Biofunctionalized Quantum Dots for Live Monitoring of Stem Cells: Applications in Regenerative Medicine

Mel, Achala de; Oh, Jung-Taek; Ramesh, Bala; Seifalian, Alexander M.

doi:10.2217/rme.12.21

Cited by 14 publications

(11 citation statements)

References 65 publications

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“…The reports on the application of QDs for regenerative medicine as another nanomedicine domain are currently limited to a couple of dozens and are mostly related to testing of the innovative tissue engineering systems performance [104,105] or stem cells tracking using QDs as fluorescent labels [106,107] and therefore are not discussed in detail in the current review.…”

Section: Quantum Dots For Diagnostics and Therapymentioning

confidence: 99%

Quantum dots in nanomedicine: recent trends, advances and unresolved issues

Volkov

2015

Biochemical and Biophysical Research Communications

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a b s t r a c tThe review addresses the current state of progress in the use of ultra-small nanoparticles from the category of quantum dots (QDs), which presently embraces a widening range of nanomaterials of different nature, including "classical" semiconductor groups III-V and II-VI nanocrystals, along with more recently emerged carbon, silicon, gold and other types of nanoparticles falling into this class of nanomaterials due to their similar physical characteristics such as small size and associated quantum confinement effects. A diverse range of QDs applications in nanomedicine has been extensively summarised previously in numerous publications. Therefore, this review is not intended to provide an all-embracing survey of the well documented QDs uses, but is rather focused on the most recent emerging developments, concepts and outstanding unresolved problematic and sometimes controversial issues. Over 125 publications are overviewed and discussed here in the context of major nanomedicine domains, i.e. medical imaging, diagnostics, therapeutic applications and combination of them in multifunctional theranostic systems.© 2015 Elsevier Inc. All rights reserved. Quantum dots in nanomedicine: recent trendsWithin a steadily increasing database of diverse nanomaterials reported as suitable for applications in nanomedicine [1e10], quantum dots (QDs) deservedly occupy a special niche as nanoparticles with a unique track record full of high expectations, dramatic pitfalls and often controversial experimental evidence. From the early optimistic aspirations of them as breakthrough tools for multipurpose in vitro and in vivo applications [11e17], they have been subject to a period of partial relinquishment following the sombre realisation that in the original unmodified state QDs did not stand a chance to deserve a unanimous approval as imaging or drug delivery vehicles in humans, due to their intrinsic toxicity and lack of biodegradability perspective. The disappointingly low yield of exploitable outputs following the initial rounds of heavy investments in the field has also contributed to the overall decline in research productivity metrics. The analysis of the recent ten years' trends in publications number in this area related to the QDs medical applications in vivo in general (Fig. 1 A), as well as for imaging and diagnostics purposes (Fig. 1 B, C) according to Thomson Reuters Web of Science™ database clearly reflects such "cooling down" period after 2010 resulting in a significant reduction in the initially steady exponential growth of publication rates. This trend has been partially or completely reversed by 2014 and it is intriguing whether we will see it sustained in 2015 and beyond.Such returning enthusiasm has been reinvigorated by a number of objective tendencies in the related technological developments, including the arrival of innovative nanotechnology-enabled tools for diagnostic and ex vivo imaging applications [18,19], the arrival of new types of QDs of alternative nature offering the opportunities of r...

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Section: Quantum Dots For Diagnostics and Therapymentioning

confidence: 99%

Quantum dots in nanomedicine: recent trends, advances and unresolved issues

Volkov

2015

Biochemical and Biophysical Research Communications

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“…In order to adhere antibody fragments to biomimetic materials devoid of functional groups, polymers such as poly-L-lysine can be used to first coat the synthetic material, or PLGA scaffolds can be utilized to allow simple surface immobilization of proteins (reviewed in [208]). The potential of polymer-antibody conjugates in this emerging field of biomedicine is enormous and only beginning to be realized, as exemplified by a recent demonstration of the use of antibody-functionalizedquantum dots(QD) to monitor the integration of epithelial progenitor cells onto polymer-based tissue engineering implants grown on scaffolds [209].…”

Section: Page 27 Of 54mentioning

confidence: 99%

Polymer-antibody fragment conjugates for biomedical applications

Srivastava

O'Connor

Pandit

et al. 2014

Progress in Polymer Science

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“…Ultrasmall paramagnetic iron oxide nanoparticles (Harrington et al, 2011) or other imaging contrast agents encapsulated in nanocarriers can be used to improve nondestructive imaging modalities (i.e., theragnostics). Specifically, iron oxide is useful for magnetic resonance imaging (Xu et al, 2012a), iodine, or gold nanoparticles for computed tomography (Kao et al, 2003), and as noted above, quantum dots (de Mel et al, 2012) are also being used for imaging modalities in regenerative medicine.…”

Section: A Particulate Systems For Cell and Drug Deliverymentioning

confidence: 99%