Dots/Polyurethane and C60/Polyurethane Composite Films

Marković,

Budimir Filimonović,

Milivojević

et al. 2024

JFB

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The cost of treatment of antibiotic-resistant pathogens is on the level of tens of billions of dollars at the moment. It is of special interest to reduce or solve this problem using antimicrobial coatings, especially in hospitals or other healthcare facilities. The bacteria can transfer from medical staff or contaminated surfaces to patients. In this paper, we focused our attention on the antibacterial and antibiofouling activities of two types of photodynamic polyurethane composite films doped with carbon polymerized dots (CPDs) and fullerene C60. Detailed atomic force, electrostatic force and viscoelastic microscopy revealed topology, nanoelectrical and nanomechanical properties of used fillers and composites. A relationship between the electronic structure of the nanocarbon fillers and the antibacterial and antibiofouling activities of the composites was established. Thorough spectroscopic analysis of reactive oxygen species (ROS) generation was conducted for both composite films, and it was found that both of them were potent antibacterial agents against nosocomial bacteria (Klebsiela pneumoniae, Proteus mirabilis, Salmonela enterica, Enterococcus faecalis, Enterococcus epidermis and Pseudomonas aeruginosa). Antibiofouling testing of composite films indicated that the CPDs/PU composite films eradicated almost completely the biofilms of Pseudomonas aeruginosa and Staphylococcus aureus and about 50% of Escherichia coli biofilms.

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Biofilm Formation, and Related Impacts on Healthcare, Food Processing and Packaging, Industrial Manufacturing, Marine Industries, and Sanitation–A Review

Cited by 55 publications

References 288 publications

Emergent collective alignment gives competitive advantage to longer cells during range expansion

Emergent collective alignment gives competitive advantage to longer cells during range expansion

Microbial Biofilm Inhibition Using Magnetic Cross-Linked Polyphenol Oxidase Aggregates

Antibacterial and Antibiofouling Activities of Carbon Polymerized Dots/Polyurethane and C60/Polyurethane Composite Films

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