Biofunctionalization of the implant surface with different concentrations of a synthetic peptide (P‐15)

Abstract

Objective This study aimed at identifying the ideal concentration of a biofunctional surface coating of dental implants with a synthetic peptide (P‐15). In a previous study, P‐15 was shown to enhance osseointegration parameters. Material and methods Implants (modified ANKYLOS® A8; FRIADENT Plus® surface) with five different concentrations (0–400 μg/ml) of a P‐15 coating as well as uncoated controls were inserted in the frontal bone of 45 adult domestic pigs. The histomorphometric and microradiographic findings for the coated implants were compared to those for the uncoated ones after 7, 14, and 30 days. Results No significant differences were observed comparing the peri‐implant bone density between the coated and uncoated implants The bone‐to‐implant contact, as the primary histological parameter for osseointegration, showed high rates for all surfaces investigated (between 73.3 ± 17.9% for the control and 81.9 ± 15.2% for P15 20 μg/ml after 30 days). Conclusions No significant benefit on osseointegration of a biofunctional P‐15 coating of dental implants could be displayed in the present study.

Progression of Osteogenic Cell Cultures Grown on Microtopographic Titanium Coated With Calcium Phosphate and Functionalized With a Type I Collagen‐Derived Peptide

“…Because no CaP‐coated Ti with no peptide was used in that study, the positive effects on osseointegration would not necessarily be attributable to the P‐15 functionalization. Importantly, a more recent study from the same group, 50 with proper controls, revealed no significant impact of P‐15 on interfacial bone formation at concentrations ranging from 20 to 400 μg/mL.…”

Increased osseointegration effect of bone morphogenetic protein 2 on dental implants: An in vivo study

“…Recently, additional modifications to bioactivate the implant surface using peptide sequences, growth factors, or osteoinductive proteins have been of great interest. A well‐known osteoinductive factor, the bone morphogenic protein 2 (BMP‐2), has been reported to further stimulate local bone formation and osseointegration .…”

Implantatoberflächen und ihr Einfluss auf das periimplantäre Hartgewebe

“…Beide fördern die Zelladhäsion [77,78], die Daten zum Einfluss auf die Knochenheilung sind allerdings auch hier widersprüchlich. In manchen Studien zeigte P15 einen positiven Effekt auf die Osseointegration [79], der sich in anderen Studien nicht bestätigte [80].…”