Biofilm Forming Bacteria Isolated from Intrauterine Devices and Their Susceptibility to Antibiotics

El-Sharkawy, A.A.; Abdel-Latif, Randa S; Kamel, Mai A.

doi:10.12816/0046299

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is characterized by replacement of lactobacilli with opportunistic bacteria and has found to be associated with adverse health problem including sexually transmitted diseases, preterm delivery, intrauterine infection and pelvic inflammatory disease. No matter when the genital tract infection occurs, either before IUD insertion or after the insertion, IUD is a potential reservoir for pathogen microorganisms including Escherichia coli, Candida spp., Staphylococcus aureus and Pseudomonas aeruginosa, which then could lead to antibiotic resistance and persistent infections in IUD users [8,[15][16][17][18]. Although toxic shock syndrome has been rarely seen due to IUD use, a few cases has been reported [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Potential Use of Lactobacillus gasseri G10 Isolated from Human Vagina along with Intrauterine Devices (IUD) to Prevent Pathogen Colonization

Aktaş

2022

Sakarya University Journal of Science

View full text Add to dashboard Cite

Intrauterine devices (IUDs), well effective long-term contraception methods used around the world, are potential reservoir for pathogens and carry risk of reproductive-tract infections such as bacterial vaginosis and vulvovaginal candidiasis. A healthy vagina is dominated by Lactobacillus involved in protecting reproductive system against pathogens. This study aims to investigate the impact of L. gasseri G10 (G10), a vaginal isolate, and its Exopolysaccharide (EPS) on adherence of Staphylococcus aureus and Candida albicans to IUD-tail. Three conditions were simulated to examine if G10 with/without EPS is capable of displacing, excluding, and competing pathogen adhesion to IUD. Inhibitory impact of EPS at various concentrations on pathogen adherence was also evaluated with co-incubation. G10 blocked by co-incubation (97%) and displacement (46%) of S. aureus adherence to IUD tail and displaced C. albicans attached to IUD with about 99%. Compared with S. aureus, the biofilm formation by C. albicans was highly susceptible to EPS. All concentrations of EPS inhibited the adherence of C. albicans (81-97%); however, no significant reductions were observed in S. aureus adherence. Moreover, G10 and EPS together reduced the adherence of both S. aureus (>99%) and C. albicans (94-98%) through all three mechanisms. This study indicates that G10 and its EPS have the ability to inhibit adhesion of S. aureus and C. albicans to IUD and potential use in intravaginal products to prevent/manage IUD associated infections in women. The results suggest development of a new way of applying IUD along with probiotic agents alone or as synbiont.

show abstract

Section: Introductionmentioning

confidence: 99%

Potential Use of Lactobacillus gasseri G10 Isolated from Human Vagina along with Intrauterine Devices (IUD) to Prevent Pathogen Colonization

Aktaş

2022

Sakarya University Journal of Science

View full text Add to dashboard Cite

show abstract

Biofilm Forming Bacteria Isolated from Intrauterine Devices and Their Susceptibility to Antibiotics

Cited by 1 publication

References 0 publications

Potential Use of Lactobacillus gasseri G10 Isolated from Human Vagina along with Intrauterine Devices (IUD) to Prevent Pathogen Colonization

Potential Use of Lactobacillus gasseri G10 Isolated from Human Vagina along with Intrauterine Devices (IUD) to Prevent Pathogen Colonization

Contact Info

Product

Resources

About