Biofilms and effective porosity of hernia mesh: are they silent assassins?

Jacombs, Anita; Karatassas, Alex; Klosterhalfen, B.; Richter, Katharina; Patiniott, Paul; Hensman, Chris

doi:10.1007/s10029-019-02063-y

Cited by 22 publications

(28 citation statements)

References 27 publications

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“…Jacombs, the dual concepts of effective porosity and biofilm may be crucial in mesh-related morbidity and should be investigated further. Developing new mesh implants to maintain effective porosity and reduce biofilm formation may help reduce mesh-related complications [52].…”

Section: Pore Sizementioning

confidence: 99%

The Role of Mesh Implants in Surgical Treatment of Parastomal Hernia

et al. 2021

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A parastomal hernia is a common complication following stoma surgery. Due to the large number of hernial relapses and other complications, such as infections, adhesion to the intestines, or the formation of adhesions, the treatment of hernias is still a surgical challenge. The current standard for the preventive and causal treatment of parastomal hernias is to perform a procedure with the use of a mesh implant. Researchers are currently focusing on the analysis of many relevant options, including the type of mesh (synthetic, composite, or biological), the available surgical techniques (Sugarbaker’s, “keyhole”, or “sandwich”), the surgical approach used (open or laparoscopic), and the implant position (onlay, sublay, or intraperitoneal onlay mesh). Current surface modification methods and combinations of different materials are actively explored areas for the creation of biocompatible mesh implants with different properties on the visceral and parietal peritoneal side. It has been shown that placing the implant in the sublay and intraperitoneal onlay mesh positions and the use of a specially developed implant with a 3D structure are associated with a lower frequency of recurrences. It has been shown that the prophylactic use of a mesh during stoma formation significantly reduces the incidence of parastomal hernias and is becoming a standard method in medical practice.

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Section: Pore Sizementioning

confidence: 99%

The Role of Mesh Implants in Surgical Treatment of Parastomal Hernia

et al. 2021

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“…5,6 This is reasonable as operative care is not compromised through entrusting a registrar with either certain steps of a procedure or even the whole operation under supervision of the consultant. [7][8][9] Training in private practice appears very achievable in modern day surgical practice, given that patients understand they receive care from a team of individuals led by their specialist. The key to ongoing involvement of registrars in these operations is a preoperative discussion between the surgeon and patient about how their care will not be adversely affected from the trainee's involvement in the procedure.…”

Section: Role Of Private Practice In General Surgical Training In Ausmentioning

confidence: 99%

“…7 It is likely that the presence of bacterial biofilms contributes to the pathogenesis of mesh infections. 8 Some therapies have been shown to decrease the risk of infection. Some advocate biologics in high-risk situations; however, break down after implantation with the potential for hernia recurrence has plagued this mesh type.…”

Section: Introductionmentioning

confidence: 99%

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The Promise of viral phage therapy in hernia mesh infection, is this the biological ‘silver bullet’ of the future?

Speck

Warner

Clark

et al. 2020

ANZ Journal of Surgery

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“…Protected by this barrier, bacteria are strongly attached to the substrate and exert high resistance to the action of antibiotics and host defense cells [ 7 ], events that make biofilm-based infections extremely difficult to treat. Most of these infections, either involving biofilms or not, are caused by Staphylococcus aureus and S. epidermidis [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Development of Biocomposite Polymeric Systems Loaded with Antibacterial Nanoparticles for the Coating of Polypropylene Biomaterials

et al. 2020

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The development of a biocomposite polymeric system for the antibacterial coating of polypropylene mesh materials for hernia repair is reported. Coatings were constituted by a film of chitosan containing randomly dispersed poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles loaded with chlorhexidine or rifampicin. The chlorhexidine-loaded system exhibited a burst release during the first day reaching the release of the loaded drug in three or four days, whereas rifampicin was gradually released for at least 11 days. Both antibacterial coated meshes were highly active against Staphylococcus aureus and Staphylococcus epidermidis (106 CFU/mL), displaying zones of inhibition that lasted for 7 days (chlorhexidine) or 14 days (rifampicin). Apparently, both systems inhibited bacterial growth in the surrounding environment, as well as avoided bacterial adhesion to the mesh surface. These polymeric coatings loaded with biodegradable nanoparticles containing antimicrobials effectively precluded bacterial colonization of the biomaterial. Both biocomposites showed adequate performance and thus could have potential application in the design of antimicrobial coatings for the prophylactic coating of polypropylene materials for hernia repair.

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Biofilms and effective porosity of hernia mesh: are they silent assassins?

Cited by 22 publications

References 27 publications

The Role of Mesh Implants in Surgical Treatment of Parastomal Hernia

The Role of Mesh Implants in Surgical Treatment of Parastomal Hernia

The Promise of viral phage therapy in hernia mesh infection, is this the biological ‘silver bullet’ of the future?

Development of Biocomposite Polymeric Systems Loaded with Antibacterial Nanoparticles for the Coating of Polypropylene Biomaterials

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