Biofilm: The Haven for Staphylococcus epidermidis in Post-operative Endophthalmitis

Nayak, Niranjan

doi:10.4172/2155-9570.1000350

Cited by 1 publication

(1 citation statement)

References 22 publications

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“…Because of its abundance in the conjunctival flora, CNSE is very common. The ability of the organism to effect colonisation while protecting itself from immune responses is believed to be because of the production of a biofilm (slime, an exo-polysaccharide) [18][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

Clinical Profile, Antibiotic Resistance and Outcomes in Bacterial Endophthalmitis: Coagulase-Negative Staphylococcus Endophthalmitis as Compared to Other Organisms

Gaur,

Takkar,

Chandra

et al. 2024

Cureus

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Background: To evaluate the clinical profile, outcomes and antibiotic resistance in bacterial endophthalmitis. Methods: This was a post-hoc analysis of a study conducted at a tertiary centre, where 60 consecutive cases of culture-proven bacterial endophthalmitis were included prospectively. Group 1 included coagulase-negative Staphylococcus endophthalmitis (CNSE), while group 2 included the remaining cases. Clinical features, antibiotic resistance and visual outcomes were compared. Visual acuity >3/60 at six months of follow-up was defined as a good visual outcome. Results: Group 1 had 31 cases, while group 2 had 29. Group 2 included 12 gram-positive and 17 gram-negative isolates. Among the groups, group 2 had more patients with presenting visual acuity below hand motions close to the face (25 vs. 12, p<0.001), poor visual outcomes (26 vs. 3, p<0.001) and retinal detachment (RD) (10 vs. 2, p=0.007). Pseudomonas was most commonly resistant to antibiotics, and ceftazidime (p=0.005) and cefazolin (p=0.009) resistance were higher in group 2 isolates. In group 1, five isolates were resistant to any one of the antibiotics, whereas in group 2, 13 isolates were resistant to any one of the antibiotics (p=0.024). Conclusions: In the current study, eyes in the group of endophthalmitis caused by CNSE achieved better visual acuities at the last follow-up compared to eyes with endophthalmitis caused by other bacteria. Antibiotic resistance in isolates other than CNSE is a cause of concern.

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Section: Discussionmentioning

confidence: 99%