Biofunctionalized fibrin gel co-embedded with BMSCs and VEGF for accelerating skin injury repair

Tan, Jianying; Li, Li; Wang, Huanran; Wei, Lai; Gao, Xiali; Zeng, Zheng; Liu, Sainan; Fan, Yunge; Liu, Tao; Chen, Junying

doi:10.1016/j.msec.2020.111749

Cited by 31 publications

(17 citation statements)

References 48 publications

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“…Swelling ratio is an important index to evaluate the hydrophilicity of wound dressing agents, because higher swelling rate is beneficial to cell adhesion and osmotic growth ( Amirian et al, 2021 ; Tan et al, 2021 ; Wang S. et al, 2021 ). First, weigh the dry weight (D) of three samples (100 mg) TADM and FBADM scaffold, soak them with pure water, remove the surface water of the scaffold with filter paper, weigh the scaffold wet weight (W), and calculate the swelling rate of the acellular scaffold with the following formula:

…”

Section: Methodsmentioning

confidence: 99%

Application of Tilapia Skin Acellular Dermal Matrix to Induce Acute Skin Wound Repair in Rats

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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Extracellular matrix (ECM) material with good biological activity is essential to simulate cell growth microenvironment, induce cell infiltration and angiogenesis, and promote the repair of large area acute skin wound. In this study, tilapia skin acellular dermal matrix (TADM) was prepared to simulate ECM microenvironment, which can promote substantial area acute wound healing in rats. The main component of TADM is type I collagen, which has good physical and chemical properties, biological activity and cell adhesion. TADM is a form of biomaterial with low immunogenicity, low risk of prion infection and lower economic cost than other related materials such as mammalian collagen biomaterials. Our results show that TADM can guide cell infiltration, angiogenesis, regulate the expression and secretion of inflammatory and skin repair correlated factors to promote tissue healing.

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…”

Section: Methodsmentioning

confidence: 99%

Application of Tilapia Skin Acellular Dermal Matrix to Induce Acute Skin Wound Repair in Rats

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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“…99 The individual components of fibrinogen and thrombin provide significant flexibility to the culture system, since the mechanical properties such as thickness and pore size can be easily modulated by changing the ratio of fibrinogen and thrombin in the hydrogel. 100 It is of concern that the fibrin used in the culture system is typically sourced from human plasma. 29 The single source makes it hard to broaden applications, especially for the commercial production of MSC culture, although the fibrin matrix makes it suitable for the hemostatic bandage and wound healing.…”

Section: Methodsmentioning

confidence: 99%

Recent advances in 3D hydrogel culture systems for mesenchymal stem cell-based therapy and cell behavior regulation

Xia

Cai

2022

J. Mater. Chem. B

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“…VEGF acts as critical molecular targets to increase vascular permeability and promote vascularization [101]. After VEGF and BMSCs were co-embedded in a 3D gel prepared from fibrinogen and thrombin, the defective area exhibited intact dermis and epidermis after 3 days in the SD rat model [102]. PDGF acts primarily as a chemo-attractant for the neutrophils and fibroblasts [103].…”

Section: Growth Factors-loaded Scaffoldsmentioning

confidence: 99%

Advances in Skin Wound and Scar Repair by Polymer Scaffolds

et al. 2021

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Scars, as the result of abnormal wound-healing response after skin injury, may lead to loss of aesthetics and physical dysfunction. Current clinical strategies, such as surgical excision, laser treatment, and drug application, provide late remedies for scarring, yet it is difficult to eliminate scars. In this review, the functions, roles of multiple polymer scaffolds in wound healing and scar inhibition are explored. Polysaccharide and protein scaffolds, an analog of extracellular matrix, act as templates for cell adhesion and migration, differentiation to facilitate wound reconstruction and limit scarring. Stem cell-seeded scaffolds and growth factors-loaded scaffolds offer significant bioactive substances to improve the wound healing process. Special emphasis is placed on scaffolds that continuously release oxygen, which greatly accelerates the vascularization process and ensures graft survival, providing convincing theoretical support and great promise for scarless healing.

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Biofunctionalized fibrin gel co-embedded with BMSCs and VEGF for accelerating skin injury repair

Cited by 31 publications

References 48 publications

Application of Tilapia Skin Acellular Dermal Matrix to Induce Acute Skin Wound Repair in Rats

Application of Tilapia Skin Acellular Dermal Matrix to Induce Acute Skin Wound Repair in Rats

Recent advances in 3D hydrogel culture systems for mesenchymal stem cell-based therapy and cell behavior regulation

Advances in Skin Wound and Scar Repair by Polymer Scaffolds

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