Bioflavonoid-Mediated Stabilization of Collagen in Adjuvant-Induced Arthritis

Rao, C. N.; Rao, Velidi H.; Steinmann, B

doi:10.3109/03009748309102002

Cited by 18 publications

(11 citation statements)

References 18 publications

(14 reference statements)

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“…PA from cranberry inhibited the surface-adsorbed gluocsyltransferases and F-ATP activities, and the acid production by Streptococcus mutans (23). Studies have also shown that PAs increased collagen synthesis and accelerated the conversion of soluble collagen to insoluble collagen during development (24, 25). PA-treated collagen matrices were demostrated to be nontoxic and resisted enzyme digestion in vitro and in vivo (26).…”

Section: Introductionmentioning

confidence: 99%

In vitro remineralization effects of grape seed extract on artificial root caries

Xie

Bedran-Russo

2008

Journal of Dentistry

179

158

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Grape seed extract (GSE) contains Proanthocyanidin (PA), which has been reported to strengthen collagen-based tissues by increasing collagen cross-links. We used an in vitro pH-cycling model to evaluate the effect of GSE on the remineralization of artificial root caries. Sound human teeth fragments obtained from the cervical portion of the root were stored in a demineralization solution for 96 hr at 37°C to induce artificial root caries lesions. The fragments were then divided into three treatment groups including: 6.5% GSE, 1,000 ppm fluoride (NaF), and a control (no treatment). The demineralized samples were pH-cycled through treatment solutions, acidic buffer and neutral buffer for 8 days at 6 cycles per day. The samples were subsequently evaluated using a microhardness tester; polarized light microscopy (PLM) and confocal laser scanning microscopy (CLSM). Data were analyzed using ANOVA and Fisher's tests (p<0.05). GSE and fluoride significantly increased the microhardness of the lesions (p<0.05) when compared to a control group. PLM data revealed a significantly thicker mineral precipitation band on the surface layer of the GSE treated lesions when compared to the other groups (p>0.05), which was confirmed by CLSM. We concluded that grape seed extract positively affects the demineralization and/or remineralization processes of artificial root caries lesions, most likely through a different mechanism than that of Fluoride. Grape seed extract may be a promising natural agent for non-invasive root caries therapy.

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Section: Introductionmentioning

confidence: 99%

In vitro remineralization effects of grape seed extract on artificial root caries

Xie

Bedran-Russo

2008

Journal of Dentistry

179

158

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“…Proanthocyanidins (PAs) are widespread in fruits and vegetables and belong to the category known as condensed tannins, which consist of highly hydroxylated structures capable of forming insoluble complexes with carbohydrates and protein 27, 28. Available evidence shows that PAs increase collagen synthesis and accelerate the conversion of soluble collagen to insoluble collagen during development 29. Han et al30 have investigated the cytotoxicity, crosslinking rate, and biocompatibility of PAs as collagen tissue fixative.…”

Section: Introductionmentioning

confidence: 99%

Chitosan/gelatin–based films crosslinked by proanthocyanidin

et al. 2005

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Novel polymer networks consisting of crosslinked gelatin/chitosan were prepared by a solution casting technique. Methods for bulk crosslinking were developed to modify the gelatin/chitosan blends with the use of a nontoxic crosslinking reagent, proanthocyanidin (PA). FTIR spectral analyses of the preparations showed network formations of crosslinked gelatin, chitosan, and PA by amide and ester linkages. The crosslinked networks were stable in the aqueous state, and had improved mechanical properties and thermal stability when compared with nonlinked gelatin (G) and chitosan/gelatin (C/G) films. In vitro protease digestion and cell-culture studies showed that the PA-crosslinked C/G films are nontoxic and exhibited decreased biodegradation rate and a better ability to support cell adhesion and proliferation than noncrosslinked gelatin or chitosan alone. These results suggest that such a nontoxic crosslinked gelatin/chitosan scaffold can become a promising matrix for tissue-engineering applications.

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“…Chemical cross-linkers have been reported to further stabilize collagen fibrils in several connective tissues (Rao et al, 1983;Cheung et al, 1990;Sung et al, 1999;Ritter et al, 2001;Han et al, 2003;Bedran-Russo et al, 2007). Glutaraldehyde, a widely used synthetic cross-linker, can enhance collagen stability; however, it presents some drawbacks, such as toxicity (Cheung et al, 1990;Southern et al, 2000).…”

Section: Introduction Tmentioning

confidence: 99%

Effects of Chemical Cross-linkers on Caries-affected Dentin Bonding

2009

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A supplemental appendix to this article is published electronically only at http://jdr.sagepub.com/supplemental. AbstrAct The achievement of a strong and stable bond between composite resin and dentin remains a challenge in restorative dentistry. Over the past two decades, dental materials have been substantially improved, with better handling and bonding characteristics. However, little attention has been paid to the contribution of collagen structure/stability to bond strength. We hypothesized that the induction of cross-linking in dentin collagen improves dentin collagen stability and bond strength. This study investigated the effects of glutaraldehyde-and grape seed extract-induced cross-linking on the dentin bond strengths of sound and caries-affected dentin, and on the stability of dentin collagen. Our results demonstrated that the application of chemical cross-linking agents to etched dentin prior to bonding procedures significantly enhanced the dentin bond strengths of caries-affected and sound dentin. Glutaraldehyde and grape seed extract significantly increased dentin collagen stability in sound and caries-affected dentin, likely via distinct mechanisms.

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Bioflavonoid-Mediated Stabilization of Collagen in Adjuvant-Induced Arthritis

Cited by 18 publications

References 18 publications

In vitro remineralization effects of grape seed extract on artificial root caries

In vitro remineralization effects of grape seed extract on artificial root caries

Chitosan/gelatin–based films crosslinked by proanthocyanidin

Effects of Chemical Cross-linkers on Caries-affected Dentin Bonding

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