Biofilms associated with biomedical implants and combating therapies

Nagaiah, Hari Prasath; Kandaswamy, Karthikeyan; Priya, Arumugam; Kasthuri, Thirupathi; Pandian, Shunmugiah Karutha

doi:10.1016/b978-0-323-99977-9.00030-2

Understanding Microbial Biofilms 2023

DOI: 10.1016/b978-0-323-99977-9.00030-2

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Biofilms associated with biomedical implants and combating therapies

Hari Prasath Nagaiah

Karthikeyan Kandaswamy

Arumugam Priya

et al.

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Development of antibacterial neural stimulation electrodes via hierarchical surface restructuring and atomic layer deposition

Khosla,

Seche,

Ammerman

et al. 2023

Sci Rep

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Miniaturization and electrochemical performance enhancement of electrodes and microelectrode arrays in emerging long-term implantable neural stimulation devices improves specificity, functionality, and performance of these devices. However, surgical site and post-implantation infections are amongst the most devastating complications after surgical procedures and implantations. Additionally, with the increased use of antibiotics, the threat of antibiotic resistance is significant and is increasingly being recognized as a global problem. Therefore, the need for alternative strategies to eliminate post-implantation infections and reduce antibiotic use has led to the development of medical devices with antibacterial properties. In this work, we report on the development of electrochemically active antibacterial platinum-iridium electrodes targeted for use in neural stimulation and sensing applications. A two-step development process was used. Electrodes were first restructured using femtosecond laser hierarchical surface restructuring. In the second step of the process, atomic layer deposition was utilized to deposit conformal antibacterial copper oxide thin films on the hierarchical surface structure of the electrodes to impart antibacterial properties to the electrodes with minimal impact on electrochemical performance of the electrodes. Morphological, compositional, and structural properties of the electrodes were studied using multiple modalities of microscopy and spectroscopy. Antibacterial properties of the electrodes were also studied, particularly, the killing effect of the hierarchically restructured antibacterial electrodes on Escherichia coli and Staphylococcus aureus—two common types of bacteria responsible for implant infections.

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Development of antibacterial neural stimulation electrodes via hierarchical surface restructuring and atomic layer deposition

Khosla,

Seche,

Ammerman

et al. 2023

Sci Rep

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show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

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Biofilms associated with biomedical implants and combating therapies

Cited by 1 publication

References 72 publications

Development of antibacterial neural stimulation electrodes via hierarchical surface restructuring and atomic layer deposition

Development of antibacterial neural stimulation electrodes via hierarchical surface restructuring and atomic layer deposition

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