Biofilm microenvironment activated supramolecular nanoparticles for enhanced photodynamic therapy of bacterial keratitis

Han, Heyou; Gao, Yifan; Chai, Mengyin; Zhang, Xiaobo; Liu, Shaorui; Huang, Yue; Jin, Qiao; Grzybowski, Andrzej; Ji, Jian; Yao, Ke

doi:10.1016/j.jconrel.2020.09.014

Cited by 114 publications

(68 citation statements)

References 41 publications

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“…118 The bacterial biofilm microenvironment might be a novel target to improve the efficacy of SASMs. 119 Applying SASMs in tissue engineering and regenerative medicine is at the beginning, but there is a concern of amyloidogenicity of aggregates. This issue requires careful kinetic control of the formation of SASMs to avoid inducing amyloid formation of endogenous biomolecules.…”

Section: Discussionmentioning

confidence: 99%

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Biological functions of supramolecular assemblies of small molecules in the cellular environment

Wang

2021

RSC Chem. Biol.

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Section: Discussionmentioning

confidence: 99%

“…More importantly, compared to 23 , 25 has lower toxicity to bone marrow stromal cells, which would reduce the systemic burden. 83 This method likely would be applicable to target other enzymes, such as matrix metalloproteinases 84 and gelatinase, 85 for minimizing MDR.…”

Section: Sasms Inhibit Pathogenic Cellsmentioning

confidence: 99%

Biological functions of supramolecular assemblies of small molecules in the cellular environment

Wang

2021

RSC Chem. Biol.

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“…Negatively charged surface by EEEEEE peptide shell was removed by overexpressed MMP9 in the keratitis microenvironment. Subsequently, the exposed cationic peptides helped the nanoparticles to penetrate and accumulate in biofilms as well as bind to Gram-negative bacteria, thereby improving the antibacterial PDT efficacy ( 58 ). Hyaluronidase secreted by MRSA was also applied as an endogenous stimulus in antibacterial PDT.…”

Section: Unique Microenvironment In Bacterial Infection Tissuesmentioning

confidence: 99%

Stimuli-Responsive Nanoplatform-Assisted Photodynamic Therapy Against Bacterial Infections

Zhou

Deng²,

Mo³

et al. 2021

Front. Med.

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Bacterial infections are common diseases causing tremendous deaths in clinical settings. It has been a big challenge to human beings because of the antibiotics abuse and the newly emerging microbes. Photodynamic therapy (PDT) is a reactive oxygen species-based therapeutic technique through light-activated photosensitizer (PS). Recent studies have highlighted the potential of PDT as an alternative method of antibacterial treatment for its broad applicability and high efficiency. However, there are some shortcomings due to the low selectivity and specificity of PS. Growing evidence has shown that drug delivery nanoplatforms have unique advantages in enhancing therapeutic efficacy of drugs. Particularly, stimuli-responsive nanoplatforms, as a promising delivery system, provide great opportunities for the effective delivery of PS. In the present mini-review, we briefly introduced the unique microenvironment in bacterial infection tissues and the application of PDT on bacterial infections. Then we review the stimuli-responsive nanoplatforms (including pH-, enzymes-, redox-, magnetic-, and electric-) used in PDT against bacterial infections. Lastly, some perspectives have also been proposed to further promote the future developments of antibacterial PDT.

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“…Biofilm is the well-organized protective bacterial communities with encapsulation in self-generated extracellular polymeric substances (EPS), which is mainly consisted of polysaccharides, proteins, and nucleic acids. [6][7][8] The compact EPS of bacterial biofilm can work as an effective and protective physical and metabolic barrier, which not only protects themselves from the attack of host immune system but also induces serious antibiotic resistance by restricting extracellular bacterial DNA. [9][10][11] Additionally, because of the encapsulation of EPS and bacterial fermentation inside the biofilm, the biofilm microenvironment is characterized as hypoxia, lower pH, and higher level of H 2 O 2 and glutathione (GSH) than healthy tissues, [12][13][14] thereby leading to more and more great challenge to eradicate bacterial biofilm infections.…”

Section: Introductionmentioning

confidence: 99%

A Biofilm Microenvironment‐Activated Single‐Atom Iron Nanozyme with NIR‐Controllable Nanocatalytic Activities for Synergetic Bacteria‐Infected Wound Therapy

Hua

Zhang

et al. 2021

Adv Healthcare Materials

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Biofilm microenvironment (BME)-activated antimicrobial agents display great potential for improved biofilm-related infection therapy because of their superior specificities and sensitivities, effective eliminations, and minimal side effects. Herein, BME-activated Fe-doped polydiaminopyridine nanofusiform-mediated single-atom nanozyme (FePN SAzyme) is presented for photothermal/chemodynamic synergetic bacteria-infected wound therapy. The photothermal therapy (PTT) function of SAzyme can be specifically initiated by the high level of H 2 O 2 and further accelerated through mild acid within the inflammatory environment through "two-step rocket launching-like" process. Additionally, the enhanced chemodynamic therapy (CDT) for the FePN SAzyme can also be endowed by producing hydroxyl radicals through reacting with H 2 O 2 and consuming glutathione (GSH) of the BME, thereby contributing to more efficient synergistic therapeutic effect. Meanwhile, FePN SAzyme could catalyze biofilm-overexpressed H 2 O 2 decomposing into O 2 and overcome the hypoxia of biofilm, which significantly enhances the susceptibility of biofilm and increases the synergistic efficacy. Most importantly, the synergistic therapy of bacterial-induced infection diseases can be switched on by the internal and external stimuli simultaneously, resulting in minimal nonspecific damage to healthy tissue. These remarkable characteristics of FePN SAzyme not only develop an innovative strategy for the BME-activated combination therapy but also open a new avenue to explore other nanozyme-involved nanoplatforms for bacterial biofilm infections.

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Biofilm microenvironment activated supramolecular nanoparticles for enhanced photodynamic therapy of bacterial keratitis

Cited by 114 publications

References 41 publications

Biological functions of supramolecular assemblies of small molecules in the cellular environment

Biological functions of supramolecular assemblies of small molecules in the cellular environment

Stimuli-Responsive Nanoplatform-Assisted Photodynamic Therapy Against Bacterial Infections

A Biofilm Microenvironment‐Activated Single‐Atom Iron Nanozyme with NIR‐Controllable Nanocatalytic Activities for Synergetic Bacteria‐Infected Wound Therapy

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