Biofilm formation in vitro by Leptospira interrogans strains isolated from naturally infected dogs and their role in antimicrobial resistance

Design, green synthesis, and quorum sensing quenching potential of novel 2-oxo-pyridines containing a thiophene/furan scaffold and targeting a LasR gene on P. aeruginosa

“…14,15 In vitro studies have shown that both pathogenic and saprophytic microorganisms e.g., leptospires are capable of forming biolms. 16 Moreover, several studies have observed bacterial aggregates in mammalian hosts' proximal renal tubules, 17,18 and enhanced biolm formation in the presence of catheters. 19 The Pseudomonas aeruginosa is one of the serious pathogens that develops resistance to almost all known conventional antimicrobial drugs, the human population is now in extreme danger, especially immune-compromised patients.…”

“…, leptospires are capable of forming biofilms. 16 Moreover, several studies have observed bacterial aggregates in mammalian hosts' proximal renal tubules, 17,18 and enhanced biofilm formation in the presence of catheters. 19…”