Biofunctionalization of polyetheretherketone implant material by bone-forming peptide-2 immobilization

Tukmachi, Mustafa S.; Abdul-Baqi, Hikmat J.; Hussein, Falah H.

doi:10.33640/2405-609x.3283

Cited by 5 publications

(3 citation statements)

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“…Cholesterol levels 71,1998 assembly, gelation, cross-linking, solvent evaporation, spray drying, compression, and freeze-drying. 73,[77][78][79] The choice of method depends on the desired particle size and drug-release profile. The pectin-chitosan composite is a highly promising material for drug delivery, as it ensures biocompatibility with minimal adverse effects on living tissues.…”

Section: Pectin With High Methoxylationmentioning

confidence: 99%

Exploring the Synergistic Potential of Pectin-Chitosan Composites for Advanced Drug Delivery and Biomedical Implant Applications: A Comprehensive Review and Future Perspectives

Alsharbaty,

Naji,

Ali

2024

F1000Res

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The polysaccharides pectin and chitosan are derived from the fruit peels and exoskeletons of crustaceans and insects, respectively. Their biocompatibility and renewability make them suitable for use in food products. The size of the swelling and degradation of these cells can be controlled using different combinations. Pectin and chitosan are useful as medication delivery systems, where they can be integrated to control the dosages and residence times of pharmaceuticals. They have a wide range of applications such as wound dressings, body fat reducers, tissue engineering agents, and drug delivery agents. Addressing teeth loss with the use of dental implants is a critical element of dental care. In most cases, healing is time-consuming and painful. As a result of adding new materials to the implant surface, the healing process would accelerate, and medications would be delivered to the implant site with greater efficiency.

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Section: Pectin With High Methoxylationmentioning

confidence: 99%

Exploring the Synergistic Potential of Pectin-Chitosan Composites for Advanced Drug Delivery and Biomedical Implant Applications: A Comprehensive Review and Future Perspectives

Alsharbaty,

Naji,

Ali

2024

F1000Res

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“…Thirty disc-shaped samples of medical-grade PEEK were provided by Energetic Industry Co., Ltd., which is located in Beiliu, China. By cutting continuous extruded PEEK rods, disc-shaped samples with a 10 mm diameter and a 2 mm thickness [16] were created. For the in vitro surface characterization of sulfonated PEEK, these discs served as the test subject.…”

Section: Preparing the Samplesmentioning

confidence: 99%

Sulfonation Treatment of Polyether-Ether-Ketone for Dental Implant Uses

Hamid,

Safi,

Hussein

2024

Applied Sciences

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There has been a recent uptake in the use of polyether-ether-ketone (PEEK), which is an organic thermoplastic polymer, in the manufacturing of various medical devices, implants, and equipment. Finding the best time and procedure for PEEK after sulfonation is the goal of this research. A total of 30 PEEK discs were sulfonated in this study by immersing them in concentrated (H2SO4) sulfuric acid for various durations and subsequently treated using various post-treatment techniques. Five experiments were carried out, aimed studying the effect of immersion time (5 s–2 min). The methods used as post-treatment were hydrothermal treatment, immersion in NaOH, and washing with acetone. The sulfonation time was measured, and the post-treatment techniques, surface characterizations, were conducted using scanning electron microscopy (SEM) (Electron Optics Instruments, LLC., West Orange, NJ, USA), atomic force microscopy (AFM) (AFM, Vía Burton, CA, USA), and hydrophilic properties. The results were confirmed by attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR). The findings of this study demonstrate that sulfonating PEEK caused a structure with a porous network to form in every sample. As the sulfonation time increased, the porous structure became more noticeable and the concentration increased. As a consequence, the roughness of the surface increased notably, and the modified PEEK surface’s wettability improved noticeably. Hydrothermal treatment was determined to be the most successful way for eliminating the leftover sulfuric acid, and sulfonation for 2 min was determined to be ideal. By understanding the best post-treatment procedures and ideal sulfonation duration, a theoretical foundation for the production of sulfonated PEEK for orthopedic uses may be laid.

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“…Successful implant surface treatment has promoted bone growth and attachment, a process called osseointegration [11]. The response of osteoblasts (bone-forming cells) to the implanted material depends on the material's surface properties regarding topography and surface chemistry [2,12].…”

Section: Introductionmentioning

confidence: 99%

Studying and Characterization of Coating of Zein–CaSiO3 Composite on Polyetheretherketone Implant Material

Abdulrazzaq,

Ismael Hamad

2024

International Journal of Dentistry

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Material-coated implants are placed in the bone and play an essential role in bone regeneration and rapid healing around implants. Polymeric matrix reinforced with ceramic materials is a promising composite material for coating implants. This study aims to determine the effect of mixing various concentrations of zein with CaSiO3 on polyetheretherketone (PEEK) as implant material. The coating was performed using the electrospray method. PEEK disks were used as a control group. The coated disks with different concentrations of zein–CaSiO3 (Group 1: 10% wt, 90% wt), (Group 2: 20% wt, 80% wt), and (Group 3%: 30% wt, 70% wt) were the experimental group. Each group was characterized by atomic force microscopy, field emission scanning electron microscope, Fourier-transform infrared spectroscopy, water contact angle, and adhesion strength. The lowest water contact angle was obtained for Group 1: 10% wt and 90% wt were (26.64° and 27.13°, respectively), and increasing amounts of zein in comparison to quantities of CaSiO3 resulted in increased adhesion strength of the composite material to the substrate. The current study suggested that the higher amount of zein compared to the amount of CaSiO3 mixture coating is achieved by electrospraying, a favorable candidate for coating implants compared to uncoated and coated disks with low concentrations of zein compared to concentrations of CaSiO3.

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Biofunctionalization of polyetheretherketone implant material by bone-forming peptide-2 immobilization

Cited by 5 publications

References 0 publications

Exploring the Synergistic Potential of Pectin-Chitosan Composites for Advanced Drug Delivery and Biomedical Implant Applications: A Comprehensive Review and Future Perspectives

Exploring the Synergistic Potential of Pectin-Chitosan Composites for Advanced Drug Delivery and Biomedical Implant Applications: A Comprehensive Review and Future Perspectives

Sulfonation Treatment of Polyether-Ether-Ketone for Dental Implant Uses

Studying and Characterization of Coating of Zein–CaSiO3 Composite on Polyetheretherketone Implant Material

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