Biofilm Inhibition by Natural Products of Marine Origin and Their Environmental Applications

Padmavathi, Alwar Ramanujam; Bakkiyaraj, Dhamodharan; Pandian, Shunmugiah Karutha

doi:10.1002/9781119246329.ch23

Cited by 3 publications

(2 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bacterial biofilms are organized communities of bacterial cells attached and embedded in a self-formed extracellular polysaccharide matrix (EPS) [ 4 ]. The assembled microorganisms present in biofilms may consist of different or the same microbial species and typically grow on organic or inorganic surfaces that serve as a source of nutrients [ 5 ]. Biofilm formation by microorganisms confers advantages such as protection from adverse environmental conditions (desiccation and starvation), host immune defense systems, and antimicrobial substances [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-biofilm, drug delivery and cytotoxicity properties of dendrimers

Ezeh,

Dibua

2024

ADMET DMPK

View full text Add to dashboard Cite

Background and purpose: Treatments using antimicrobial agents have faced many difficulties as a result of biofilm formation by pathogenic microorganisms. The biofilm matrix formed by these microorganisms prevents antimicrobial agents from penetrating the interior where they can exact their activity effectively. Additionally, extracellular polymeric molecules associated with biofilm surfaces can absorb antimicrobial compounds, lowering their bioavailability. This problem has resulted in the quest for alternative treatment protocols, and the development of nanomaterials and devices through nanotechnology has recently been on the rise. Research approach: The literature on dendrimers was searched for in databases such as Google Scholar, PubMed, and ScienceDirect. Key results: As a nanomaterial, dendrimers have found useful applications as a drug delivery vehicle for antimicrobial agents against biofilm-mediated infections to circumvent these defense mechanisms. The distinctive properties of dendrimers, such as multi-valency, biocompatibility, high water solubility, non-immunogenicity, and biofilm matrix-/cell membrane fusogenicity (ability to merge with intracellular membrane or other proteins), significantly increase the efficacy of antimicrobial agents and reduce the likelihood of recurring infections. Conclusion: This review outlines the current state of dendrimer carriers for biofilm treatments, provides examples of their real-world uses, and examines potential drawbacks.

show abstract

Section: Introductionmentioning

confidence: 99%

Anti-biofilm, drug delivery and cytotoxicity properties of dendrimers

Ezeh,

Dibua

2024

ADMET DMPK

View full text Add to dashboard Cite

show abstract

“…Biofilm referred to the intricate three-dimensional (3-D) aggregation of bacteria attached to a surface and buried inflexibly in an Extracellular Polymeric Substance (EPS) matrix. Bacteria form biofilms in every substratum, and their associated infections in plants, animals, and humans ( Lebeaux et al, 2014 ; Padmavathi et al, 2017 ; Kannappan et al, 2020 ). Besides, biofilms also play destructive roles in industrial pipelines corrosion ( Lenhart et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Bacterial Biofilm Inhibition: A Focused Review on Recent Therapeutic Strategies for Combating the Biofilm Mediated Infections

Ramanathan

Santhakumari

Poonguzhali³

et al. 2021

Front. Microbiol.

218

109

View full text Add to dashboard Cite

Biofilm formation is a major concern in various sectors and cause severe problems to public health, medicine, and industry. Bacterial biofilm formation is a major persistent threat, as it increases morbidity and mortality, thereby imposing heavy economic pressure on the healthcare sector. Bacterial biofilms also strengthen biofouling, affecting shipping functions, and the offshore industries in their natural environment. Besides, they accomplish harsh roles in the corrosion of pipelines in industries. At biofilm state, bacterial pathogens are significantly resistant to external attack like antibiotics, chemicals, disinfectants, etc. Within a cell, they are insensitive to drugs and host immune responses. The development of intact biofilms is very critical for the spreading and persistence of bacterial infections in the host. Further, bacteria form biofilms on every probable substratum, and their infections have been found in plants, livestock, and humans. The advent of novel strategies for treating and preventing biofilm formation has gained a great deal of attention. To prevent the development of resistant mutants, a feasible technique that may target adhesive properties without affecting the bacterial vitality is needed. This stimulated research is a rapidly growing field for applicable control measures to prevent biofilm formation. Therefore, this review discusses the current understanding of antibiotic resistance mechanisms in bacterial biofilm and intensely emphasized the novel therapeutic strategies for combating biofilm mediated infections. The forthcoming experimental studies will focus on these recent therapeutic strategies that may lead to the development of effective biofilm inhibitors than conventional treatments.

show abstract

Biochemistry of Bacterial Biofilm: Insights into Antibiotic Resistance Mechanisms and Therapeutic Intervention

Azeem,

Fatima,

Ali

et al. 2025

Life

View full text Add to dashboard Cite

Biofilms, composed of structured communities of bacteria embedded in a self-produced extracellular matrix, pose a significant challenge due to their heightened resistance to antibiotics and immune responses. This review highlights the mechanisms underpinning antibiotic resistance within bacterial biofilms, elucidating the adaptive strategies employed by microorganisms to withstand conventional antimicrobial agents. This encompasses the role of the extracellular matrix, altered gene expression, and the formation of persister cells, contributing to the recalcitrance of biofilms to eradication. A comprehensive understanding of these resistance mechanisms provides a for exploring innovative therapeutic interventions. This study explores promising avenues for future research, emphasizing the necessity of uncovering the specific genetic and phenotypic adaptations occurring within biofilms. The identification of vulnerabilities in biofilm architecture and the elucidation of key biofilm-specific targets emerge as crucial focal points for the development of targeted therapeutic strategies. In addressing the limitations of traditional antibiotics, this review discusses innovative therapeutic approaches. Nanomaterials with inherent antimicrobial properties, quorum-sensing inhibitors disrupting bacterial communication, and bacteriophages as biofilm-specific viral agents are highlighted as potential alternatives. The exploration of combination therapies, involving antimicrobial agents, biofilm-disrupting enzymes, and immunomodulators, is emphasized to enhance the efficacy of existing treatments and overcome biofilm resilience.

show abstract

Biofilm Inhibition by Natural Products of Marine Origin and Their Environmental Applications

Cited by 3 publications

References 94 publications

Anti-biofilm, drug delivery and cytotoxicity properties of dendrimers

Anti-biofilm, drug delivery and cytotoxicity properties of dendrimers

Bacterial Biofilm Inhibition: A Focused Review on Recent Therapeutic Strategies for Combating the Biofilm Mediated Infections

Biochemistry of Bacterial Biofilm: Insights into Antibiotic Resistance Mechanisms and Therapeutic Intervention

Contact Info

Product

Resources

About