2001
DOI: 10.1016/s0166-6851(01)00261-4
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Biogenesis and function of peroxisomes and glycosomes

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Cited by 96 publications
(70 citation statements)
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“…2). Thus, the enzymes involved in the synthesis of polyamines, like those for purine and pyrimidine nucleotide synthesis (35,(62)(63)(64), are compartmentalized between the glycosome and cytosol in Leishmania. The rationale for the sequestering of ARG from the cytosolic ODC, SPDSYN, and ADOMETDC is not apparent, but the glycosomal milieu is not essential for ARG function in promastigotes because of the ability of cytosolic arg (arg⌬skl) to complement ⌬arg parasites (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…2). Thus, the enzymes involved in the synthesis of polyamines, like those for purine and pyrimidine nucleotide synthesis (35,(62)(63)(64), are compartmentalized between the glycosome and cytosol in Leishmania. The rationale for the sequestering of ARG from the cytosolic ODC, SPDSYN, and ADOMETDC is not apparent, but the glycosomal milieu is not essential for ARG function in promastigotes because of the ability of cytosolic arg (arg⌬skl) to complement ⌬arg parasites (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…However, in trypanosomatids this pathway, along with pathways involved in ␤-oxidation of fatty acids, ether lipid biosynthesis, and purine salvage, is compartmentalized to the glycosome (32-35, 42, 43). Glycosomes are single membranebound organelles related to peroxisomes (35). Peroxisomes have been shown to be a major source of reactive oxygen species (44,45), and most organisms have evolved a peroxisomal oxidative defense system that includes copper/zinc superoxide dismutase, glutathione peroxidase, and catalase (39, 46 -48).…”
Section: Discussionmentioning
confidence: 99%
“…Leishmania express four enzymes that are capable of converting host or extracellular purines into nucleotides: 1) hypoxanthine-guanine phosphoribosyltransferase (HGPRT) xanthine phosphoribosyltransferase (XPRT); 3) adenine phosphoribosyltransferase (APRT); 4) and adenosine kinase (2,5,9,10). HGPRT and XPRT are confined within the glycosome (11,12), a membrane-bound microbody organelle that is found exclusively among trypanosomatid parasites (13)(14)(15), whereas APRT has been definitively localized to the cytosol (12). Genetic studies in L. donovani reveal that none of the four enzymes by itself is essential for parasite survival because promastigotes deficient in the activity of any one of the four purine salvage enzymes are viable and do not exhibit a fitness deficit (16 -20).…”
mentioning
confidence: 99%