Biofouling on protective coatings for implantable MEMS

Clausen, Ingelin; Seeberg, Trine M.; Gheorghe, Codin; Wang, Dag T.

doi:10.1109/icsens.2010.5690789

Cited by 6 publications

(4 citation statements)

References 10 publications

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“…Changes in device characteristics after depositing thin biocompatible coatings by Atomic Layer Deposition (ALD) were investigated [ 48 ]. Also device characteristics were examined after submersion in human liver extract [ 49 ] and after more than 30 days submersion in true human synovial fluid [ 50 ]. The results were promising for the development of miniaturized sensors for long-term in vivo measurements, although realistic in vivo tests are still required.…”

Section: Packagingmentioning

confidence: 99%

Development of Clinically Relevant Implantable Pressure Sensors: Perspectives and Challenges

Clausen

Glott

2014

Sensors

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This review describes different aspects to consider when developing implantable pressure sensor systems. Measurement of pressure is in general highly important in clinical practice and medical research. Due to the small size, light weight and low energy consumption Micro Electro Mechanical Systems (MEMS) technology represents new possibilities for monitoring of physiological parameters inside the human body. Development of clinical relevant sensors requires close collaboration between technological experts and medical clinicians. Site of operation, size restrictions, patient safety, and required measurement range and resolution, are only some conditions that must be taken into account. An implantable device has to operate under very hostile conditions. Long-term in vivo pressure measurements are particularly demanding because the pressure sensitive part of the sensor must be in direct or indirect physical contact with the medium for which we want to detect the pressure. New sensor packaging concepts are demanded and must be developed through combined effort between scientists in MEMS technology, material science, and biology. Before launching a new medical device on the market, clinical studies must be performed. Regulatory documents and international standards set the premises for how such studies shall be conducted and reported.

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Section: Packagingmentioning

confidence: 99%

Development of Clinically Relevant Implantable Pressure Sensors: Perspectives and Challenges

Clausen

Glott

2014

Sensors

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“…At present parylene is widely used as an ultrathin medical stent coating. Parylene"" 197 nm thin was applied onto a MEMS-acoustic resonator with negligible resonance frequency changes [Clausen et al, 2010]. In 2014 researchers demonstrated significant advances in the evaluation of a telemetric stent for wireless intravessel pressure monitoring in pigs [Chen et al, 2010].…”

Section: Advanced Development Of Medical Devicesmentioning

confidence: 99%

Development of An Invasive Device for Long-term Remote Monitoring of Cardiovascular System Parameters, Including Blood Pressure, in Patients with Comorbid Conditions

Stupin¹,

Silina²,

Оганов³

et al. 2015

Biosci., Biotechnol. Res. Asia

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The aim of the study is to develop an invasive device for long-term remote monitoring of cardiovascular system parameters, including blood pressure, in patients with comorbid conditions. Such a device is an important solution of a medical problemcontinuous monitoring of patients with hypertension, arrhythmias, chronic heart failure and other comorbid vascular conditions.We developed a pilot model of a device for longterm remote monitoring of blood pressure (systolic, diastolic, mean), heart rate and other calculable parameters of cardiovascular system. We developed a model of a capacitive sensor based on a microelectromechanical system technology (MEMS), equipped with a continuously-adjustable capacitor, wireless data communication and electric power supply. Transmitter model is developed. Engineering tests of device prototype were performed. Experimental work demonstrating the feasibility of converting the collected signals into mm of Hg for the measurement of blood pressure changes and steady radiosignal transduction to the transmitter was performed. A variant of biocompatible cover was chosen-silicone and parylene C. The sensor is designed to be implanted into human or animal body and can be situated either in the vessel lumen or on the vessel wall.

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“…This innovative solution allows for precise physiological recordings during natural bladder filling and emptying cycles. By employing protective coatings, this sensor system offers a reliable and minimally invasive approach for urinary bladder monitoring, facilitating valuable insights for medical experts [15,16]. Clausen's solution show how the integration of biocompatible coatings with MEMS devices presents new opportunities for developing miniaturized implantable medical sensors in various applications.…”

Section: Introductionmentioning

confidence: 99%

An Evaluation of Parylene Thin Films to Prevent Encrustation for a Urinary Bladder Pressure MEMS Sensor System

Buchwalder,

Hersberger,

Rebl

et al. 2023

Polymers

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Recent developments in urological implants have focused on preventive strategies to mitigate encrustation and biofilm formation. Parylene, a conformal, pinhole-free polymer coating, has gained attention due to its high biocompatibility and chemical resistance, excellent barrier properties, and low friction coefficient. This study aims to evaluate the effectiveness of parylene C in comparison to a parylene VT4 grade coating in preventing encrustation on a urinary bladder pressure MEMS sensor system. Additionally, silicon oxide (SiOx) applied as a finish coating was investigated for further improvements. An in vitro encrustation system mimicking natural urine flow was used to quantify the formation of urinary stones. These stones were subsequently analyzed using Fourier transform infrared spectrometry (FTIR). Encrustation results were then discussed in relation to coating surface chemical properties. Parylene C and VT4 grades demonstrated a very low encrustation mass, making them attractive options for encrustation prevention. The best performance was achieved after the addition of a hydrophilic SiOx finish coating on parylene VT4 grade. Parylene-based encapsulation proved to be an outstanding solution to prevent encrustation for urological implants.

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Biofouling on protective coatings for implantable MEMS

Cited by 6 publications

References 10 publications

Development of Clinically Relevant Implantable Pressure Sensors: Perspectives and Challenges

Development of Clinically Relevant Implantable Pressure Sensors: Perspectives and Challenges

Development of An Invasive Device for Long-term Remote Monitoring of Cardiovascular System Parameters, Including Blood Pressure, in Patients with Comorbid Conditions

An Evaluation of Parylene Thin Films to Prevent Encrustation for a Urinary Bladder Pressure MEMS Sensor System

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