Biofilm production by Staphylococcus epidermidis isolates associated with catheter related bacteremia

Correlation between biofilm formation and production of polysaccharide intercellular adhesin in clinical isolates of coagulase-negative staphylococci

“…Ishak et al (1985) reported that biofilm formation by CoNS blood-stream isolates was similar to that by commensal strains isolated from skin. Vogel et al (2000) found no clear association between biofilm production and the virulence of S. epidermidis isolated from catheter-related infections and nasal colonizers. Go¨tz and Peters (2000) suggested that biofilm production might be an adaptive response of some strains to the presence of a foreign body rather than a necessary virulence factor.…”

Study of virulence factors in coagulase-negative staphylococci isolated from newborns

“…However, in opportunistic situations, these microorganisms cross protection barriers such as the skin and mucosa and colonize sites adjacent to the normal flora. Several authors have emphasized the production of exopolysaccharide or slime as an epidemiological marker of infection (Christensen et al 1982, Hall et al 1987, Vogel 2000. On the other hand, other investigators have found no association between slime-producing strains and the occurrence of infections caused by these microorganisms (Christensen et al 1983, Riley & Schneider 1992).…”

“…Evidence indicates that pathogenicity might be related to the production of an extracellular polysaccharide, known as slime, that permits these microorganisms to adhere to smooth plastic surfaces, colonizing catheters, prosthetic heart valves, pacemakers, and joint prostheses (Vogel et al 2000).…”

Aderência bacteriana in vitro a lentes intra-oculares de polimetilmetacrilato e de silicone

“…No entanto, outros pesquisadores acreditam que a produção de cápsula e a expressão do antíge-no associado à cápsula por isolados clínicos de estafilococos têm forte associação com a habilidade de produzir espessos biofilmes e possivelmente com a virulência do S. epidermidis (12) . Em outro estudo, ficou demonstrado que a média de produção de biofilmes de 22 isolados de S. epidermidis a partir de cateteres relacionados com bacteremia foi significativamente mais alta do que os 32 isolados do nariz de indivíduos saudáveis (28) . Paralelamente, neste caso, não foi encontrada uma clara associação entre produção de biofilme e virulência.…”