Biofilm formation, virulence and antimicrobial resistance of different Campylobacter jejuni isolates from a poultry slaughterhouse

Prevalence, molecular typing and antimicrobial susceptibility of Campylobacter spp. isolates in northern Spain

“…These data support the results obtained by García‐Sanchez et al who described the ability of Campylobacter to form biofilms and other survival strategies to persist longer in the environment and resist the packaging conditions of modified atmospheres (García‐Sanchez et al . 2018, 2019).…”

Human campylobacteriosis: A public health concern of global importance

“…The Peb4 chaperone is another virulence mechanism in Campylobacter that play a significant role in the exporting of proteins to the outer membrane (Kale et al., 2011). Other virulence genes responsible for stress response genes includes the cosR , cj1556 , spoT , ppk1 , csrA , nuoK and cprS and the cell surface modifications genes ( waaF , pgp1 and peb4 ) (García-Sánchez et al., 2019). All these aforementioned Campylobacter virulence-associated genes have all been reported to be implicated in human infections (Hansson et al., 2018).…”

“…Molecular detection of antimicrobial resistance genes in Campylobacter originating from foods and water samples is a major public health concern of global importance (Elhadidy et al., 2018). Some of the resistance genes detected in Campylobacter species includes quinolone resistance-genes ( gyrA , gyrB and parC ) (Piddock et al., 2003), FQ-resistant ( parE ) (Luangtongkum et al., 2009), β-lactamase (bla OXA-61 and bla OX -184 ), tetracycline resistance genes ( tet A, tet B, tet M, tet O and tet S) (Reddy and Zishri, 2017), aminoglycoside resistance genes ( aphA and aadE ) (García-Sánchez et al., 2019) and erythromycin resistance gene ( erm B) (Wang et al., 2014). Antibiotics resistance genes in Campylobacter are either acquired by spontaneous mutations or through horizontal gene transfer via transduction, conjugation and transformation (Kumar et al., 2016).…”

“…Antibiotics resistance genes in Campylobacter are either acquired by spontaneous mutations or through horizontal gene transfer via transduction, conjugation and transformation (Kumar et al., 2016). Other resistance mechanisms developed by Campylobacter against antimicrobials include genetic mutation (Reddy and Zishiri, 2017), point mutation (Luangtongkum et al., 2009), decreased in membrane permeability due to MOMP (García-Sánchez et al., 2019) and rRNA methylases (Wang et al., 2014). Resistance-nodulation-cell division efflux system, modification of ribosomal target sites and weakening of the interaction of the macrocyclic ring and the tunnel wall of the ribosome are also essential resistance mechanism developed in Campylobacter (Wei, and Kang, 2018).…”

RNA Sequencing Data Sets Identifying Differentially Expressed Transcripts during Campylobacter jejuni Biofilm Formation

“…C ampylobacter jejuni is responsible for a large proportion of bacterial gastroenteritis infections in developed nations and is a precursor to the onset of neuroparalytic conditions such as Guillain-Barré and Fisher syndromes (1)(2)(3). Biofilms have been suggested to play a role in the transmission of this pathogen from animals and birds, where it is part of the normal intestinal flora, to humans, enabling the organism to remain infectious under harsh environmental conditions (4)(5)(6). Using RNA isolated from both biofilm-encased and planktonic cells, we demonstrated that there is a high level of change in the C. jejuni transcriptome during biofilm formation.…”