Biofilms in Human Health

Das, Surojeet; Singh, Shivani; Matchado, Monica Steffi; Srivastava, Aashna; Bajpai, Akash

doi:10.1007/978-3-030-30757-8_3

Cited by 7 publications

(8 citation statements)

References 62 publications

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“…It is estimated that dental infections impact over 3.5 billion people globally, with most cases occurring in economically underdeveloped countries [ 30 ]. In addition to caries and periodontitis, several systemic infections have been associated with bacteria found in oral biofilms, including cardiovascular diseases, atherosclerosis, infective endocarditis, aspiration pneumonia, diabetes mellitus, preterm birth, and low-birth-weight babies [ 31 , 32 ]. Dental plaque or biofilms in the oral cavity contain dextran and glucan, which are products of dental pathogens, such as S. mutans and Streptococcus sobrinus [ 33 ].…”

Section: Biofilm Infectionsmentioning

confidence: 99%

Recent Advances in the Control of Clinically Important Biofilms

Krukiewicz

Kazek-Kęsik

Brzychczy-Włoch

et al. 2022

IJMS

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Biofilms are complex structures formed by bacteria, fungi, or even viruses on biotic and abiotic surfaces, and they can be found in almost any part of the human body. The prevalence of biofilm-associated diseases has increased in recent years, mainly because of the frequent use of indwelling medical devices that create opportunities for clinically important bacteria and fungi to form biofilms either on the device or on the neighboring tissues. As a result of their resistance to antibiotics and host immunity factors, biofilms have been associated with the development or persistence of several clinically important diseases. The inability to completely eradicate biofilms drastically increases the burden of disease on both the patient and the healthcare system. Therefore, it is crucial to develop innovative ways to tackle the growth and development of biofilms. This review focuses on dental- and implant-associated biofilm infections, their prevalence in humans, and potential therapeutic intervention strategies, including the recent advances in pharmacology and biomedical engineering. It lists current strategies used to control the formation of clinically important biofilms, including novel antibiotics and their carriers, antiseptics and disinfectants, small molecule anti-biofilm agents, surface treatment strategies, and nanostructure functionalization, as well as multifunctional coatings particularly suitable for providing antibacterial effects to the surface of implants, to treat either dental- or implant-related bacterial infections.

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Section: Biofilm Infectionsmentioning

confidence: 99%

Recent Advances in the Control of Clinically Important Biofilms

Krukiewicz

Kazek-Kęsik

Brzychczy-Włoch

et al. 2022

IJMS

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“…6,7 Bacterial biofilms can be beneficial in nature as they improve organisms' defenses 8,9 and play an important role in industrial processes such as wastewater treatment. 10,11 Moreover, they are also used in bioremediation procedures 12 and biofuel 13 and chemical 14 production processes. However, in many industrial processes and medical fields, bacterial biofilms can be detrimental.…”

Section: Introductionmentioning

confidence: 99%

“…Biofilms constitute a very stable ecosystem, comprising communities of microorganisms, adhering to surfaces via extracellular polymeric substances (EPSs) produced by the microorganisms themselves. These substances are mainly proteins and polysaccharides that protect the biofilms by retaining the microorganisms together, resulting in the formation of stable structures. , Unlike their planktonic counterparts, bacteria within the biofilm have a different phenotype, leading to different growth rates, genetic material exchange, and communication of the cells via quorum sensing. , Additionally, bacteria growing in a biofilm show great resistance to chemical and mechanical agents, tolerating antimicrobial concentrations 10–1000-fold higher than the free-floating planktonic cells. , Bacterial biofilms can be beneficial in nature as they improve organisms’ defenses , and play an important role in industrial processes such as wastewater treatment. , Moreover, they are also used in bioremediation procedures and biofuel and chemical production processes. However, in many industrial processes and medical fields, bacterial biofilms can be detrimental .…”

Section: Introductionmentioning

confidence: 99%

Wetting and Imbibition Characteristics of Pseudomonas fluorescens Biofilms Grown on Stainless Steel

et al. 2022

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This study aims to provide insights into biofilm resistance associated with their structural properties acquired during formation and development. On this account, the wetting and imbibition behavior of dehydrated Pseudomonas fluorescens biofilms grown on stainless steel electropolished substrates is thoroughly examined at different biofilm ages. A polar liquid (water) and a non-polar liquid (diiodomethane) are employed as wetting agents in the form of sessile droplets. A mathematical model is applied to appraise the wetting and imbibition performance of biofilms incorporating the evaporation of sessile droplets. The present results show that the examined biofilms are hydrophilic. The progressive growth of biofilms leads to a gradual increase of substrate surface coverage�up to full coverage�accompanied by a gradual decrease of biofilm surface roughness. It is noteworthy that just after 24 h of biofilm growth, the surface roughness increases about 6.7 times the roughness of the clean stainless steel surface. It is further found that the imbibition of liquid in the biofilm matrix is restricted only to the biofilm region under the sessile droplet. The lack of further capillary imbibition into the biofilm structure, beyond the droplet deposition region, implies that the biofilm matrix is not in the form of an extended network of interconnected micro/nanopores. All in all, the present results indicate a resilient biofilm structure to biocide penetration despite its hydrophilic nature.

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“…Microorganisms are typically found adhered on biotic or abiotic surfaces as complex sessile communities embedded in a matrix of extracellular polymeric substances (EPS) that they produce [1,2]. According to the National Institute of Health, it is estimated that 80% of microbial infections in humans are biofilm related and affect 1.4 million people annually [3], promoting disease transmission, prolonged hospitalization and additional clinical procedures, thus increasing healthcare costs, and mortality and morbidity rates [4,5]. Most bacterial-associated infections, including endocarditis, dental caries, middle ear infections, osteomyelitis, medical device-related infections, and chronic lung infections in patients with cystic fibrosis, are problematic or untreatable because of biofilms.…”

Section: Introductionmentioning

confidence: 99%

Biofilm control by ionic liquids

Simões

Pereira

Simões

et al. 2021

Drug Discovery Today

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Ionic liquids (ILs) are remarkable chemical compounds with applications in many areas of modern science. They are increasingly recognized as promising compounds to fight microorganisms in both planktonic and biofilm states, contributing to reinvent the antimicrobial pipeline. Biofilm-related infections are particularly challenging given that the scientific community has not yet identified a reliable control strategy. Understanding of the action of ILs in biofilm control is is still in a very early stage. However, given the highly tunable nature and exceptional properties of ILs, they are excellent candidates for biofilm control. Here, we review the major advances in, and challenges tothe use of ILs for effective biofilm control.

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Biofilms in Human Health

Cited by 7 publications

References 62 publications

Recent Advances in the Control of Clinically Important Biofilms

Recent Advances in the Control of Clinically Important Biofilms

Wetting and Imbibition Characteristics of Pseudomonas fluorescens Biofilms Grown on Stainless Steel

Biofilm control by ionic liquids

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