Biofunctional Constituents from Liriodendron tulipifera with Antioxidants and Anti-Melanogenic Properties

Abstract

From the stems of Liriodendron tulipifera, seventeen known compounds have been extracted, isolated and purified. By using spectroscopic analysis, the structures of these pure constituents were determined as three lignans, four steroids and ten benzenoids. Identified compounds were screened for antioxidant abilities using: 1,1-diphenyl-2-picrylhydrazul (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) scavenging free radical activity assays; metal chelating power test; and ferric reducing/antioxidant power (FRAP) examination. The result revealed that seventeen compounds had potential anti-oxidative capabilities. In addition, the anti-tyrosinase effect was determined by calculating the hydroxylation of L-tyrosine to L-dopa and the oxidization of L-dopa to dopaquinone, according to in vitro mushroom tyrosinase evaluation platform. Furthermore, based on assays on B16F10 cell line, our data suggest that five compounds isolated from L. tulipifera would be able to inhibit tyrosinase activity and reduce the melanin content in animal cells. Therefore, some of the examined compounds could be potentially used in the cosmetic skin whitening business, therapeutic applications or the food industry.

4-(Phenylsulfanyl)butan-2-One Suppresses Melanin Synthesis and Melanosome Maturation In Vitro and In Vivo

“…The most important pigment determining human skin color is melanin. Melanogenesis suppressors are useful as therapeutics for hyper-pigmentation and have application in the cosmetic industry [ 7 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. The purpose of this study was to identify novel natural and potent inhibitors of melanin production.…”

Reversing UVB‐induced photoaging with Hibiscus sabdariffa calyx aqueous extract

“…Skin aging can briefly be divided into three categories: ROS, decreasing ability of cells to replicate, and degradation of ECM. Reactive oxygen species are usually produced as side products of aerobic metabolism in the mitochondria, causing intrinsic aging . Cellular senescence is the decrease of cell replication ability with time, and often occurs in aged skin.…”

“…Reactive oxygen species are usually produced as side products of aerobic metabolism in the mitochondria, causing intrinsic aging. 6 Cellular senescence is the decrease of cell replication ability with time, and often occurs in aged skin. With time, the increased expression of matrix metalloproteinase (MMP), which degrades collagen in ECM, has been shown in senescent fibroblasts.…”

Melanogenesis: Key Role of Bioactive Compounds in the Treatment of Hyperpigmentory Disorders

“…Greyia flanaganii leaf extract [84], ethanolic extracts of Salvia cryptantha and Salvia cyanescens [85], ethanolic extracts of grape seeds and peels [86], stem bark extract of Bauhinia rufescens [87], dried flower extract of Inula britannica [88], stems extract of Liriodendron tulipifera [89], Cotoneaster nummularia extract [90], Cocoa pod extract [91], Salacia reticulate extract [92], resveratrol and oxyresveratrol isolated from citrus fruits [93], which have been found to possess strong tyrosinase inhibitory activity as shown in various in vivo and in vitro pigment cell systems.…”