Biofriendly bonding processes for nanoporous implantable SU-8 microcapsules for encapsulated cell therapy

Nemani, Krishnamurthy V.; Kwon, Joonbum; Trivedi, Krutarth; Hu, Walter; Lee, Jeong; Gimi, Barjor

doi:10.3109/02652048.2011.621552

Cited by 6 publications

(6 citation statements)

References 17 publications

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“…SU-8 pads (2.5 mm × 2.5 mm × 200 μm) were fabricated on a silicon wafer as reported earlier [28]. Omnicoat was spun on a silicon wafer at 3000 rpm and baked at 200 °C for 2 min.…”

Section: Methodsmentioning

confidence: 99%

In vitro and in vivo evaluation of SU-8 biocompatibility

Nemani

Moodie

Brennick

et al. 2013

Materials Science and Engineering: C

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224

161

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SU-8 negative photoresist is a high tensile strength polymer that has been used for a number of biomedical applications that include cell encapsulation and neuronal probes. Chemically, SU-8 comprises, among other components, an epoxy based monomer and antimony salts, the latter being a potential source of cytotoxicity. We report on the in vitro and in vivo evaluation of SU-8 biocompatibility based on leachates from various solvents, at varying temperature and pH, and upon subcutaneous implantation of SU-8 substrates in mice. MTT cell viability assay did not exhibit any cytotoxic effects from the leachates. The hemolytic activity of SU-8 is comparable to that of FDA approved implant materials such as silicone elastomer, Buna-S and medical steel. In vivo histocompatibility study in mice indicates a muted immune response to subcutaneous SU-8 implants.

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“…SU-8 pads (2.5 mm × 2.5 mm × 200 μm) were fabricated on a silicon wafer as reported earlier [28]. Omnicoat was spun on a silicon wafer at 3000 rpm and baked at 200 °C for 2 min.…”

Section: Methodsmentioning

confidence: 99%

In vitro and in vivo evaluation of SU-8 biocompatibility

Nemani

Moodie

Brennick

et al. 2013

Materials Science and Engineering: C

Self Cite

224

161

View full text Add to dashboard Cite

show abstract

“…9 10 SU-8 is an epoxy-based negative photo resist used extensively for numerous applications of bio MEMS, including microfluidics, biochips, or implantable microelectrode arrays. [11][12][13][14] One study reported that a pH sensor microchip encapsulated by SU-8 with a thickness of 150 m was durable for more than one week. 15 In another study, an electrode selectively insulated by SU-8 was implanted subcutaneously in a rodent model and SU-8 resist was evaluated.…”

Section: Introductionmentioning

confidence: 99%

Impedance Characterization of the Degradation of Insulating Layer Patterned on Interdigitated Microelectrode

Lee¹,

Kim²,

Cho³

2015

j nanosci nanotechnol

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Life-time and functionality of planar microelectrode-based devices are determined by not only the corrosion-resistance of the electrode, but also the durability of the insulation layer coated on the transmission lines. Degradation of the insulating layer exposed to a humid environment or solution may cause leakage current or signal loss, and a decrease in measurement sensitivity. In this study, degradation of SU-8, an epoxy-based negative photoresist and insulating material, patterned on Au interdigitated microelectrode (IDE) for long-term (>30 days) immersion in an electrolyte at 37 °C was investigated by electrical impedance spectroscopy and theoretical equivalent circuit modeling. From the experiment and simulation results, it was found that the degradation level of the insulating layer of the IDE electrode can be characterized by monitoring the resistance of the insulating layer among the circuit parameters of the designed equivalent circuit modeling.

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“…Specifically, they demonstrated a technique that results in biofriendly assembly of nanoporouos microcages [39] that are transparent to light and radio waves to enable the nondestructive imaging of their contents [40]. Additionally, they demonstrated a high-throughput method to create reproducible nanopores on one face of the box microcontainer, not previously available [41].…”

Section: Nanoporous Microcagesmentioning

confidence: 99%

Applications of Semiconductor Fabrication Methods to Nanomedicine: A Review of Recent Inventions and Techniques

Rajasekhar¹,

Gimi²,

Hu³

2013

PNM

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We live in a world of convergence where scientific techniques from a variety of seemingly disparate fields are being applied cohesively to the study and solution of biomedical problems. For instance, the semiconductor processing field has been primarily developed to cater to the needs of the ever decreasing transistor size and cost while increasing functionality of electronic circuits. In recent years, pioneers in this field have equipped themselves with a powerful understanding of how the same techniques can be applied in the biomedical field to develop new and efficient systems for the diagnosis, analysis and treatment of various conditions in the human body. In this paper, we review the major inventions and experimental methods which have been developed for nano/micro fluidic channels, nanoparticles fabricated by top-down methods, and in-vivo nanoporous microcages for effective drug delivery. This paper focuses on the information contained in patents as well as the corresponding technical publications. The goal of the paper is to help emerging scientists understand and improvise over these inventions.

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Biofriendly bonding processes for nanoporous implantable SU-8 microcapsules for encapsulated cell therapy

Cited by 6 publications

References 17 publications

In vitro and in vivo evaluation of SU-8 biocompatibility

In vitro and in vivo evaluation of SU-8 biocompatibility

Impedance Characterization of the Degradation of Insulating Layer Patterned on Interdigitated Microelectrode

Applications of Semiconductor Fabrication Methods to Nanomedicine: A Review of Recent Inventions and Techniques

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